Cover Image

The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities

Multiple myeloma (MM) is a plasma cell malignancy of the bone marrow. Despite therapeutic advances, MM remains incurable, and better risk stratification as well as new therapies are therefore highly needed. The proteome of MM has not been systematically assessed before and holds the potential to unc...

Full description

Saved in:
Bibliographic Details
Main Authors: Ramberger, Evelyn (Author) , Sapozhnikova, Valeriia (Author) , Ng, Yuen Lam Dora (Author) , Dolnik, Anna (Author) , Ziehm, Matthias (Author) , Popp, Oliver (Author) , Sträng, Eric (Author) , Kull, Miriam (Author) , Grünschläger, Florian (Author) , Krüger, Josefine (Author) , Benary, Manuela (Author) , Müller, Sina (Author) , Gao, Xiang (Author) , Murgai, Arunima (Author) , Haji, Mohamed (Author) , Schmidt, Annika (Author) , Lutz, Raphael (Author) , Nogai, Axel (Author) , Braune, Jan (Author) , Laue, Dominik (Author) , Langer, Christian (Author) , Khandanpour, Cyrus (Author) , Bassermann, Florian (Author) , Döhner, Hartmut (Author) , Engelhardt, Monika (Author) , Straka, Christian (Author) , Hundemer, Michael (Author) , Beule, Dieter (Author) , Haas, Simon (Author) , Keller, Ulrich (Author) , Einsele, Hermann (Author) , Bullinger, Lars (Author) , Knop, Stefan (Author) , Mertins, Philipp (Author) , Krönke, Jan (Author)
Format: Article (Journal)
Language:English
Published: August 2024
In: Nature cancer
Year: 2024, Volume: 5, Issue: 8, Pages: 1267-1284
ISSN:2662-1347
DOI:10.1038/s43018-024-00784-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s43018-024-00784-3
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s43018-024-00784-3
Get full text
Author Notes:Evelyn Ramberger, Valeriia Sapozhnikova, Yuen Lam Dora Ng, Anna Dolnik, Matthias Ziehm, Oliver Popp, Eric Sträng, Miriam Kull, Florian Grünschläger, Josefine Krüger, Manuela Benary, Sina Müller, Xiang Gao, Arunima Murgai, Mohamed Haji, Annika Schmidt, Raphael Lutz, Axel Nogai, Jan Braune, Dominik Laue, Christian Langer, Cyrus Khandanpour, Florian Bassermann, Hartmut Döhner, Monika Engelhardt, Christian Straka, Michael Hundemer, Dieter Beule, Simon Haas, Ulrich Keller, Hermann Einsele, Lars Bullinger, Stefan Knop, Philipp Mertins & Jan Krönke

MARC

LEADER 00000caa a2200000 c 4500
001 193774857X
003 DE-627
005 20251204123143.0
007 cr uuu---uuuuu
008 251006s2024 xx |||||o 00| ||eng c
024 7 |a 10.1038/s43018-024-00784-3  |2 doi 
035 |a (DE-627)193774857X 
035 |a (DE-599)KXP193774857X 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Ramberger, Evelyn  |e VerfasserIn  |0 (DE-588)1218978228  |0 (DE-627)1734609109  |4 aut 
245 1 4 |a The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities  |c Evelyn Ramberger, Valeriia Sapozhnikova, Yuen Lam Dora Ng, Anna Dolnik, Matthias Ziehm, Oliver Popp, Eric Sträng, Miriam Kull, Florian Grünschläger, Josefine Krüger, Manuela Benary, Sina Müller, Xiang Gao, Arunima Murgai, Mohamed Haji, Annika Schmidt, Raphael Lutz, Axel Nogai, Jan Braune, Dominik Laue, Christian Langer, Cyrus Khandanpour, Florian Bassermann, Hartmut Döhner, Monika Engelhardt, Christian Straka, Michael Hundemer, Dieter Beule, Simon Haas, Ulrich Keller, Hermann Einsele, Lars Bullinger, Stefan Knop, Philipp Mertins & Jan Krönke 
264 1 |c August 2024 
300 |b Illustrationen 
300 |a 18 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Online veröffentlicht: 28. Juni 2024 
500 |a Gesehen am 06.10.2025 
520 |a Multiple myeloma (MM) is a plasma cell malignancy of the bone marrow. Despite therapeutic advances, MM remains incurable, and better risk stratification as well as new therapies are therefore highly needed. The proteome of MM has not been systematically assessed before and holds the potential to uncover insight into disease biology and improved prognostication in addition to genetic and transcriptomic studies. Here we provide a comprehensive multiomics analysis including deep tandem mass tag-based quantitative global (phospho)proteomics, RNA sequencing, and nanopore DNA sequencing of 138 primary patient-derived plasma cell malignancies encompassing treatment-naive MM, plasma cell leukemia and the premalignancy monoclonal gammopathy of undetermined significance, as well as healthy controls. We found that the (phospho)proteome of malignant plasma cells are highly deregulated as compared with healthy plasma cells and is both defined by chromosomal alterations as well as posttranscriptional regulation. A prognostic protein signature was identified that is associated with aggressive disease independent of established risk factors in MM. Integration with functional genetics and single-cell RNA sequencing revealed general and genetic subtype-specific deregulated proteins and pathways in plasma cell malignancies that include potential targets for (immuno)therapies. Our study demonstrates the potential of proteogenomics in cancer and provides an easily accessible resource for investigating protein regulation and new therapeutic approaches in MM. 
650 4 |a Cancer 
650 4 |a Cancer genomics 
650 4 |a Next-generation sequencing 
650 4 |a Proteomics 
700 1 |a Sapozhnikova, Valeriia  |e VerfasserIn  |4 aut 
700 1 |a Ng, Yuen Lam Dora  |e VerfasserIn  |4 aut 
700 1 |a Dolnik, Anna  |e VerfasserIn  |4 aut 
700 1 |a Ziehm, Matthias  |e VerfasserIn  |4 aut 
700 1 |a Popp, Oliver  |e VerfasserIn  |4 aut 
700 1 |a Sträng, Eric  |e VerfasserIn  |4 aut 
700 1 |a Kull, Miriam  |e VerfasserIn  |4 aut 
700 1 |a Grünschläger, Florian  |d 1991-  |e VerfasserIn  |0 (DE-588)1337719617  |0 (DE-627)1897553382  |4 aut 
700 1 |a Krüger, Josefine  |e VerfasserIn  |4 aut 
700 1 |a Benary, Manuela  |e VerfasserIn  |4 aut 
700 1 |a Müller, Sina  |e VerfasserIn  |4 aut 
700 1 |a Gao, Xiang  |e VerfasserIn  |4 aut 
700 1 |a Murgai, Arunima  |e VerfasserIn  |4 aut 
700 1 |a Haji, Mohamed  |e VerfasserIn  |4 aut 
700 1 |a Schmidt, Annika  |e VerfasserIn  |4 aut 
700 1 |a Lutz, Raphael  |d 1986-  |e VerfasserIn  |0 (DE-588)1131562461  |0 (DE-627)886137020  |0 (DE-576)488288584  |4 aut 
700 1 |a Nogai, Axel  |e VerfasserIn  |4 aut 
700 1 |8 1\p  |a Braune, Jan  |d 1994-  |e VerfasserIn  |0 (DE-588)1230170766  |0 (DE-627)175263246X  |4 aut 
700 1 |a Laue, Dominik  |e VerfasserIn  |4 aut 
700 1 |a Langer, Christian  |e VerfasserIn  |4 aut 
700 1 |a Khandanpour, Cyrus  |d 1977-  |e VerfasserIn  |0 (DE-588)130838004  |0 (DE-627)506356671  |0 (DE-576)298368315  |4 aut 
700 1 |8 2\p  |a Bassermann, Florian  |d 1973-  |e VerfasserIn  |0 (DE-588)123743109  |0 (DE-627)082740585  |0 (DE-576)293855595  |4 aut 
700 1 |a Döhner, Hartmut  |e VerfasserIn  |4 aut 
700 1 |a Engelhardt, Monika  |e VerfasserIn  |4 aut 
700 1 |a Straka, Christian  |e VerfasserIn  |4 aut 
700 1 |a Hundemer, Michael  |d 1972-  |e VerfasserIn  |0 (DE-588)128390549  |0 (DE-627)372634001  |0 (DE-576)297117998  |4 aut 
700 1 |a Beule, Dieter  |e VerfasserIn  |4 aut 
700 1 |a Haas, Simon  |e VerfasserIn  |0 (DE-588)1113199180  |0 (DE-627)867112735  |0 (DE-576)37798146X  |4 aut 
700 1 |a Keller, Ulrich  |e VerfasserIn  |4 aut 
700 1 |a Einsele, Hermann  |e VerfasserIn  |4 aut 
700 1 |a Bullinger, Lars  |e VerfasserIn  |4 aut 
700 1 |a Knop, Stefan  |e VerfasserIn  |4 aut 
700 1 |a Mertins, Philipp  |e VerfasserIn  |4 aut 
700 1 |a Krönke, Jan  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Nature cancer  |d London : Nature Research, 2020  |g 5(2024), 8 vom: Aug., Seite 1267-1284  |h Online-Ressource  |w (DE-627)1687330697  |w (DE-600)3005299-3  |x 2662-1347  |7 nnas  |a The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities 
773 1 8 |g volume:5  |g year:2024  |g number:8  |g month:08  |g pages:1267-1284  |g extent:18  |a The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities 
856 4 0 |u https://doi.org/10.1038/s43018-024-00784-3  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.nature.com/articles/s43018-024-00784-3  |x Verlag  |z kostenfrei  |3 Volltext 
883 |8 1\p  |a cgwrk  |q DE-101  |u https://d-nb.info/provenance/plan#cgwrk 
883 |8 2\p  |a cgwrk  |q DE-101  |u https://d-nb.info/provenance/plan#cgwrk 
951 |a AR 
992 |a 20251006 
993 |a Article 
994 |a 2024 
998 |g 128390549  |a Hundemer, Michael  |m 128390549:Hundemer, Michael  |d 910000  |d 910100  |d 50000  |e 910000PH128390549  |e 910100PH128390549  |e 50000PH128390549  |k 0/910000/  |k 1/910000/910100/  |k 0/50000/  |p 27 
998 |g 1131562461  |a Lutz, Raphael  |m 1131562461:Lutz, Raphael  |d 910000  |d 910100  |e 910000PL1131562461  |e 910100PL1131562461  |k 0/910000/  |k 1/910000/910100/  |p 17 
998 |g 1337719617  |a Grünschläger, Florian  |m 1337719617:Grünschläger, Florian  |d 140000  |e 140000PG1337719617  |k 0/140000/  |p 9 
999 |a KXP-PPN193774857X  |e 4781193803 
BIB |a Y 
SER |a journal 
JSO |a {"title":[{"title":"The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities","title_sort":"proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities"}],"person":[{"display":"Ramberger, Evelyn","roleDisplay":"VerfasserIn","given":"Evelyn","family":"Ramberger","role":"aut"},{"family":"Sapozhnikova","roleDisplay":"VerfasserIn","display":"Sapozhnikova, Valeriia","given":"Valeriia","role":"aut"},{"family":"Ng","given":"Yuen Lam Dora","roleDisplay":"VerfasserIn","display":"Ng, Yuen Lam Dora","role":"aut"},{"role":"aut","family":"Dolnik","roleDisplay":"VerfasserIn","display":"Dolnik, Anna","given":"Anna"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Ziehm, Matthias","given":"Matthias","family":"Ziehm"},{"role":"aut","family":"Popp","roleDisplay":"VerfasserIn","display":"Popp, Oliver","given":"Oliver"},{"family":"Sträng","roleDisplay":"VerfasserIn","display":"Sträng, Eric","given":"Eric","role":"aut"},{"role":"aut","family":"Kull","given":"Miriam","roleDisplay":"VerfasserIn","display":"Kull, Miriam"},{"family":"Grünschläger","roleDisplay":"VerfasserIn","display":"Grünschläger, Florian","given":"Florian","role":"aut"},{"family":"Krüger","roleDisplay":"VerfasserIn","display":"Krüger, Josefine","given":"Josefine","role":"aut"},{"role":"aut","family":"Benary","roleDisplay":"VerfasserIn","display":"Benary, Manuela","given":"Manuela"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Müller, Sina","given":"Sina","family":"Müller"},{"role":"aut","display":"Gao, Xiang","roleDisplay":"VerfasserIn","given":"Xiang","family":"Gao"},{"given":"Arunima","roleDisplay":"VerfasserIn","display":"Murgai, Arunima","family":"Murgai","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Haji, Mohamed","given":"Mohamed","family":"Haji","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Annika","display":"Schmidt, Annika","family":"Schmidt"},{"role":"aut","display":"Lutz, Raphael","roleDisplay":"VerfasserIn","given":"Raphael","family":"Lutz"},{"display":"Nogai, Axel","roleDisplay":"VerfasserIn","given":"Axel","family":"Nogai","role":"aut"},{"family":"Braune","display":"Braune, Jan","roleDisplay":"VerfasserIn","given":"Jan","role":"aut"},{"role":"aut","family":"Laue","given":"Dominik","roleDisplay":"VerfasserIn","display":"Laue, Dominik"},{"role":"aut","family":"Langer","given":"Christian","roleDisplay":"VerfasserIn","display":"Langer, Christian"},{"family":"Khandanpour","roleDisplay":"VerfasserIn","given":"Cyrus","display":"Khandanpour, Cyrus","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Florian","display":"Bassermann, Florian","family":"Bassermann"},{"family":"Döhner","display":"Döhner, Hartmut","roleDisplay":"VerfasserIn","given":"Hartmut","role":"aut"},{"display":"Engelhardt, Monika","roleDisplay":"VerfasserIn","given":"Monika","family":"Engelhardt","role":"aut"},{"role":"aut","family":"Straka","roleDisplay":"VerfasserIn","display":"Straka, Christian","given":"Christian"},{"role":"aut","family":"Hundemer","display":"Hundemer, Michael","roleDisplay":"VerfasserIn","given":"Michael"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Beule, Dieter","given":"Dieter","family":"Beule"},{"role":"aut","given":"Simon","roleDisplay":"VerfasserIn","display":"Haas, Simon","family":"Haas"},{"roleDisplay":"VerfasserIn","given":"Ulrich","display":"Keller, Ulrich","family":"Keller","role":"aut"},{"family":"Einsele","given":"Hermann","roleDisplay":"VerfasserIn","display":"Einsele, Hermann","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Bullinger, Lars","given":"Lars","family":"Bullinger","role":"aut"},{"role":"aut","display":"Knop, Stefan","roleDisplay":"VerfasserIn","given":"Stefan","family":"Knop"},{"display":"Mertins, Philipp","roleDisplay":"VerfasserIn","given":"Philipp","family":"Mertins","role":"aut"},{"role":"aut","display":"Krönke, Jan","roleDisplay":"VerfasserIn","given":"Jan","family":"Krönke"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Evelyn Ramberger, Valeriia Sapozhnikova, Yuen Lam Dora Ng, Anna Dolnik, Matthias Ziehm, Oliver Popp, Eric Sträng, Miriam Kull, Florian Grünschläger, Josefine Krüger, Manuela Benary, Sina Müller, Xiang Gao, Arunima Murgai, Mohamed Haji, Annika Schmidt, Raphael Lutz, Axel Nogai, Jan Braune, Dominik Laue, Christian Langer, Cyrus Khandanpour, Florian Bassermann, Hartmut Döhner, Monika Engelhardt, Christian Straka, Michael Hundemer, Dieter Beule, Simon Haas, Ulrich Keller, Hermann Einsele, Lars Bullinger, Stefan Knop, Philipp Mertins & Jan Krönke"]},"recId":"193774857X","id":{"doi":["10.1038/s43018-024-00784-3"],"eki":["193774857X"]},"language":["eng"],"note":["Online veröffentlicht: 28. Juni 2024","Gesehen am 06.10.2025"],"physDesc":[{"extent":"18 S.","noteIll":"Illustrationen"}],"relHost":[{"title":[{"title_sort":"Nature cancer","title":"Nature cancer"}],"disp":"The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunitiesNature cancer","language":["eng"],"note":["Gesehen am 14.01.20"],"physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"5","text":"5(2024), 8 vom: Aug., Seite 1267-1284","extent":"18","year":"2024","pages":"1267-1284","issue":"8"},"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["Volume 1, Issue 1, (January 2020)-"],"origin":[{"publisherPlace":"London","dateIssuedDisp":"2020-","publisher":"Nature Research","dateIssuedKey":"2020"}],"recId":"1687330697","id":{"eki":["1687330697"],"zdb":["3005299-3"],"issn":["2662-1347"]}}],"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"August 2024"}]} 
SRT |a RAMBERGEREPROTEOGENO2024 

Similar Items