Risk-factors and multimorbidity in oral anticoagulant-related intracerebral haemorrhage: a comparison of patients in pivotal trials and real life
We hypothesised that morbidity burden was higher in real-life patients with oral anticoagulant-related intracerebral haemorrhage (OAC-ICH) than direct oral anticoagulant (DOAC) trial-life patients (pivotal trial participants) and explored if pre-stroke morbidity was comparable (i) in real-life patie...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 2025
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| In: |
Age & ageing
Year: 2025, Jahrgang: 54, Heft: 4, Pages: 1-8 |
| ISSN: | 1468-2834 |
| DOI: | 10.1093/ageing/afaf091 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/ageing/afaf091
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| Verfasserangaben: | Josefine Grundtvig, David Gaist, Louisa Christensen, Christian Ovesen, Inger Havsteen, Helle K Iversen, Thomas Christensen, Alexander Lilja-Cyron, Christina Kruuse, Karen Ægidius, Sverre Rosenbaum, Per Meden, Jacob Marstrand, Thorsten Steiner, Hanne Christensen |
MARC
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| 100 | 1 | |a Grundtvig, Josefine |e VerfasserIn |0 (DE-588)1258387840 |0 (DE-627)1804363405 |4 aut | |
| 245 | 1 | 0 | |a Risk-factors and multimorbidity in oral anticoagulant-related intracerebral haemorrhage |b a comparison of patients in pivotal trials and real life |c Josefine Grundtvig, David Gaist, Louisa Christensen, Christian Ovesen, Inger Havsteen, Helle K Iversen, Thomas Christensen, Alexander Lilja-Cyron, Christina Kruuse, Karen Ægidius, Sverre Rosenbaum, Per Meden, Jacob Marstrand, Thorsten Steiner, Hanne Christensen |
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| 520 | |a We hypothesised that morbidity burden was higher in real-life patients with oral anticoagulant-related intracerebral haemorrhage (OAC-ICH) than direct oral anticoagulant (DOAC) trial-life patients (pivotal trial participants) and explored if pre-stroke morbidity was comparable (i) in real-life patients on DOAC or vitamin K antagonist (VKA) with ICH, and (ii) in trial-life patients versus real-life patients with OAC-ICH.The COOL-ICH cohort included 401 acute, consecutive patients with OAC-ICH (272 VKA-ICH, 129 DOAC-ICH) from the Capital Region of Denmark. Risk-factors and morbidity in trial-life patients were retrieved from publications.Risk-factors, CHADS2 and Charlson Comorbidity Index were comparable in DOAC vs VKA users in real-life. Pre-stroke modified Rankin Scale (mRS) was higher in DOAC users than in VKA users (median mRS 1 vs 0, P = 0.002). More DOAC users were women (53% vs 39%, P = 0.009). Compared to trial-life patients, age and proportion of women were higher in real-life patients. CHADS2-scores were comparable.In conclusion, burden of risk-factors and comorbidities were similar in real-life patients with DOAC-ICH and VKA-ICH, as well as in real-life patients compared to trial-life patients. However, real-life patients especially those on DOAC, were older and more frequently women than trial-life patients. It is reassuring that burden of comorbidity was similar in real-life and trial-life patients. Nevertheless, this report underlines the importance of recruiting adequate numbers of older people and women to cardio-vascular trials to ensure sufficient safety data to advice prescriptions in these very prevalent sub-groups of patients. | ||
| 700 | 1 | |a Gaist, David |e VerfasserIn |4 aut | |
| 700 | 1 | |a Christensen, Louisa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ovesen, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Havsteen, Inger |e VerfasserIn |4 aut | |
| 700 | 1 | |a Iversen, Helle K |e VerfasserIn |4 aut | |
| 700 | 1 | |a Christensen, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lilja-Cyron, Alexander |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kruuse, Christina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ægidius, Karen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rosenbaum, Sverre |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meden, Per |e VerfasserIn |4 aut | |
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