Buchumschlag

Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer

Clinical trial results have recently demonstrated that inhibiting inflammation by targeting the interleukin-1β pathway can offer a significant reduction in lung cancer incidence and mortality, highlighting a pressing and unmet need to understand the benefits of inflammation-focused lung cancer thera...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Sun, Ryan (VerfasserIn) , Xu, Miao (VerfasserIn) , Li, Xihao (VerfasserIn) , Gaynor, Sheila (VerfasserIn) , Zhou, Hufeng (VerfasserIn) , Li, Zilin (VerfasserIn) , Bossé, Yohan (VerfasserIn) , Lam, Stephen (VerfasserIn) , Tsao, Ming-Sound (VerfasserIn) , Tardon, Adonina (VerfasserIn) , Chen, Chu (VerfasserIn) , Doherty, Jennifer (VerfasserIn) , Goodman, Gary (VerfasserIn) , Bojesen, Stig E. (VerfasserIn) , Landi, Maria T. (VerfasserIn) , Johansson, Mattias (VerfasserIn) , Field, John K. (VerfasserIn) , Bickeböller, Heike (VerfasserIn) , Wichmann, H-Erich (VerfasserIn) , Risch, Angela (VerfasserIn) , Rennert, Gadi (VerfasserIn) , Arnold, Suzanne (VerfasserIn) , Wu, Xifeng (VerfasserIn) , Melander, Olle (VerfasserIn) , Brunnström, Hans (VerfasserIn) , Le Marchand, Loic (VerfasserIn) , Liu, Geoffrey (VerfasserIn) , Andrew, Angeline (VerfasserIn) , Duell, Eric (VerfasserIn) , Kiemeney, Lambertus A. (VerfasserIn) , Shen, Hongbing (VerfasserIn) , Haugen, Aage (VerfasserIn) , Johansson, Mikael (VerfasserIn) , Grankvist, Kjell (VerfasserIn) , Caporaso, Neil (VerfasserIn) , Woll, Penella (VerfasserIn) , Dawn Teare, M. (VerfasserIn) , Scelo, Ghislaine (VerfasserIn) , Hong, Yun-Chul (VerfasserIn) , Yuan, Jian-Min (VerfasserIn) , Lazarus, Philip (VerfasserIn) , Schabath, Matthew B. (VerfasserIn) , Aldrich, Melinda C. (VerfasserIn) , Albanes, Demetrios (VerfasserIn) , Mak, Raymond (VerfasserIn) , Barbie, David (VerfasserIn) , Brennan, Paul (VerfasserIn) , Hung, Rayjean J. (VerfasserIn) , Amos, Christopher I. (VerfasserIn) , Christiani, David C. (VerfasserIn) , Lin, Xihong (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 25 January 2021
In: Genetic epidemiology
Year: 2021, Jahrgang: 45, Heft: 1, Pages: 99-114
ISSN:1098-2272
DOI:10.1002/gepi.22358
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/gepi.22358
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/gepi.22358
Volltext
Verfasserangaben:Ryan Sun, Miao Xu, Xihao Li, Sheila Gaynor, Hufeng Zhou, Zilin Li, Yohan Bossé, Stephen Lam, Ming-Sound Tsao, Adonina Tardon, Chu Chen, Jennifer Doherty, Gary Goodman, Stig E. Bojesen, Maria T. Landi, Mattias Johansson, John K. Field, Heike Bickeböller, H-Erich Wichmann, Angela Risch, Gadi Rennert, Suzanne Arnold, Xifeng Wu, Olle Melander, Hans Brunnström, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Eric Duell, Lambertus A. Kiemeney, Hongbing Shen, Aage Haugen, Mikael Johansson, Kjell Grankvist, Neil Caporaso, Penella Woll, M. Dawn Teare, Ghislaine Scelo, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Demetrios Albanes, Raymond Mak, David Barbie, Paul Brennan, Rayjean J. Hung, Christopher I. Amos, David C. Christiani, Xihong Lin

MARC

LEADER 00000naa a2200000 c 4500
001 1937761304
003 DE-627
005 20251006120547.0
007 cr uuu---uuuuu
008 251006s2021 xx |||||o 00| ||eng c
024 7 |a 10.1002/gepi.22358  |2 doi 
035 |a (DE-627)1937761304 
035 |a (DE-599)KXP1937761304 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Sun, Ryan  |e VerfasserIn  |0 (DE-588)1378277937  |0 (DE-627)1937761061  |4 aut 
245 1 0 |a Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer  |c Ryan Sun, Miao Xu, Xihao Li, Sheila Gaynor, Hufeng Zhou, Zilin Li, Yohan Bossé, Stephen Lam, Ming-Sound Tsao, Adonina Tardon, Chu Chen, Jennifer Doherty, Gary Goodman, Stig E. Bojesen, Maria T. Landi, Mattias Johansson, John K. Field, Heike Bickeböller, H-Erich Wichmann, Angela Risch, Gadi Rennert, Suzanne Arnold, Xifeng Wu, Olle Melander, Hans Brunnström, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Eric Duell, Lambertus A. Kiemeney, Hongbing Shen, Aage Haugen, Mikael Johansson, Kjell Grankvist, Neil Caporaso, Penella Woll, M. Dawn Teare, Ghislaine Scelo, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Demetrios Albanes, Raymond Mak, David Barbie, Paul Brennan, Rayjean J. Hung, Christopher I. Amos, David C. Christiani, Xihong Lin 
264 1 |c 25 January 2021 
300 |a 16 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Zuerst online veröffentlicht: 14. September 2020 
500 |a Gesehen am 06.10.2025 
520 |a Clinical trial results have recently demonstrated that inhibiting inflammation by targeting the interleukin-1β pathway can offer a significant reduction in lung cancer incidence and mortality, highlighting a pressing and unmet need to understand the benefits of inflammation-focused lung cancer therapies at the genetic level. While numerous genome-wide association studies (GWAS) have explored the genetic etiology of lung cancer, there remains a large gap between the type of information that may be gleaned from an association study and the depth of understanding necessary to explain and drive translational findings. Thus, in this study we jointly model and integrate extensive multiomics data sources, utilizing a total of 40 genome-wide functional annotations that augment previously published results from the International Lung Cancer Consortium (ILCCO) GWAS, to prioritize and characterize single nucleotide polymorphisms (SNPs) that increase risk of squamous cell lung cancer through the inflammatory and immune responses. Our work bridges the gap between correlative analysis and translational follow-up research, refining GWAS association measures in an interpretable and systematic manner. In particular, reanalysis of the ILCCO data highlights the impact of highly associated SNPs from nuclear factor-κB signaling pathway genes as well as major histocompatibility complex mediated variation in immune responses. One consequence of prioritizing likely functional SNPs is the pruning of variants that might be selected for follow-up work by over an order of magnitude, from potentially tens of thousands to hundreds. The strategies we introduce provide informative and interpretable approaches for incorporating extensive genome-wide annotation data in analysis of genetic association studies. 
650 4 |a genome-wide annotation 
650 4 |a integrative omics 
650 4 |a lung cancer 
650 4 |a major histocompatibility complex 
700 1 |a Xu, Miao  |e VerfasserIn  |4 aut 
700 1 |a Li, Xihao  |e VerfasserIn  |4 aut 
700 1 |a Gaynor, Sheila  |e VerfasserIn  |4 aut 
700 1 |a Zhou, Hufeng  |e VerfasserIn  |4 aut 
700 1 |a Li, Zilin  |e VerfasserIn  |4 aut 
700 1 |a Bossé, Yohan  |e VerfasserIn  |4 aut 
700 1 |a Lam, Stephen  |e VerfasserIn  |4 aut 
700 1 |a Tsao, Ming-Sound  |e VerfasserIn  |4 aut 
700 1 |a Tardon, Adonina  |e VerfasserIn  |4 aut 
700 1 |a Chen, Chu  |e VerfasserIn  |4 aut 
700 1 |a Doherty, Jennifer  |e VerfasserIn  |4 aut 
700 1 |a Goodman, Gary  |e VerfasserIn  |4 aut 
700 1 |a Bojesen, Stig E.  |e VerfasserIn  |4 aut 
700 1 |a Landi, Maria T.  |e VerfasserIn  |4 aut 
700 1 |a Johansson, Mattias  |e VerfasserIn  |4 aut 
700 1 |a Field, John K.  |e VerfasserIn  |4 aut 
700 1 |a Bickeböller, Heike  |e VerfasserIn  |4 aut 
700 1 |a Wichmann, H-Erich  |e VerfasserIn  |4 aut 
700 1 |a Risch, Angela  |e VerfasserIn  |0 (DE-588)1076185630  |0 (DE-627)834534401  |0 (DE-576)189151749  |4 aut 
700 1 |a Rennert, Gadi  |e VerfasserIn  |4 aut 
700 1 |a Arnold, Suzanne  |e VerfasserIn  |4 aut 
700 1 |a Wu, Xifeng  |e VerfasserIn  |4 aut 
700 1 |a Melander, Olle  |e VerfasserIn  |4 aut 
700 1 |a Brunnström, Hans  |e VerfasserIn  |4 aut 
700 1 |a Le Marchand, Loic  |e VerfasserIn  |4 aut 
700 1 |a Liu, Geoffrey  |e VerfasserIn  |4 aut 
700 1 |a Andrew, Angeline  |e VerfasserIn  |4 aut 
700 1 |a Duell, Eric  |e VerfasserIn  |4 aut 
700 1 |a Kiemeney, Lambertus A.  |e VerfasserIn  |4 aut 
700 1 |a Shen, Hongbing  |e VerfasserIn  |4 aut 
700 1 |a Haugen, Aage  |e VerfasserIn  |4 aut 
700 1 |a Johansson, Mikael  |e VerfasserIn  |4 aut 
700 1 |a Grankvist, Kjell  |e VerfasserIn  |4 aut 
700 1 |a Caporaso, Neil  |e VerfasserIn  |4 aut 
700 1 |a Woll, Penella  |e VerfasserIn  |4 aut 
700 1 |a Dawn Teare, M.  |e VerfasserIn  |4 aut 
700 1 |a Scelo, Ghislaine  |e VerfasserIn  |4 aut 
700 1 |a Hong, Yun-Chul  |e VerfasserIn  |4 aut 
700 1 |a Yuan, Jian-Min  |e VerfasserIn  |4 aut 
700 1 |a Lazarus, Philip  |e VerfasserIn  |4 aut 
700 1 |a Schabath, Matthew B.  |e VerfasserIn  |4 aut 
700 1 |a Aldrich, Melinda C.  |e VerfasserIn  |4 aut 
700 1 |a Albanes, Demetrios  |e VerfasserIn  |4 aut 
700 1 |a Mak, Raymond  |e VerfasserIn  |4 aut 
700 1 |a Barbie, David  |e VerfasserIn  |4 aut 
700 1 |a Brennan, Paul  |e VerfasserIn  |4 aut 
700 1 |a Hung, Rayjean J.  |e VerfasserIn  |4 aut 
700 1 |a Amos, Christopher I.  |e VerfasserIn  |4 aut 
700 1 |a Christiani, David C.  |e VerfasserIn  |4 aut 
700 1 |a Lin, Xihong  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Genetic epidemiology  |d New York, NY : Wiley-Liss, 1984  |g 45(2021), 1 vom: Jan., Seite 99-114  |h Online-Ressource  |w (DE-627)302922385  |w (DE-600)1492643-X  |w (DE-576)114617228  |x 1098-2272  |7 nnas  |a Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer 
773 1 8 |g volume:45  |g year:2021  |g number:1  |g month:01  |g pages:99-114  |g extent:16  |a Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer 
856 4 0 |u https://doi.org/10.1002/gepi.22358  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://onlinelibrary.wiley.com/doi/abs/10.1002/gepi.22358  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20251006 
993 |a Article 
994 |a 2021 
998 |g 1076185630  |a Risch, Angela  |m 1076185630:Risch, Angela  |d 50000  |e 50000PR1076185630  |k 0/50000/  |p 20 
999 |a KXP-PPN1937761304  |e 4781237827 
BIB |a Y 
SER |a journal 
JSO |a {"relHost":[{"title":[{"title_sort":"Genetic epidemiology","subtitle":"the official publication of the International Genetic Epidemiology Society","title":"Genetic epidemiology"}],"recId":"302922385","language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 28.02.08"],"disp":"Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancerGenetic epidemiology","part":{"issue":"1","pages":"99-114","year":"2021","extent":"16","volume":"45","text":"45(2021), 1 vom: Jan., Seite 99-114"},"pubHistory":["1.1984 -"],"id":{"doi":["10.1002/(ISSN)1098-2272"],"eki":["302922385"],"zdb":["1492643-X"],"issn":["1098-2272"]},"origin":[{"publisherPlace":"New York, NY","publisher":"Wiley-Liss","dateIssuedKey":"1984","dateIssuedDisp":"1984-"}],"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"16 S."}],"name":{"displayForm":["Ryan Sun, Miao Xu, Xihao Li, Sheila Gaynor, Hufeng Zhou, Zilin Li, Yohan Bossé, Stephen Lam, Ming-Sound Tsao, Adonina Tardon, Chu Chen, Jennifer Doherty, Gary Goodman, Stig E. Bojesen, Maria T. Landi, Mattias Johansson, John K. Field, Heike Bickeböller, H-Erich Wichmann, Angela Risch, Gadi Rennert, Suzanne Arnold, Xifeng Wu, Olle Melander, Hans Brunnström, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Eric Duell, Lambertus A. Kiemeney, Hongbing Shen, Aage Haugen, Mikael Johansson, Kjell Grankvist, Neil Caporaso, Penella Woll, M. Dawn Teare, Ghislaine Scelo, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Demetrios Albanes, Raymond Mak, David Barbie, Paul Brennan, Rayjean J. Hung, Christopher I. Amos, David C. Christiani, Xihong Lin"]},"id":{"eki":["1937761304"],"doi":["10.1002/gepi.22358"]},"origin":[{"dateIssuedDisp":"25 January 2021","dateIssuedKey":"2021"}],"language":["eng"],"recId":"1937761304","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Zuerst online veröffentlicht: 14. September 2020","Gesehen am 06.10.2025"],"person":[{"family":"Sun","given":"Ryan","roleDisplay":"VerfasserIn","display":"Sun, Ryan","role":"aut"},{"given":"Miao","family":"Xu","role":"aut","display":"Xu, Miao","roleDisplay":"VerfasserIn"},{"family":"Li","given":"Xihao","roleDisplay":"VerfasserIn","display":"Li, Xihao","role":"aut"},{"family":"Gaynor","given":"Sheila","roleDisplay":"VerfasserIn","display":"Gaynor, Sheila","role":"aut"},{"display":"Zhou, Hufeng","roleDisplay":"VerfasserIn","role":"aut","family":"Zhou","given":"Hufeng"},{"given":"Zilin","family":"Li","role":"aut","display":"Li, Zilin","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Bossé, Yohan","role":"aut","family":"Bossé","given":"Yohan"},{"role":"aut","display":"Lam, Stephen","roleDisplay":"VerfasserIn","given":"Stephen","family":"Lam"},{"display":"Tsao, Ming-Sound","roleDisplay":"VerfasserIn","role":"aut","family":"Tsao","given":"Ming-Sound"},{"role":"aut","display":"Tardon, Adonina","roleDisplay":"VerfasserIn","given":"Adonina","family":"Tardon"},{"role":"aut","display":"Chen, Chu","roleDisplay":"VerfasserIn","given":"Chu","family":"Chen"},{"family":"Doherty","given":"Jennifer","roleDisplay":"VerfasserIn","display":"Doherty, Jennifer","role":"aut"},{"role":"aut","display":"Goodman, Gary","roleDisplay":"VerfasserIn","given":"Gary","family":"Goodman"},{"display":"Bojesen, Stig E.","roleDisplay":"VerfasserIn","role":"aut","family":"Bojesen","given":"Stig E."},{"role":"aut","roleDisplay":"VerfasserIn","display":"Landi, Maria T.","given":"Maria T.","family":"Landi"},{"role":"aut","display":"Johansson, Mattias","roleDisplay":"VerfasserIn","given":"Mattias","family":"Johansson"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Field, John K.","given":"John K.","family":"Field"},{"family":"Bickeböller","given":"Heike","display":"Bickeböller, Heike","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Wichmann, H-Erich","roleDisplay":"VerfasserIn","given":"H-Erich","family":"Wichmann"},{"family":"Risch","given":"Angela","roleDisplay":"VerfasserIn","display":"Risch, Angela","role":"aut"},{"role":"aut","display":"Rennert, Gadi","roleDisplay":"VerfasserIn","given":"Gadi","family":"Rennert"},{"display":"Arnold, Suzanne","roleDisplay":"VerfasserIn","role":"aut","family":"Arnold","given":"Suzanne"},{"roleDisplay":"VerfasserIn","display":"Wu, Xifeng","role":"aut","family":"Wu","given":"Xifeng"},{"given":"Olle","family":"Melander","role":"aut","roleDisplay":"VerfasserIn","display":"Melander, Olle"},{"role":"aut","display":"Brunnström, Hans","roleDisplay":"VerfasserIn","given":"Hans","family":"Brunnström"},{"family":"Le Marchand","given":"Loic","roleDisplay":"VerfasserIn","display":"Le Marchand, Loic","role":"aut"},{"role":"aut","display":"Liu, Geoffrey","roleDisplay":"VerfasserIn","given":"Geoffrey","family":"Liu"},{"family":"Andrew","given":"Angeline","display":"Andrew, Angeline","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Eric","family":"Duell","role":"aut","roleDisplay":"VerfasserIn","display":"Duell, Eric"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Kiemeney, Lambertus A.","given":"Lambertus A.","family":"Kiemeney"},{"given":"Hongbing","family":"Shen","role":"aut","roleDisplay":"VerfasserIn","display":"Shen, Hongbing"},{"family":"Haugen","given":"Aage","roleDisplay":"VerfasserIn","display":"Haugen, Aage","role":"aut"},{"display":"Johansson, Mikael","roleDisplay":"VerfasserIn","role":"aut","family":"Johansson","given":"Mikael"},{"display":"Grankvist, Kjell","roleDisplay":"VerfasserIn","role":"aut","family":"Grankvist","given":"Kjell"},{"family":"Caporaso","given":"Neil","roleDisplay":"VerfasserIn","display":"Caporaso, Neil","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Woll, Penella","given":"Penella","family":"Woll"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Dawn Teare, M.","given":"M.","family":"Dawn Teare"},{"display":"Scelo, Ghislaine","roleDisplay":"VerfasserIn","role":"aut","family":"Scelo","given":"Ghislaine"},{"given":"Yun-Chul","family":"Hong","role":"aut","roleDisplay":"VerfasserIn","display":"Hong, Yun-Chul"},{"role":"aut","display":"Yuan, Jian-Min","roleDisplay":"VerfasserIn","given":"Jian-Min","family":"Yuan"},{"display":"Lazarus, Philip","roleDisplay":"VerfasserIn","role":"aut","family":"Lazarus","given":"Philip"},{"role":"aut","display":"Schabath, Matthew B.","roleDisplay":"VerfasserIn","given":"Matthew B.","family":"Schabath"},{"family":"Aldrich","given":"Melinda C.","roleDisplay":"VerfasserIn","display":"Aldrich, Melinda C.","role":"aut"},{"family":"Albanes","given":"Demetrios","display":"Albanes, Demetrios","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Raymond","family":"Mak","role":"aut","roleDisplay":"VerfasserIn","display":"Mak, Raymond"},{"family":"Barbie","given":"David","display":"Barbie, David","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Paul","family":"Brennan","role":"aut","roleDisplay":"VerfasserIn","display":"Brennan, Paul"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Hung, Rayjean J.","given":"Rayjean J.","family":"Hung"},{"family":"Amos","given":"Christopher I.","roleDisplay":"VerfasserIn","display":"Amos, Christopher I.","role":"aut"},{"given":"David C.","family":"Christiani","role":"aut","display":"Christiani, David C.","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Lin, Xihong","given":"Xihong","family":"Lin"}],"title":[{"title_sort":"Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer","title":"Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer"}]} 
SRT |a SUNRYANXUMINTEGRATIO2520 

Ähnliche Einträge