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Platelet adhesion and aggregate formation controlled by immobilised and soluble VWF

It has been demonstrated that von Willebrand factor (VWF) mediated platelet-endothelium and platelet-platelet interactions are shear dependent. The VWF’s mobility under dynamic conditions (e.g. flow) is pivotal to platelet adhesion and VWF-mediated aggregate formation in the cascade of VWF-platelet...

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Bibliographic Details
Main Authors: Schneider, Matthias F. (Author) , Fallah, Mohammad A. (Author) , Meß, Christian (Author) , Obser, Tobias (Author) , Schneppenheim, Reinhard (Author) , AlexanderKatz, Alfredo (Author) , Schneider, Stefan W. (Author) , Huck, Volker (Author)
Format: Article (Journal)
Language:English
Published: 11. September 2020
In: BMC molecular and cell biology
Year: 2020, Volume: 21, Pages: 113
ISSN:26618850
DOI:10.1186/s12860-020-00309-7
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12860-020-00309-7
Verlag, kostenfrei, Volltext: https://bmcmolcellbiol.biomedcentral.com/articles/10.1186/s12860-020-00309-7
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Author Notes:Matthias F. Schneider, Mohammad A. Fallah, Christian Mess, Tobias Obser, Reinhard Schneppenheim, Alfredo Alexander-Katz, Stefan W. Schneider and Volker Huck
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Summary:It has been demonstrated that von Willebrand factor (VWF) mediated platelet-endothelium and platelet-platelet interactions are shear dependent. The VWF’s mobility under dynamic conditions (e.g. flow) is pivotal to platelet adhesion and VWF-mediated aggregate formation in the cascade of VWF-platelet interactions in haemostasis.
Item Description:Gesehen am 13.10.2025
Physical Description:Online Resource
ISSN:26618850
DOI:10.1186/s12860-020-00309-7

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