Platelet adhesion and aggregate formation controlled by immobilised and soluble VWF
It has been demonstrated that von Willebrand factor (VWF) mediated platelet-endothelium and platelet-platelet interactions are shear dependent. The VWF’s mobility under dynamic conditions (e.g. flow) is pivotal to platelet adhesion and VWF-mediated aggregate formation in the cascade of VWF-platelet...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11. September 2020
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| In: |
BMC molecular and cell biology
Year: 2020, Jahrgang: 21, Pages: 113 |
| ISSN: | 26618850 |
| DOI: | 10.1186/s12860-020-00309-7 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12860-020-00309-7 Verlag, kostenfrei, Volltext: https://bmcmolcellbiol.biomedcentral.com/articles/10.1186/s12860-020-00309-7 
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| Verfasserangaben: | Matthias F. Schneider, Mohammad A. Fallah, Christian Mess, Tobias Obser, Reinhard Schneppenheim, Alfredo Alexander-Katz, Stefan W. Schneider and Volker Huck |
MARC
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| 520 | |a It has been demonstrated that von Willebrand factor (VWF) mediated platelet-endothelium and platelet-platelet interactions are shear dependent. The VWF’s mobility under dynamic conditions (e.g. flow) is pivotal to platelet adhesion and VWF-mediated aggregate formation in the cascade of VWF-platelet interactions in haemostasis. | ||
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| 650 | 4 | |a Primary haemostasis | |
| 650 | 4 | |a Shear activation | |
| 650 | 4 | |a Von Willebrand factor | |
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