Validating the predicted impact of HPV vaccination on HPV prevalence, cervical lesions, and cervical cancer: A systematic review of population level data and modelling studies
Background - We compared model predictions with independently published primary data from population-based studies on the impact of HPV vaccination on HPV prevalence, cervical cancer and its precursors. - Methods - We searched Cochrane Library, EMBASE, MEDLINE, Web of Science for studies concerning...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 2025
|
| In: |
Gynecologic oncology
Year: 2025, Jahrgang: 195, Pages: 134-143 |
| ISSN: | 1095-6859 |
| DOI: | 10.1016/j.ygyno.2025.03.008 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ygyno.2025.03.008 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0090825825000770 
|
| Verfasserangaben: | Daniël de Bondt, Emi Naslazi, Erik Jansen, Rachel Kupets, Bronwen McCurdy, Christine Stogios, Inge de Kok, Jan Hontelez |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 193846298X | ||
| 003 | DE-627 | ||
| 005 | 20251120193541.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251015s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ygyno.2025.03.008 |2 doi | |
| 035 | |a (DE-627)193846298X | ||
| 035 | |a (DE-599)KXP193846298X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bondt, Daniël D. de |e VerfasserIn |0 (DE-588)137902160X |0 (DE-627)1938464540 |4 aut | |
| 245 | 1 | 0 | |a Validating the predicted impact of HPV vaccination on HPV prevalence, cervical lesions, and cervical cancer |b A systematic review of population level data and modelling studies |c Daniël de Bondt, Emi Naslazi, Erik Jansen, Rachel Kupets, Bronwen McCurdy, Christine Stogios, Inge de Kok, Jan Hontelez |
| 264 | 1 | |c April 2025 | |
| 300 | |b Diagramme | ||
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.10.2025 | ||
| 520 | |a Background - We compared model predictions with independently published primary data from population-based studies on the impact of HPV vaccination on HPV prevalence, cervical cancer and its precursors. - Methods - We searched Cochrane Library, EMBASE, MEDLINE, Web of Science for studies concerning high-income countries published between 2005 to June 2, 2023. Relative risk (RR) for HPV-related outcomes comparing the pre-vaccination and post-vaccination periods were collected from observational and modelling studies. The relationship between vaccination coverage and observed relative reductions was determined using meta-regressions, and we compared model prediction to observations. - Findings - We identified a total of 5649 potential articles, of which one systematic review, 14 observational studies and 32 modelling studies met our inclusion criteria. A clear relation was found between the RR of HPV diseases related outcomes in the pre- versus post-vaccination era and the vaccination coverage, with 23 out of 28 data points and 19 out of 20 data points showing significant reductions in HPV prevalence and CIN2+ prevalence respectively. Around 67 % (n/N = 12/18) of model predictions were more optimistic on HPV prevalence reductions compared to the 95 % CI of the meta-regression derived from observational studies. For CIN2+ lesions, 48 % (n/N = 31/64) of model predictions for CIN2+ outcomes fell within the 95 % CI. - Interpretation - Model predictions and observational data agree that HPV vaccination can have a substantial impact on HPV related outcomes on a population level. Despite large heterogeneity in observational data and modelling studies, it is particularly encouraging that model predictions on the impact of HPV vaccination on CIN2+ model lesions align with observational studies. - Funding - Ontario Health (formerly known as Cancer Care Ontario). | ||
| 650 | 4 | |a Cervical cancer | |
| 650 | 4 | |a HPV vaccination | |
| 650 | 4 | |a meta-regression | |
| 700 | 1 | |a Naslazi, Emi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jansen, Erik |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kupets, Rachel |e VerfasserIn |4 aut | |
| 700 | 1 | |a McCurdy, Bronwen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stogios, Christine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kok, Inge de |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hontelez, Jan |e VerfasserIn |0 (DE-588)1140614843 |0 (DE-627)898610907 |0 (DE-576)493921583 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Gynecologic oncology |d Orlando, Fla. : Academic Press, 1972 |g 195(2025) vom: Apr., Seite 134-143 |h Online-Ressource |w (DE-627)266881351 |w (DE-600)1467974-7 |w (DE-576)104193735 |x 1095-6859 |7 nnas |a Validating the predicted impact of HPV vaccination on HPV prevalence, cervical lesions, and cervical cancer A systematic review of population level data and modelling studies |
| 773 | 1 | 8 | |g volume:195 |g year:2025 |g month:04 |g pages:134-143 |g extent:10 |a Validating the predicted impact of HPV vaccination on HPV prevalence, cervical lesions, and cervical cancer A systematic review of population level data and modelling studies |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ygyno.2025.03.008 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0090825825000770 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20251015 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1140614843 |a Hontelez, Jan |m 1140614843:Hontelez, Jan |d 910000 |d 912800 |e 910000PH1140614843 |e 912800PH1140614843 |k 0/910000/ |k 1/910000/912800/ |p 8 |y j | ||
| 999 | |a KXP-PPN193846298X |e 4787763768 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"10 S.","noteIll":"Diagramme"}],"relHost":[{"title":[{"title_sort":"Gynecologic oncology","subtitle":"an international journal ; official publication of the Society of Gynecologic Oncologists [u.a.]","title":"Gynecologic oncology"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 12.02.20"],"disp":"Validating the predicted impact of HPV vaccination on HPV prevalence, cervical lesions, and cervical cancer A systematic review of population level data and modelling studiesGynecologic oncology","language":["eng"],"corporate":[{"role":"isb","roleDisplay":"Herausgebendes Organ","display":"Society of Gynecologic Oncology"}],"recId":"266881351","pubHistory":["1.1972/73 -"],"part":{"pages":"134-143","year":"2025","extent":"10","text":"195(2025) vom: Apr., Seite 134-143","volume":"195"},"origin":[{"publisherPlace":"Orlando, Fla. ; Amsterdam [u.a.]","dateIssuedDisp":"1972-","publisher":"Academic Press ; Elsevier","dateIssuedKey":"1972"}],"id":{"issn":["1095-6859"],"eki":["266881351"],"zdb":["1467974-7"]},"physDesc":[{"extent":"Online-Ressource"}]}],"name":{"displayForm":["Daniël de Bondt, Emi Naslazi, Erik Jansen, Rachel Kupets, Bronwen McCurdy, Christine Stogios, Inge de Kok, Jan Hontelez"]},"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"April 2025"}],"id":{"eki":["193846298X"],"doi":["10.1016/j.ygyno.2025.03.008"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 15.10.2025"],"language":["eng"],"recId":"193846298X","person":[{"given":"Daniël D. de","family":"Bondt","role":"aut","display":"Bondt, Daniël D. de","roleDisplay":"VerfasserIn"},{"given":"Emi","family":"Naslazi","role":"aut","display":"Naslazi, Emi","roleDisplay":"VerfasserIn"},{"given":"Erik","family":"Jansen","role":"aut","display":"Jansen, Erik","roleDisplay":"VerfasserIn"},{"given":"Rachel","family":"Kupets","role":"aut","roleDisplay":"VerfasserIn","display":"Kupets, Rachel"},{"role":"aut","display":"McCurdy, Bronwen","roleDisplay":"VerfasserIn","given":"Bronwen","family":"McCurdy"},{"role":"aut","display":"Stogios, Christine","roleDisplay":"VerfasserIn","given":"Christine","family":"Stogios"},{"roleDisplay":"VerfasserIn","display":"Kok, Inge de","role":"aut","family":"Kok","given":"Inge de"},{"roleDisplay":"VerfasserIn","display":"Hontelez, Jan","role":"aut","family":"Hontelez","given":"Jan"}],"title":[{"title_sort":"Validating the predicted impact of HPV vaccination on HPV prevalence, cervical lesions, and cervical cancer","subtitle":"A systematic review of population level data and modelling studies","title":"Validating the predicted impact of HPV vaccination on HPV prevalence, cervical lesions, and cervical cancer"}]} | ||
| SRT | |a BONDTDANIEVALIDATING2025 | ||