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Thyroid hormone treatment for hypercholesterolemia in euthyroid patients: results from a European survey of thyroid specialists

Objective A relationship among hypothyroidism and lipid disorders is well established. However, current evidence and guidelines do not support the use of thyroid hormones (TH) in euthyroid patients with hyperlipidaemia as potential harms are considerable. This European survey investigated the use of...

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Main Authors: Galofré, Juan C. (Author) , Díez, Juan J. (Author) , Attanasio, Roberto (Author) , Nagy, Endre V. (Author) , Bednarczuk, Tomasz (Author) , Papini, Enrico (Author) , Žarković, Miloš (Author) , Negro, Roberto (Author) , Perros, Petros (Author) , Akarsu, Ersin (Author) , Alevizaki, Maria (Author) , Ayvaz, Göksun (Author) , Berta, Eszter (Author) , Beleslin, Biljana Nedeljković (Author) , Bodor, Miklos (Author) , Borissova, Anna Maria (Author) , Boyanov, Mihail (Author) , Burlacu, Maria-Cristina (Author) , Ćirić, Jasmina (Author) , Fadeyev, Valentin (Author) , Field, Benjamin C. T. (Author) , Führer, Dagmar (Author) , Jan, Jiskra (Author) , Kopp, Peter (Author) , Krebs, Michael (Author) , Kršek, Michal (Author) , Lazúrová, Ivica (Author) , Luchytskiy, Vitaliy (Author) , Puga, Francisca Marques (Author) , McGowan, Anne (Author) , Melo, Miguel (Author) , Metso, Saara (Author) , Moran, Carla (Author) , Morgunova, Tatyana (Author) , Niculescu, Dan Alexandru (Author) , Perić, Božidar (Author) , Planck, Tereza (Author) , Robenshtok, Eyal (Author) , Rosselet, Patrick Olivier (Author) , Ruchala, Marek (Author) , Shepelkevich, Alla (Author) , Tronko, Mykola (Author) , Unuane, David (Author) , Vardarli, Irfan (Author) , Visser, W Edward (Author) , Vryonidou, Andromachi (Author) , Younes, Younes R. (Author) , Hegedüs, Laszlo (Author)
Format: Article (Journal)
Language:English
Published: November 2025
In: Clinical endocrinology
Year: 2025, Volume: 103, Issue: 5, Pages: 749-756
ISSN:1365-2265
DOI:10.1111/cen.70014
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/cen.70014
Verlag, lizenzpflichtig, Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/cen.70014
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Author Notes:Juan C. Galofré, Juan J. Díez, Roberto Attanasio, Endre V. Nagy, Tomasz Bednarczuk, Enrico Papini, Miloš Žarković, Roberto Negro, Petros Perros, Ersin Akarsu, Maria Alevizaki, Göksun Ayvaz, Eszter Berta, Biljana Nedeljković Beleslin, Miklos Bodor, Anna Maria Borissova, Mihail Boyanov, Maria-Cristina Burlacu, Jasmina Ćirić, Valentin Fadeyev, Benjamin C.T. Field, Dagmar Führer, Jiskra Jan, Peter Kopp, Michael Krebs, Michal Kršek, Ivica Lazúrová, Vitaliy Luchytskiy, Francisca Marques Puga, Anne McGowan, Miguel Melo, Saara Metso, Carla Moran, Tatyana Morgunova, Dan Alexandru Niculescu, Božidar Perić, Tereza Planck, Eyal Robenshtok, Patrick Olivier Rosselet, Marek Ruchala, Alla Shepelkevich, Mykola Tronko, David Unuane, Irfan Vardarli, W Edward Visser, Andromachi Vryonidou, Younes R. Younes, Laszlo Hegedüs

MARC

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245 1 0 |a Thyroid hormone treatment for hypercholesterolemia in euthyroid patients  |b results from a European survey of thyroid specialists  |c Juan C. Galofré, Juan J. Díez, Roberto Attanasio, Endre V. Nagy, Tomasz Bednarczuk, Enrico Papini, Miloš Žarković, Roberto Negro, Petros Perros, Ersin Akarsu, Maria Alevizaki, Göksun Ayvaz, Eszter Berta, Biljana Nedeljković Beleslin, Miklos Bodor, Anna Maria Borissova, Mihail Boyanov, Maria-Cristina Burlacu, Jasmina Ćirić, Valentin Fadeyev, Benjamin C.T. Field, Dagmar Führer, Jiskra Jan, Peter Kopp, Michael Krebs, Michal Kršek, Ivica Lazúrová, Vitaliy Luchytskiy, Francisca Marques Puga, Anne McGowan, Miguel Melo, Saara Metso, Carla Moran, Tatyana Morgunova, Dan Alexandru Niculescu, Božidar Perić, Tereza Planck, Eyal Robenshtok, Patrick Olivier Rosselet, Marek Ruchala, Alla Shepelkevich, Mykola Tronko, David Unuane, Irfan Vardarli, W Edward Visser, Andromachi Vryonidou, Younes R. Younes, Laszlo Hegedüs 
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520 |a Objective A relationship among hypothyroidism and lipid disorders is well established. However, current evidence and guidelines do not support the use of thyroid hormones (TH) in euthyroid patients with hyperlipidaemia as potential harms are considerable. This European survey investigated the use of TH in euthyroid patients with severe hypercholesterolemia as a complementary treatment. Design Data were derived from the THESIS (Treatment of Hypothyroidism in Europe by Specialists) project that surveyed TH use. Univariable and multivariable analyses were used to explore associations. Results Out of 17,232 invitations, 5695 (33.0%) valid responses were received, and of these, 328 (5.8%) stated that TH are indicated in euthyroid patients with severe hypercholesterolemia. Univariable analyses disclosed significant differences and associations: (a) more non-endocrinologists (8.9%) than endocrinologist (5.4%) used TH (p < 0.001), (b) the number of hypothyroid patients treated per year was inversely related to use of TH (p = 0.024), (c) members of international endocrine/thyroid societies were more likely to use TH than non-members (p < 0.001), (d) significant variations by country and geographical region (p < 0.001), and (e) inverse relationship between gross national income per capita (GNIPC) and TH use (p < 0.001). Multivariable analyses yielded significant associations between use of TH, and male gender, specialty and GNIPC (p < 0.001). Conclusions This study suggests that a small but noteworthy minority of European thyroid specialists may be using TH to treat of severe hypercholesterolemia in euthyroid patients. If confirmed, this finding highlights the importance of raising awareness among thyroid specialists, professional societies, and healthcare providers to ensure adherence to evidence-based practices. 
650 4 |a euthyroidism 
650 4 |a hypercholesterolemia 
650 4 |a levothyroxine 
650 4 |a misuse 
650 4 |a treatment 
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700 1 |a Shepelkevich, Alla  |e VerfasserIn  |4 aut 
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