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Clinical practice in European centres treating paediatric posterior fossa tumours with pencil beam scanning proton therapy

Background and purpose - As no guidelines for pencil beam scanning (PBS) proton therapy (PT) of paediatric posterior fossa (PF) tumours exist to date, this study investigated planning techniques across European PT centres, with special considerations for brainstem and spinal cord sparing. - Material...

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Main Authors: Toussaint, Laura (Author) , Matysiak, Witold (Author) , Alapetite, Claire (Author) , Aristu, Javier (Author) , Bannink-Gawryszuk, Agata (Author) , Bolle, Stephanie (Author) , Bolsi, Alessandra (Author) , Calvo, Felipe (Author) , Cerron Campoo, Fernando (Author) , Charlwood, Frances (Author) , Demoor-Goldschmidt, Charlotte (Author) , Doyen, Jérôme (Author) , Drosik-Rutowicz, Katarzyna (Author) , Dutheil, Pauline (Author) , Embring, Anna (Author) , Engellau, Jacob (Author) , Goedgebeur, Anneleen (Author) , Goudjil, Farid (Author) , Harrabi, Semi B. (Author) , Kopec, Renata (Author) , Kristensen, Ingrid (Author) , Lægsdmand, Peter (Author) , Lütgendorf-Caucig, Carola (Author) , Meijers, Arturs (Author) , Mirandola, Alfredo (Author) , Missohou, Fernand (Author) , Montero Feijoo, Marta (Author) , Muren, Ludvig P. (Author) , Ondrova, Barbora (Author) , Orlandi, Ester (Author) , Pettersson, Erik (Author) , Pica, Alessia (Author) , Plaude, Sandija (Author) , Righetto, Roberto (Author) , Rombi, Barbara (Author) , Timmermann, Beate (Author) , Van Beek, Karen (Author) , Vela, Anthony (Author) , Vennarini, Sabina (Author) , Vestergaard, Anne (Author) , Vidal, Marie (Author) , Vondracek, Vladimir (Author) , Weber, Damien C. (Author) , Whitfield, Gillian (Author) , Zimmerman, Jens (Author) , Maduro, John H. (Author) , Lassen-Ramshad, Yasmin (Author)
Format: Article (Journal)
Language:English
Published: September 2024
In: Radiotherapy and oncology
Year: 2024, Volume: 198, Pages: 1-8
ISSN:1879-0887
DOI:10.1016/j.radonc.2024.110414
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.radonc.2024.110414
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814024006844
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Author Notes:Laura Toussaint, Witold Matysiak, Claire Alapetite, Javier Aristu, Agata Bannink-Gawryszuk, Stephanie Bolle, Alessandra Bolsi, Felipe Calvo, Fernando Cerron Campoo, Frances Charlwood, Charlotte Demoor-Goldschmidt, Jérôme Doyen, Katarzyna Drosik-Rutowicz, Pauline Dutheil, Anna Embring, Jacob Engellau, Anneleen Goedgebeur, Farid Goudjil, Semi Harrabi, Renata Kopec, Ingrid Kristensen, Peter Lægsdmand, Carola Lütgendorf-Caucig, Arturs Meijers, Alfredo Mirandola, Fernand Missohou, Marta Montero Feijoo, Ludvig P. Muren, Barbora Ondrova, Ester Orlandi, Erik Pettersson, Alessia Pica, Sandija Plaude, Roberto Righetto, Barbara Rombi, Beate Timmermann, Karen Van Beek, Anthony Vela, Sabina Vennarini, Anne Vestergaard, Marie Vidal, Vladimir Vondracek, Damien C. Weber, Gillian Whitfield, Jens Zimmerman, John H. Maduro, Yasmin Lassen-Ramshad
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Summary:Background and purpose - As no guidelines for pencil beam scanning (PBS) proton therapy (PT) of paediatric posterior fossa (PF) tumours exist to date, this study investigated planning techniques across European PT centres, with special considerations for brainstem and spinal cord sparing. - Materials and methods - A survey and a treatment planning comparison were initiated across nineteen European PBS-PT centres treating paediatric patients. The survey assessed all aspects of the treatment chain, including but not limited to delineations, dose constraints and treatment planning. Each centre planned two PF tumour cases for focal irradiation, according to their own clinical practice but based on common delineations. The prescription dose was 54 Gy(RBE) for Case 1 and 59.4 Gy(RBE) for Case 2. For both cases, planning strategies and relevant dose metrics were compared. - Results - Seventeen (89 %) centres answered the survey, and sixteen (80 %) participated in the treatment planning comparison. In the survey, thirteen (68 %) centres reported using the European Particle Therapy Network definition for brainstem delineation. In the treatment planning study, while most centres used three beam directions, their configurations varied widely across centres. Large variations were also seen in brainstem doses, with a brainstem near maximum dose (D2%) ranging from 52.7 Gy(RBE) to 55.7 Gy(RBE) (Case 1), and from 56.8 Gy(RBE) to 60.9 Gy(RBE) (Case 2). - Conclusion - This study assessed the European PBS-PT planning of paediatric PF tumours. Agreement was achieved in e.g. delineation-practice, while wider variations were observed in planning approach and consequently dose to organs at risk. Collaboration between centres is still ongoing, striving towards common guidelines.
Item Description:Online verfügbar: 26. Juni 2024, Artikelversion: 29. Juni 2024
Gesehen am 20.10.2025
Physical Description:Online Resource
ISSN:1879-0887
DOI:10.1016/j.radonc.2024.110414

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