Role of defense/immunity proteins in non-obstructive azoospermia: insights from gene expression and single-cell RNA sequencing analyses
Non-obstructive azoospermia (NOA) is a severe form of male infertility characterized by a complete absence of sperm in the ejaculate due to impaired spermatogenesis. While genetic and hormonal factors are known contributors, recent evidence highlights the role of immune dysregulation in NOA pathophy...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 June 2025
|
| In: |
Reproductive sciences
Year: 2025, Jahrgang: 32, Heft: 7, Pages: 2484-2498 |
| ISSN: | 1933-7205 |
| DOI: | 10.1007/s43032-025-01916-5 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s43032-025-01916-5
|
| Verfasserangaben: | Ali Shakeri Abroudi, Hossein Azizi, Melika Djamali, Hewa Khalid Abdullah, Ali Qorbanee, Thomas Skutella |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1938877659 | ||
| 003 | DE-627 | ||
| 005 | 20251127235743.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251020s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s43032-025-01916-5 |2 doi | |
| 035 | |a (DE-627)1938877659 | ||
| 035 | |a (DE-599)KXP1938877659 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Abroudi, Ali Shakeri |e VerfasserIn |0 (DE-588)1379368014 |0 (DE-627)1938878973 |4 aut | |
| 245 | 1 | 0 | |a Role of defense/immunity proteins in non-obstructive azoospermia |b insights from gene expression and single-cell RNA sequencing analyses |c Ali Shakeri Abroudi, Hossein Azizi, Melika Djamali, Hewa Khalid Abdullah, Ali Qorbanee, Thomas Skutella |
| 264 | 1 | |c 19 June 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 19. Juni 2025 | ||
| 500 | |a Gesehen am 20.10.2025 | ||
| 520 | |a Non-obstructive azoospermia (NOA) is a severe form of male infertility characterized by a complete absence of sperm in the ejaculate due to impaired spermatogenesis. While genetic and hormonal factors are known contributors, recent evidence highlights the role of immune dysregulation in NOA pathophysiology. Defense/immunity proteins play a crucial role in maintaining testicular immune homeostasis, but their aberrant expression may contribute to spermatogenic failure. This study analyzed gene expression data from multiple datasets to identify immune-related genes significantly altered in NOA, including IFITM1, CES1, MR1, LSAMP, PRB2, CARD8, and PECAM1. Differential expression analysis revealed upregulation of IFITM1 and PECAM1 and downregulation of CES1, MR1, LSAMP, PRB2, and CARD8, suggesting immune imbalance and oxidative stress contribute to NOA pathogenesis. Additionally, single-cell RNA sequencing confirmed their differential expression in distinct testicular cell populations. Our findings suggest that immune-related pathways, including cytokine signaling, antigen processing, and oxidative stress response, may contribute to NOA pathogenesis. Targeting these molecular pathways could provide novel therapeutic strategies for improving reproductive outcomes in affected individuals. | ||
| 650 | 4 | |a Defense/immunity proteins | |
| 650 | 4 | |a Male infertility | |
| 650 | 4 | |a Non-obstructive azoospermia | |
| 650 | 4 | |a Spermatogenesis | |
| 650 | 4 | |a Testicular immune response | |
| 700 | 1 | |8 1\p |a Azizi, Hossein |e VerfasserIn |0 (DE-588)1058210386 |0 (DE-627)796582572 |0 (DE-576)414246004 |4 aut | |
| 700 | 1 | |a Djamali, Melika |e VerfasserIn |4 aut | |
| 700 | 1 | |a Abdullah, Hewa Khalid |e VerfasserIn |4 aut | |
| 700 | 1 | |a Qorbanee, Ali |e VerfasserIn |4 aut | |
| 700 | 1 | |a Skutella, Thomas |d 1963- |e VerfasserIn |0 (DE-588)120568225 |0 (DE-627)080752047 |0 (DE-576)180448390 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Reproductive sciences |d Cham : Springer Nature Switzerland AG, 2007 |g 32(2025), 7, Seite 2484-2498 |h Online-Ressource |w (DE-627)523194854 |w (DE-600)2266096-3 |w (DE-576)276818342 |x 1933-7205 |7 nnas |a Role of defense/immunity proteins in non-obstructive azoospermia insights from gene expression and single-cell RNA sequencing analyses |
| 773 | 1 | 8 | |g volume:32 |g year:2025 |g number:7 |g pages:2484-2498 |g extent:15 |a Role of defense/immunity proteins in non-obstructive azoospermia insights from gene expression and single-cell RNA sequencing analyses |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s43032-025-01916-5 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20251101 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20251020 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 120568225 |a Skutella, Thomas |m 120568225:Skutella, Thomas |d 50000 |d 53100 |e 50000PS120568225 |e 53100PS120568225 |k 0/50000/ |k 1/50000/53100/ |p 6 |y j | ||
| 999 | |a KXP-PPN1938877659 |e 4789788784 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"recId":"523194854","origin":[{"publisherPlace":"Cham ; Thousand Oaks, Calif.","dateIssuedKey":"2007","dateIssuedDisp":"2007-","publisher":"Springer Nature Switzerland AG ; Sage"}],"titleAlt":[{"title":"RS"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 23.04.2020"],"disp":"Role of defense/immunity proteins in non-obstructive azoospermia insights from gene expression and single-cell RNA sequencing analysesReproductive sciences","id":{"eki":["523194854"],"zdb":["2266096-3"],"issn":["1933-7205"]},"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["14.2007 -"],"language":["eng"],"part":{"pages":"2484-2498","extent":"15","issue":"7","volume":"32","year":"2025","text":"32(2025), 7, Seite 2484-2498"},"title":[{"subtitle":"RS : the official journal of the Society for Reproductive Investigation","title":"Reproductive sciences","title_sort":"Reproductive sciences"}]}],"note":["Online veröffentlicht: 19. Juni 2025","Gesehen am 20.10.2025"],"id":{"eki":["1938877659"],"doi":["10.1007/s43032-025-01916-5"]},"physDesc":[{"noteIll":"Illustrationen","extent":"15 S."}],"origin":[{"dateIssuedDisp":"19 June 2025","dateIssuedKey":"2025"}],"recId":"1938877659","type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"family":"Abroudi","display":"Abroudi, Ali Shakeri","given":"Ali Shakeri","role":"aut"},{"given":"Hossein","role":"aut","display":"Azizi, Hossein","family":"Azizi"},{"display":"Djamali, Melika","role":"aut","given":"Melika","family":"Djamali"},{"family":"Abdullah","display":"Abdullah, Hewa Khalid","given":"Hewa Khalid","role":"aut"},{"family":"Qorbanee","display":"Qorbanee, Ali","given":"Ali","role":"aut"},{"role":"aut","given":"Thomas","display":"Skutella, Thomas","family":"Skutella"}],"name":{"displayForm":["Ali Shakeri Abroudi, Hossein Azizi, Melika Djamali, Hewa Khalid Abdullah, Ali Qorbanee, Thomas Skutella"]},"language":["eng"],"title":[{"subtitle":"insights from gene expression and single-cell RNA sequencing analyses","title":"Role of defense/immunity proteins in non-obstructive azoospermia","title_sort":"Role of defense/immunity proteins in non-obstructive azoospermia"}]} | ||
| SRT | |a ABROUDIALIROLEOFDEFE1920 | ||