Modeling how iso-caloric macronutrient substitutions are longitudinally associated with plasma kynurenines in colorectal cancer survivors up to 12 months post-treatment
Dietary intake of several macronutrients is associated with plasma kynurenines after colorectal cancer (CRC), and kynurenines have been linked to health-related outcomes. It is unknown how macronutrient substitution affects plasma kynurenines, which may be relevant for developing guidelines to impro...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 2025
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| In: |
The journal of nutritional biochemistry
Year: 2025, Jahrgang: 141, Pages: 1-10 |
| ISSN: | 1873-4847 |
| DOI: | 10.1016/j.jnutbio.2025.109910 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.jnutbio.2025.109910 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0955286325000737 
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| Verfasserangaben: | Daniëlle D. B. Holthuijsen, Eline H. van Roekel, Martijn J. L. Bours, Per M. Ueland, Stéphanie O. Breukink, Maryska L. G. Janssen-Heijnen, Joop L. Konsten, Eric T. P. Keulen, Adrian McCann, Stefanie Brezina, Biljana Gigic, Dieuwertje E. Kok, Cornelia M. Ulrich, Matty P. Weijenberg, Simone J. P. M. Eussen |
MARC
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| 245 | 1 | 0 | |a Modeling how iso-caloric macronutrient substitutions are longitudinally associated with plasma kynurenines in colorectal cancer survivors up to 12 months post-treatment |c Daniëlle D. B. Holthuijsen, Eline H. van Roekel, Martijn J. L. Bours, Per M. Ueland, Stéphanie O. Breukink, Maryska L. G. Janssen-Heijnen, Joop L. Konsten, Eric T. P. Keulen, Adrian McCann, Stefanie Brezina, Biljana Gigic, Dieuwertje E. Kok, Cornelia M. Ulrich, Matty P. Weijenberg, Simone J. P. M. Eussen |
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| 520 | |a Dietary intake of several macronutrients is associated with plasma kynurenines after colorectal cancer (CRC), and kynurenines have been linked to health-related outcomes. It is unknown how macronutrient substitution affects plasma kynurenines, which may be relevant for developing guidelines to improve post-CRC quality of life through dietary changes. Using iso-caloric substitution models, we investigated how substituting one macronutrient with another is longitudinally associated with plasma tryptophan, kynurenines, and kynurenine ratios in CRC survivors. Measurements were performed at 6-weeks, 6-months, and 12-months post-treatment in 247 stage I-III CRC survivors. Macronutrient intake was measured by 7-d dietary records and plasma kynurenines by LC/MS-MS. For analysis, we applied linear mixed models with false discovery rate (FDR) to adjust for multiple testing. After FDR adjustment, substituting 100 kcal/d of total carbohydrates with 100 kcal/d of total protein was associated with higher plasma concentrations of kynurenic acid (KA), xanthurenic acid (XA), and a higher kynurenic acid-to-quinolinic acid (KA/QA) ratio. Substituting 100 kcal/d of total carbohydrates with 100 kcal/d of total fat was associated with higher tryptophan concentrations, higher KA/QA ratio, and a lower kynurenine-to-tryptophan ratio (KTR) and hydroxykynurenine ratio (HKr). Substituting 100 kcal/d of total fat with 100 kcal/d of total protein was associated with higher XA concentrations. Altogether, iso-caloric macronutrient substitutions, particularly substituting carbohydrates with protein or fat, were longitudinally associated with higher concentrations of potentially favourable kynurenines and ratios (i.e., KA, XA, and KA/QA ratio) and lower ratios with pro-inflammatory or neurotoxic properties (i.e., KTR and HKr) in CRC survivors up to 12-months post-treatment. | ||
| 650 | 4 | |a Colorectal cancer survivorship | |
| 650 | 4 | |a Dietary intake | |
| 650 | 4 | |a Macronutrient replacement | |
| 650 | 4 | |a Macronutrient substitution | |
| 650 | 4 | |a Plasma kynurenines | |
| 700 | 1 | |a van Roekel, Eline H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bours, Martijn J. L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ueland, Per M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Breukink, Stéphanie O. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Janssen-Heijnen, Maryska L. G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Konsten, Joop L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Keulen, Eric T. P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a McCann, Adrian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brezina, Stefanie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gigić, Biljana |d 1978- |e VerfasserIn |0 (DE-588)1124096310 |0 (DE-627)877817561 |0 (DE-576)482295201 |4 aut | |
| 700 | 1 | |a Kok, Dieuwertje E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ulrich, Cornelia M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weijenberg, Matty P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Eussen, Simone J. P. M. |e VerfasserIn |4 aut | |
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