Dynamic handgrip exercise for the detection of myocardial ischemia using fast Strain-ENCoded cardiovascular magnetic resonance
Background - Previous data suggest dynamic handgrip exercise (DHE) as a potential physiological, needle-free stressor feasible for cardiovascular magnetic resonance (CMR) examinations. DHE-fast Strain-ENCoded imaging (fSENC) is potentially cost-saving, ultra-fast and avoids pharmacological side effe...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
Sum 2025
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| In: |
Journal of cardiovascular magnetic resonance
Year: 2025, Jahrgang: 27, Heft: 1, Pages: 1-10 |
| ISSN: | 1532-429X |
| DOI: | 10.1016/j.jocmr.2025.101879 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.jocmr.2025.101879 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1097664725000419 
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| Verfasserangaben: | Andreas Ochs, Michael Nippes, Janek Salatzki, Lukas D. Weberling, Nael Osman, Johannes Riffel, Hugo A. Katus, Matthias G. Friedrich, Norbert Frey, Marco M. Ochs, Florian André |
MARC
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| 245 | 1 | 0 | |a Dynamic handgrip exercise for the detection of myocardial ischemia using fast Strain-ENCoded cardiovascular magnetic resonance |c Andreas Ochs, Michael Nippes, Janek Salatzki, Lukas D. Weberling, Nael Osman, Johannes Riffel, Hugo A. Katus, Matthias G. Friedrich, Norbert Frey, Marco M. Ochs, Florian André |
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| 520 | |a Background - Previous data suggest dynamic handgrip exercise (DHE) as a potential physiological, needle-free stressor feasible for cardiovascular magnetic resonance (CMR) examinations. DHE-fast Strain-ENCoded imaging (fSENC) is potentially cost-saving, ultra-fast and avoids pharmacological side effects thereby targeting the drawbacks of conventional pharmacological stress CMR. - Objectives - To assess the diagnostic accuracy of DHE-fSENC for detecting ischemia-related wall motion abnormalities in suspected obstructive coronary artery disease (CAD). - Methods - Patients with known or suspected obstructive CAD referred for CMR stress testing were prospectively enrolled. Diagnostic accuracy was assessed in comparison to pharmacological stress CMR and in a subgroup, compared to invasive coronary angiography (ICA). The CMR protocol was extended by both-handed DHE with 80 repetitions per minute over 2 min followed by fSENC short-axis acquisition before pharmacological stress testing. Stress-induced impairment of regional longitudinal strain was graded suspicious for obstructive CAD. - Results - Two-hundred sixty individuals with cardiovascular high-risk profile (64±13years, 75% male) were enrolled. DHE-fSENC provided a sensitivity of 79% (95% CI: 64-89) and specificity of 87% (95% CI 82-91) compared to pharmacological stress CMR. In a subgroup of 105 patients with recent ICA, high diagnostic accuracy was found for the detection of obstructive CAD (sensitivity 82% [95% CI: 67-92], specificity 89% [95% CI: 78-95]). Exam duration of DHE-fSENC was significantly reduced compared to conventional CMR stress protocols (DHE-fSENC 207±69 s vs. adenosine-perfusion 287±82 s vs. dobutamine-cine 1132±294 s, all p<0.001). - Conclusion - DHE-fSENC allows for a reliable and fast detection of obstructive CAD, thereby expanding the applicability of needle-free CMR stress testing. | ||
| 650 | 4 | |a CMR | |
| 650 | 4 | |a FSENC | |
| 650 | 4 | |a Handgrip | |
| 650 | 4 | |a Ischemia | |
| 650 | 4 | |a Longitudinal strain | |
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