Research communication: effects of screening colonoscopy on colorectal cancer mortality : lessons from comparative analyses of randomised trials
NordICC, the first randomised trial on long-term effects of screening colonoscopy, failed to demonstrate a significant reduction in colorectal cancer (CRC) mortality. We compared reported 10-year CRC mortality results from NordICC with those of NORCCAP, a similarly designed pragmatic sigmoidoscopy t...
Gespeichert in:
| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
Sep 2025
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| In: |
Alimentary pharmacology & therapeutics
Year: 2025, Jahrgang: 62, Heft: 6, Pages: 656-659 |
| ISSN: | 1365-2036 |
| DOI: | 10.1111/apt.70231 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/apt.70231 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/apt.70231 
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| Verfasserangaben: | Hermann Brenner, Dmitry Sergeev, Thomas Heisser, Michael Hoffmeister |
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| 520 | |a NordICC, the first randomised trial on long-term effects of screening colonoscopy, failed to demonstrate a significant reduction in colorectal cancer (CRC) mortality. We compared reported 10-year CRC mortality results from NordICC with those of NORCCAP, a similarly designed pragmatic sigmoidoscopy trial. In NORCCAP, differences in CRC mortality only began to emerge after 9.5 years of follow-up, rapidly increased thereafter and were approximately 4-fold as high after 12 years than after 10 years. Other sigmoidoscopy trials yielded similar 11- to 12-year results. Our analysis suggests that the apparent negative CRC mortality results of NordICC primarily reflect insufficient follow-up time. | ||
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