Pacemaker versus defibrillator therapy in patients eligible for cardiac resynchronisation therapy: evidence from the German Device Registry
Background: According to current guidelines, cardiac resynchronisation therapy (CRT) is recommended in patients with significantly impaired left ventricular systolic function and left bundle branch block. However, the decision between pacemaker (CRT-P) and defibrillator (CRT-D) in patients eligible...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 February 2025
|
| In: |
Journal of Clinical Medicine
Year: 2025, Jahrgang: 14, Heft: 4, Pages: 1-10 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm14041137 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/jcm14041137 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2077-0383/14/4/1137 
|
| Verfasserangaben: | Philipp S. Lange, Gerrit Frommeyer, Thomas Kleemann, Johannes Brachmann, Patrick Lugenbiel, Sebastian Reif, Matthias Hochadel, Jochen Senges and Lars Eckardt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1939184479 | ||
| 003 | DE-627 | ||
| 005 | 20251209025558.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251023s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/jcm14041137 |2 doi | |
| 035 | |a (DE-627)1939184479 | ||
| 035 | |a (DE-599)KXP1939184479 | ||
| 035 | |a (OCoLC)1559713286 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lange, Philipp Sebastian |d 1974- |e VerfasserIn |0 (DE-588)123970601 |0 (DE-627)706492315 |0 (DE-576)29396436X |4 aut | |
| 245 | 1 | 0 | |a Pacemaker versus defibrillator therapy in patients eligible for cardiac resynchronisation therapy |b evidence from the German Device Registry |c Philipp S. Lange, Gerrit Frommeyer, Thomas Kleemann, Johannes Brachmann, Patrick Lugenbiel, Sebastian Reif, Matthias Hochadel, Jochen Senges and Lars Eckardt |
| 264 | 1 | |c 10 February 2025 | |
| 300 | |b Diagramme | ||
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 23.10.2025 | ||
| 520 | |a Background: According to current guidelines, cardiac resynchronisation therapy (CRT) is recommended in patients with significantly impaired left ventricular systolic function and left bundle branch block. However, the decision between pacemaker (CRT-P) and defibrillator (CRT-D) in patients eligible for CRT remains a matter of debate. Register data have shown a higher all-cause mortality in CRT-P in comparison to patients with a CRT-D. Here, we investigated clinical determinants of the selection of CRT-P vs. CRT-D and clinical outcome in large registry data from a multi-centre ‘real-life’ registry on patients with CRT defibrillator or pacemaker therapy. Methods: The German Device Registry (DEVICE) is a nationwide, prospective registry with one-year follow-up investigating 5451 patients receiving device implantations in 50 German centres. The present analysis of DEVICE focused on all patients from the register receiving cardiac resynchronization therapy. Results: Out of 1603 patients receiving cardiac resynchronisation therapy, 1536 (95.8%) received a CRT defibrillator system and 67 (4.2%) a CRT pacemaker system. Patients in the CRT-P group had a significantly better left ventricular systolic function compared to the CRT-D group (median 35% vs. 25%), and significantly less often had a history of myocardial infarction (9.0% vs. 25.2%). A preexisting pacemaker and a history of stroke/peripheral embolism were identified as determinants for the selection of CRT-P vs. CRT-D. Overall mortality after one-year follow-up was 8.0%. Patients with ischemic cardiomyopathy receiving CRT-P therapy had a higher one-year mortality than patients receiving CRT-D (21.2% vs. 8.9%, p = 0.020). On the other hand, patients with non-ischemic cardiomyopathy did not display differences between these two treatment groups (CRT-P 8.1%, CRT-D 6.6%, p = 0.72). Conclusions: Data from the German device registry show that most patients receiving cardiac synchronization therapy have an implanted CRT-D system. In comparison to patients with CRT-D, those with CRT-P more often had a non-ischemic cardiomyopathy and a preexisting pacemaker system. The outcomes between these two treatment groups were different as regards ischemic cardiomyopathy only. | ||
| 650 | 4 | |a cardiac resynchronization therapy | |
| 650 | 4 | |a cardiovascular mortality | |
| 650 | 4 | |a German device registry | |
| 650 | 4 | |a ICD implantation | |
| 700 | 1 | |a Frommeyer, Gerrit |d 1985- |e VerfasserIn |0 (DE-588)1016198868 |0 (DE-627)671234021 |0 (DE-576)351644466 |4 aut | |
| 700 | 1 | |a Kleemann, Thomas |d 1970- |e VerfasserIn |0 (DE-588)123322375 |0 (DE-627)706255038 |0 (DE-576)161728162 |4 aut | |
| 700 | 1 | |a Brachmann, Johannes |e VerfasserIn |0 (DE-588)171987209 |0 (DE-627)696882957 |0 (DE-576)132863677 |4 aut | |
| 700 | 1 | |a Lugenbiel, Patrick |d 1982- |e VerfasserIn |0 (DE-588)137855710 |0 (DE-627)696120062 |0 (DE-576)305349414 |4 aut | |
| 700 | 1 | |a Reif, Sebastian |d 1976- |e VerfasserIn |0 (DE-588)130402559 |0 (DE-627)501113002 |0 (DE-576)189962356 |4 aut | |
| 700 | 1 | |a Hochadel, Matthias |e VerfasserIn |0 (DE-588)1128413051 |0 (DE-627)88289871X |0 (DE-576)485901811 |4 aut | |
| 700 | 1 | |a Senges, Jochen |d 1942- |e VerfasserIn |0 (DE-588)1027133479 |0 (DE-627)728326620 |0 (DE-576)372508685 |4 aut | |
| 700 | 1 | |a Eckardt, Lars |d 1969- |e VerfasserIn |0 (DE-588)172952743 |0 (DE-627)697879364 |0 (DE-576)133806669 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of Clinical Medicine |d Basel : MDPI, 2012 |g 14(2025), 4, Artikel-ID 1137, Seite 1-10 |h Online-Ressource |w (DE-627)718632478 |w (DE-600)2662592-1 |w (DE-576)365782718 |x 2077-0383 |7 nnas |a Pacemaker versus defibrillator therapy in patients eligible for cardiac resynchronisation therapy evidence from the German Device Registry |
| 773 | 1 | 8 | |g volume:14 |g year:2025 |g number:4 |g elocationid:1137 |g pages:1-10 |g extent:10 |a Pacemaker versus defibrillator therapy in patients eligible for cardiac resynchronisation therapy evidence from the German Device Registry |
| 856 | 4 | 0 | |u https://doi.org/10.3390/jcm14041137 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.mdpi.com/2077-0383/14/4/1137 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20251023 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1027133479 |a Senges, Jochen |m 1027133479:Senges, Jochen |d 50000 |e 50000PS1027133479 |k 0/50000/ |p 8 | ||
| 998 | |g 137855710 |a Lugenbiel, Patrick |m 137855710:Lugenbiel, Patrick |d 910000 |d 910100 |d 50000 |e 910000PL137855710 |e 910100PL137855710 |e 50000PL137855710 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 5 | ||
| 999 | |a KXP-PPN1939184479 |e 4790873226 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"title":[{"title_sort":"Pacemaker versus defibrillator therapy in patients eligible for cardiac resynchronisation therapy","title":"Pacemaker versus defibrillator therapy in patients eligible for cardiac resynchronisation therapy","subtitle":"evidence from the German Device Registry"}],"relHost":[{"id":{"eki":["718632478"],"issn":["2077-0383"],"zdb":["2662592-1"]},"recId":"718632478","physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.2012 -"],"note":["Gesehen am 12.06.20"],"title":[{"title":"Journal of Clinical Medicine","title_sort":"Journal of Clinical Medicine","subtitle":"open access journal"}],"origin":[{"dateIssuedDisp":"2012-","publisherPlace":"Basel","dateIssuedKey":"2012","publisher":"MDPI"}],"disp":"Pacemaker versus defibrillator therapy in patients eligible for cardiac resynchronisation therapy evidence from the German Device RegistryJournal of Clinical Medicine","part":{"issue":"4","year":"2025","extent":"10","volume":"14","pages":"1-10","text":"14(2025), 4, Artikel-ID 1137, Seite 1-10"},"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"10 February 2025"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.3390/jcm14041137"],"eki":["1939184479"]},"recId":"1939184479","name":{"displayForm":["Philipp S. Lange, Gerrit Frommeyer, Thomas Kleemann, Johannes Brachmann, Patrick Lugenbiel, Sebastian Reif, Matthias Hochadel, Jochen Senges and Lars Eckardt"]},"person":[{"family":"Lange","given":"Philipp Sebastian","roleDisplay":"VerfasserIn","role":"aut","display":"Lange, Philipp Sebastian"},{"display":"Frommeyer, Gerrit","role":"aut","roleDisplay":"VerfasserIn","given":"Gerrit","family":"Frommeyer"},{"display":"Kleemann, Thomas","role":"aut","roleDisplay":"VerfasserIn","given":"Thomas","family":"Kleemann"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Brachmann, Johannes","family":"Brachmann","given":"Johannes"},{"role":"aut","display":"Lugenbiel, Patrick","roleDisplay":"VerfasserIn","family":"Lugenbiel","given":"Patrick"},{"display":"Reif, Sebastian","role":"aut","roleDisplay":"VerfasserIn","family":"Reif","given":"Sebastian"},{"display":"Hochadel, Matthias","role":"aut","roleDisplay":"VerfasserIn","family":"Hochadel","given":"Matthias"},{"roleDisplay":"VerfasserIn","display":"Senges, Jochen","role":"aut","given":"Jochen","family":"Senges"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Eckardt, Lars","given":"Lars","family":"Eckardt"}],"physDesc":[{"noteIll":"Diagramme","extent":"10 S."}],"note":["Gesehen am 23.10.2025"]} | ||
| SRT | |a LANGEPHILIPACEMAKERV1020 | ||