Mucosal tenascin C content in inflammatory and neoplastic diseases of the large bowel
PURPOSE: Tenascin C is a glycoprotein of the extracellular matrix. It is upregulated during embryologic development, wound healing, and under conditions of normal and neoplastic growth. Most available data on tenascin C expression in tissues is based on immunohistologic studies. The present study wa...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 1998
|
| In: |
Diseases of the colon & rectum
Year: 1998, Jahrgang: 41, Heft: 1, Pages: 86-92 |
| ISSN: | 1530-0358 |
| DOI: | 10.1007/BF02236901 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF02236901
|
| Verfasserangaben: | Stefan Riedl, Martina Kadmon, Andrea Tandara, Ulf Hinz, Peter Möller, Christian Herfarth, Andreas Faissner |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1939344433 | ||
| 003 | DE-627 | ||
| 005 | 20251023123952.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251023s1998 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/BF02236901 |2 doi | |
| 035 | |a (DE-627)1939344433 | ||
| 035 | |a (DE-599)KXP1939344433 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Riedl, Stefan |e VerfasserIn |0 (DE-588)110656765X |0 (DE-627)863176046 |0 (DE-576)474249522 |4 aut | |
| 245 | 1 | 0 | |a Mucosal tenascin C content in inflammatory and neoplastic diseases of the large bowel |c Stefan Riedl, Martina Kadmon, Andrea Tandara, Ulf Hinz, Peter Möller, Christian Herfarth, Andreas Faissner |
| 264 | 1 | |c January 1998 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 23.10.2025 | ||
| 520 | |a PURPOSE: Tenascin C is a glycoprotein of the extracellular matrix. It is upregulated during embryologic development, wound healing, and under conditions of normal and neoplastic growth. Most available data on tenascin C expression in tissues is based on immunohistologic studies. The present study was designed to quantify tissue concentrations in patients with inflammatory and neoplastic diseases of the large bowel. METHODS: Fifty patients with ulcerative colitis, 19 patients suffering from familiar adenomatous polyposis without malignant transformation, and 69 patients with colorectal carcinoma were investigated. Tenascin C concentrations in tissue extracts were determined by semiquantitative Western blotting. RESULTS: The tenascin C tissue concentration of normal mucosa was 2.6±3.4 µg/mg (n=55), 2.9±2.1 µg/mg in colorectal adenomas (n=19), 7.5±4.7 µg/mg in ulcerative colitis (n=50), and 18±15 µg/mg in colorectal carcinomas (n=69; mean ± standard deviation). In ulcerative colitis, the mucosal tenascin C content correlated with histopathologic disease activity. No differences were found between subgroups of adenomas or carcinomas. CONCLUSIONS: Tenascin C tissue concentrations were not altered in adenomas, slightly elevated in ulcerative colitis, and substantially increased in colorectal carcinomas. Although less useful as a diagnostic parameter, tenascin C tissue levels serve as an instrument for assessing the activity of stromal remodeling in largebowel diseases generally. Specifically, they may reflect disease activity in ulcerative colitis. | ||
| 650 | 4 | |a Colon adenoma | |
| 650 | 4 | |a Colon carcinoma | |
| 650 | 4 | |a Tenascin C | |
| 650 | 4 | |a Tissue concentration | |
| 650 | 4 | |a Ulcerative colitis | |
| 700 | 1 | |a Kadmon, Martina |d 1961- |e VerfasserIn |0 (DE-588)115093419 |0 (DE-627)644710055 |0 (DE-576)174135343 |4 aut | |
| 700 | 1 | |a Tandara, Andrea |d 1970- |e VerfasserIn |0 (DE-588)122978412 |0 (DE-627)706115007 |0 (DE-576)293504563 |4 aut | |
| 700 | 1 | |a Hinz, Ulf |e VerfasserIn |0 (DE-588)1022150499 |0 (DE-627)716927748 |0 (DE-576)175505284 |4 aut | |
| 700 | 1 | |a Möller, Peter |d 1952- |e VerfasserIn |0 (DE-588)111360638X |0 (DE-627)86765788X |0 (DE-576)477016235 |4 aut | |
| 700 | 1 | |a Herfarth, Christian |d 1933-2014 |e VerfasserIn |0 (DE-588)120706385 |0 (DE-627)080841562 |0 (DE-576)213333414 |4 aut | |
| 700 | 1 | |a Faissner, Andreas |e VerfasserIn |0 (DE-588)110080173 |0 (DE-627)691069492 |0 (DE-576)341126225 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Diseases of the colon & rectum |d Hagerstown, Md. : Lippincott Williams & Wilkins, 1958 |g 41(1998), 1, Seite 86-92 |h Online-Ressource |w (DE-627)329270540 |w (DE-600)2046914-7 |w (DE-576)097188824 |x 1530-0358 |7 nnas |a Mucosal tenascin C content in inflammatory and neoplastic diseases of the large bowel |
| 773 | 1 | 8 | |g volume:41 |g year:1998 |g number:1 |g pages:86-92 |g extent:7 |a Mucosal tenascin C content in inflammatory and neoplastic diseases of the large bowel |
| 856 | 4 | 0 | |u https://doi.org/10.1007/BF02236901 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20251023 | ||
| 993 | |a Article | ||
| 994 | |a 1998 | ||
| 998 | |g 120706385 |a Herfarth, Christian |m 120706385:Herfarth, Christian |d 910000 |d 910200 |e 910000PH120706385 |e 910200PH120706385 |k 0/910000/ |k 1/910000/910200/ |p 6 | ||
| 998 | |g 111360638X |a Möller, Peter |m 111360638X:Möller, Peter |p 5 | ||
| 998 | |g 1022150499 |a Hinz, Ulf |m 1022150499:Hinz, Ulf |d 910000 |d 910200 |e 910000PH1022150499 |e 910200PH1022150499 |k 0/910000/ |k 1/910000/910200/ |p 4 | ||
| 998 | |g 122978412 |a Tandara, Andrea |m 122978412:Tandara, Andrea |d 50000 |e 50000PT122978412 |k 0/50000/ |p 3 | ||
| 998 | |g 115093419 |a Kadmon, Martina |m 115093419:Kadmon, Martina |d 910000 |d 910200 |e 910000PK115093419 |e 910200PK115093419 |k 0/910000/ |k 1/910000/910200/ |p 2 | ||
| 998 | |g 110656765X |a Riedl, Stefan |m 110656765X:Riedl, Stefan |d 910000 |d 910200 |e 910000PR110656765X |e 910200PR110656765X |k 0/910000/ |k 1/910000/910200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1939344433 |e 4790964876 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 23.10.2025"],"relHost":[{"title":[{"title":"Diseases of the colon & rectum","subtitle":"DC&R ; official journal of the American Society of Colon and Rectal Surgeons","title_sort":"Diseases of the colon & rectum"}],"corporate":[{"role":"isb","display":"American Society of Colon and Rectal Surgeons"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Hagerstown, Md. ; New York, NY ; Philadelphia, Pa. ; New York, NY","publisher":"Lippincott Williams & Wilkins ; Ovid Technologies Inc. ; Lippincott Williams & Wilkins ; Springer","dateIssuedKey":"1958","dateIssuedDisp":"1958-"}],"id":{"eki":["329270540"],"zdb":["2046914-7"],"issn":["1530-0358"]},"recId":"329270540","disp":"Mucosal tenascin C content in inflammatory and neoplastic diseases of the large bowelDiseases of the colon & rectum","titleAlt":[{"title":"DC&R"}],"note":["Gesehen am 18.12.14"],"pubHistory":["1.1958 -"],"part":{"year":"1998","issue":"1","text":"41(1998), 1, Seite 86-92","extent":"7","volume":"41","pages":"86-92"}}],"person":[{"family":"Riedl","role":"aut","given":"Stefan","display":"Riedl, Stefan"},{"given":"Martina","role":"aut","family":"Kadmon","display":"Kadmon, Martina"},{"family":"Tandara","given":"Andrea","role":"aut","display":"Tandara, Andrea"},{"given":"Ulf","role":"aut","family":"Hinz","display":"Hinz, Ulf"},{"display":"Möller, Peter","family":"Möller","given":"Peter","role":"aut"},{"family":"Herfarth","given":"Christian","role":"aut","display":"Herfarth, Christian"},{"family":"Faissner","given":"Andreas","role":"aut","display":"Faissner, Andreas"}],"title":[{"title":"Mucosal tenascin C content in inflammatory and neoplastic diseases of the large bowel","title_sort":"Mucosal tenascin C content in inflammatory and neoplastic diseases of the large bowel"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"physDesc":[{"extent":"7 S."}],"id":{"eki":["1939344433"],"doi":["10.1007/BF02236901"]},"origin":[{"dateIssuedDisp":"January 1998","dateIssuedKey":"1998"}],"name":{"displayForm":["Stefan Riedl, Martina Kadmon, Andrea Tandara, Ulf Hinz, Peter Möller, Christian Herfarth, Andreas Faissner"]},"recId":"1939344433"} | ||
| SRT | |a RIEDLSTEFAMUCOSALTEN1998 | ||