Genetic association of ACE2 rs2285666 (C>T) and rs2106809 (A>G) and susceptibility to SARS-CoV-2 infection among the Ghanaian population
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), enters human cells using the angiotensin-converting enzyme 2 (ACE-2) receptor. ACE2 single nucleotide polymorphisms (SNPs) can influence susceptibility by affecting viral binding or gene expression. This study investigated the a...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
26 May 2025
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| In: |
Frontiers in genetics
Year: 2025, Volume: 16, Pages: 1-13 |
| ISSN: | 1664-8021 |
| DOI: | 10.3389/fgene.2025.1555515 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fgene.2025.1555515 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1555515/full 
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| Author Notes: | Alexander Owusu Boakye, Christian Obirikorang, Anthony Afum-Adjei Awuah, Evans Asamoah Adu, Doris Winter, Eric Ebenezer Boham, Hakim Alani, Sylvester Kofi Newton, Nana Safi Toure Almoustapha, James Deke, Welbeck Odame Dzadey, Louis Adu-Amoah, Sally-Ann Kroduah, Mary Ama Grant, Gracelyn Asare, Amos Amoako-Adusei, Wibke Loag, Jenny Kettenbeil, Yaw Adu Sarkodie, Ebenezer Oduro-Mensah, Alfred Edwin Yawson, Stephen Apanga, Rose Odotei Adjei, Austin Gideon Adobasom-Anane, Eva Lorenz, Aurélia Souares, Oumou Maiga-Ascofaré, Jürgen May, Nicole S. Struck and John Humphery Amuasi |
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| 245 | 1 | 0 | |a Genetic association of ACE2 rs2285666 (C>T) and rs2106809 (A>G) and susceptibility to SARS-CoV-2 infection among the Ghanaian population |c Alexander Owusu Boakye, Christian Obirikorang, Anthony Afum-Adjei Awuah, Evans Asamoah Adu, Doris Winter, Eric Ebenezer Boham, Hakim Alani, Sylvester Kofi Newton, Nana Safi Toure Almoustapha, James Deke, Welbeck Odame Dzadey, Louis Adu-Amoah, Sally-Ann Kroduah, Mary Ama Grant, Gracelyn Asare, Amos Amoako-Adusei, Wibke Loag, Jenny Kettenbeil, Yaw Adu Sarkodie, Ebenezer Oduro-Mensah, Alfred Edwin Yawson, Stephen Apanga, Rose Odotei Adjei, Austin Gideon Adobasom-Anane, Eva Lorenz, Aurélia Souares, Oumou Maiga-Ascofaré, Jürgen May, Nicole S. Struck and John Humphery Amuasi |
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| 520 | |a BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), enters human cells using the angiotensin-converting enzyme 2 (ACE-2) receptor. ACE2 single nucleotide polymorphisms (SNPs) can influence susceptibility by affecting viral binding or gene expression. This study investigated the association between ACE2 SNPs, rs2285666 and rs2106809, and the SARS-CoV-2 infection susceptibility in a Ghanaian population.MethodsGenomic DNA was extracted, using a magnetic bead-based method, from blood samples of a random-subset of 1,334 participants drawn from a two-stage cluster, population-based household cross-sectional SARS-CoV-2 IgG seroprevalence survey. Data collected included, socio-demographic characteristics, medical history, vaccination, and smoking status. Genotyping of the ACE2 SNPs was performed using Allele-Specific Oligonucleotide Polymerase Chain Reaction (ASO-PCR) combined with melting curve analysis. Logistic regression models were utilized to assess the association between the ACE2 SNPs and the susceptibility to SARS-CoV-2 infectionResultsThe median age of participants was 33 [Interquartile range (IQR) = 24-46] years. Females accounted for the majority of the sampled population, 64.3%. SARS-CoV-2-IgG seropositivity was (58.4%, 95%CI: 52.6%-64.2%) among the male population and (54.1%, 95%CI: 49.54%-58.61%) in the female population. There were no significant differences in overall allele or genotype frequencies of ACE2 SNPs between SARS-CoV-2 IgG seropositive and seronegative individuals for both females and males. Among females, those with the T allele of ACE2 rs2285666 had a 38% decreased susceptibility to SARS-CoV-2 infection under the dominant [adjusted odds ratio (aOR) = 0.62; 95%CI = 0.45-0.85, P = 0.003] and heterozygous advantage models (aOR = 0.62; 95%CI = 0.45-0.86, P = 0.004), after adjusting for confounders, but not thee recessive model (aOR = 0.41; 95%CI = 0.03-5.22, P = 0.490). No significant association was observed among males. Overall, the ACE2 rs2106809 was not associated with the susceptibility to SARS-CoV-2 infection in both males and females.ConclusionThis study found no association between ACE2 rs2106809 genetic variant and susceptibility to SARS-CoV-2 infection, whilst the rs2285666 T-allele was associated with a decreased frequency for SARS-CoV-2 infection among Ghanaian females. These findings enhance our understanding of genetic factors influencing SARS-CoV-2 susceptibility, which could help identify at-risk populations and inform more targeted public health interventions in future outbreaks. | ||
| 650 | 4 | |a angiotensin-converting enzyme 2 (ACE2) | |
| 650 | 4 | |a candidate gene association study (CGAS) | |
| 650 | 4 | |a genetic epidemiological study | |
| 650 | 4 | |a SARS-CoV-2 infection (COVID-19) | |
| 650 | 4 | |a SARS-CoV-2 susceptibility | |
| 650 | 4 | |a single nucleotide polymorphism (SNP) | |
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| 700 | 1 | |a Boham, Eric Ebenezer |e VerfasserIn |4 aut | |
| 700 | 1 | |a Alani, Hakim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Newton, Sylvester Kofi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Almoustapha, Nana Safi Toure |e VerfasserIn |4 aut | |
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