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Tranexamic acid in radical cystectomy: a systematic review and meta-analysis of efficacy and safety

Radical cystectomy (RC) is a high-risk procedure, associated with significant bleeding and high risk of perioperative blood transfusion (PBT), which may limit clinical and oncological outcomes. Tranexamic acid (TXA), an antifibrinolytic agent, effectively reduces bleeding in various surgical setting...

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Main Authors: Mangold, Maurin Helen (Author) , Wieland, Victoria (Author) , Grilli, Maurizio (Author) , Studier-Fischer, Alexander (Author) , Haney, Caelán Max (Author) , Westhoff, Niklas Christian (Author) , Michel, Maurice Stephan (Author) , Egen, Luisa (Author) , Kowalewski, Karl-Friedrich (Author)
Format: Article (Journal)
Language:English
Published: 18 September 2025
In: World journal of urology
Year: 2025, Volume: 43, Issue: 1, Pages: 1-10
ISSN:1433-8726
DOI:10.1007/s00345-025-05939-0
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00345-025-05939-0
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00345-025-05939-0
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Author Notes:Maurin Helen Mangold, Victoria Luise Simone Wieland, Maurizio Grilli, Alexander Studier-Fischer, Caelán Max Haney-Aubert, Niklas Westhoff, Maurice Stephan Michel, Luisa Egen, Karl-Friedrich Kowalewski
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Summary:Radical cystectomy (RC) is a high-risk procedure, associated with significant bleeding and high risk of perioperative blood transfusion (PBT), which may limit clinical and oncological outcomes. Tranexamic acid (TXA), an antifibrinolytic agent, effectively reduces bleeding in various surgical settings; however, its role in RC remains understudied. This systematic review and meta-analysis evaluates the efficacy and safety of TXA in RC patients.
Item Description:Gesehen am 27.10.2025
Physical Description:Online Resource
ISSN:1433-8726
DOI:10.1007/s00345-025-05939-0

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