rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Thalamic deep brain stimulation for dystonic head tremor
    sub title: a long-term study of 18 patients : clinical practice
  name:
    name part: Nagel, Johanna Maria
    role:
      role term: creator
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Wolf, Marc
    name part: 1979-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Blahak, Christian
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Runge, Joachim
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Schrader, Christoph
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Dressler, Dirk
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Saryyeva, Assel
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Krauss, Joachim K.
    role:
      role term: VerfasserIn
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: xx
    date issued: 2025
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: Illustrationen, Diagramme
    extent: 11
  abstract: Background Dystonic head tremor is a particular manifestation of dystonia, which is difficult to treat. Although deep brain stimulation (DBS) of the globus pallidus internus has been established as a treatment for different phenotypes of dystonia, its role in dystonic tremor has been debated. Although thalamic targets have been used for treatment of dystonic tremor of the extremities, there is limited experience with dystonic head tremor. Objectives Here, we present our experience with thalamic ventral intermediate (Vim) nucleus DBS in a consecutive series of patients providing long-term follow-up. Methods Eighteen patients with dystonic head tremor as the leading symptom underwent the implantation of quadripolar DBS electrodes into the thalamic Vim. Patients' symptoms were evaluated with the Burke-Fahn-Marsden Dystonia Rating Scale motor (BFMDRS-M) and disability (BFMDRS-D) scores, and a modified Fahn-Tolosa-Marin Tremor Rating Scale (mFTMTRS), preoperatively, at short-term (3 months-2 years), and at long-term follow-up (>2 years). Results There was improvement in both tremor and dystonia rating scales. Tremor scores were reduced from a value of 7.94 preoperatively to 2.0 at short term (P < 0.001) and to 1.71 at long-term follow-up (P < 0.001). BFMDRS-M scores were reduced from 14.56 to 7.8 (P < 0.001) and to 7.0 (P < 0.001), and BFMDRS-D scores from 3.88 to 2.65 (P < 0.05) and to 2.71 (P < 0.05), respectively, during chronic stimulation. Conclusions Our results indicate that Vim DBS is a safe and efficient treatment option for dystonic head tremor with stable long-term results. We suggest Vim DBS as an alternative to pallidal DBS in cases where head tremor is the leading symptom.
  note: Johanna M. Nagel, MD, Marc E. Wolf, MD, Christian Blahak, MD, Joachim Runge, MD, Christoph Schrader, MD, Dirk Dressler, MD, Assel Saryyeva, MD, and Joachim K. Krauss, MD
  note: Erstmals veröffentlicht: 27. August 2025
  note: Gesehen am 28.10.2025
  subject:
    topic: cervical dystonia
  subject:
    topic: deep brain stimulation
  subject:
    topic: dystonia
  subject:
    topic: head tremor
  subject:
    topic: thalamus
  subject:
    topic: ventral intermediate nucleus
  classification: 33
  related item:
    title info:
      title: Movement disorders clinical practice
    name:
      name part: Thalamic deep brain stimulation for dystonic head tremor a long-term study of 18 patients : clinical practice
    origin info:
      publisher: New York, NY : Wiley, 2014
    physical description:
      extent: Online-Ressource
    identifier: 2330-1619
    identifier: (DE-627)787023191
    identifier: (DE-600)2772809-2
    identifier: (DE-576)407572260
    part:
      text: 13(2026), 1, Seite 131-141
  related item:
    name:
      name part: Thalamic deep brain stimulation for dystonic head tremor a long-term study of 18 patients : clinical practice
    part:
      text: volume:13
    part:
      text: year:2026
    part:
      text: number:1
    part:
      text: pages:131-141
    part:
      text: extent:11
  identifier: https://doi.org/10.1002/mdc3.70266
  identifier: https://onlinelibrary.wiley.com/doi/abs/10.1002/mdc3.70266
  record info:
    record content source: DE-627
    record creation date: 251028
    record change date: 20260320132542.0
    record identifier: 1939564530
    language of cataloging:
      language term: ger