Advanced automated model for robust bone marrow segmentation in whole-body MRI
Rationale and Objectives - To establish an advanced automated bone marrow (BM) segmentation model on whole-body (WB-)MRI in monoclonal plasma cell disorders (MPCD), and to demonstrate its robust performance on multicenter datasets with severe myeloma-related pathologies. - Materials and Methods - Th...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2025
|
| In: |
Academic radiology
Year: 2025, Jahrgang: 32, Heft: 5, Pages: 2824-2835 |
| ISSN: | 1878-4046 |
| DOI: | 10.1016/j.acra.2024.12.060 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.acra.2024.12.060 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1076633224010481 
|
| Verfasserangaben: | Fabian Bauer, Jessica Kächele, Juliane Bernhard, Marina Hajiyianni, Niels Weinhold, Sandra Sauer, Martin Grözinger, Marc-Steffen Raab, Elias K. Mai, Tim F. Weber, Hartmut Goldschmidt, Heinz-Peter Schlemmer, Klaus Maier-Hein, Stefan Delorme, Peter Neher, Markus Wennmann |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 194016835X | ||
| 003 | DE-627 | ||
| 005 | 20251104133519.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251104s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.acra.2024.12.060 |2 doi | |
| 035 | |a (DE-627)194016835X | ||
| 035 | |a (DE-599)KXP194016835X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bauer, Fabian |d 1997- |e VerfasserIn |0 (DE-588)129260848X |0 (DE-627)1848855710 |4 aut | |
| 245 | 1 | 0 | |a Advanced automated model for robust bone marrow segmentation in whole-body MRI |c Fabian Bauer, Jessica Kächele, Juliane Bernhard, Marina Hajiyianni, Niels Weinhold, Sandra Sauer, Martin Grözinger, Marc-Steffen Raab, Elias K. Mai, Tim F. Weber, Hartmut Goldschmidt, Heinz-Peter Schlemmer, Klaus Maier-Hein, Stefan Delorme, Peter Neher, Markus Wennmann |
| 264 | 1 | |c May 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 22. Januar 2025, Artikelversion: 19. April 2025 | ||
| 500 | |a Gesehen am 04.11.2025 | ||
| 520 | |a Rationale and Objectives - To establish an advanced automated bone marrow (BM) segmentation model on whole-body (WB-)MRI in monoclonal plasma cell disorders (MPCD), and to demonstrate its robust performance on multicenter datasets with severe myeloma-related pathologies. - Materials and Methods - The study cohort comprised multi-vendor, multi-protocol imaging data acquired with varying field strength across 8 different centers. In total, 210 WB-MRIs of 207 MPCD patients were included. An nnU-Net algorithm was established for segmenting the individual bone marrow spaces (BMS) of the spine, pelvis, humeri and femora (advanced segmentation model). For this task, 186 T1-weighted (T1w) WB-MRIs from center 1 were used in the training set. Test sets included 12 T1w WB-MRIs from center 2 (I) and 9 T1w WB-MRIs from centers 3-8 (II). Example cases were included to showcase segmentation performance on T1w WB-MRIs with extensive tumor load. The segmentation accuracy of the advanced segmentation model was compared to a prior established basic segmentation model by calculating Dice scores and using the Wilcoxon signed-rank test. - Results - The mean Dice score on the individual BMS was 0.89±0.13 (test set I) and 0.88±0.11 (test set II), significantly higher than the Dice scores of a prior basic model (p<0.05). Dice scores for the BMS of the individual bones ranged from 0.77 to 0.96 (test set I), and 0.81 to 0.95 (test set II). BM altered by myeloma-relevant pathologies, artifacts or low imaging quality was precisely segmented. - Conclusion - The advanced model performed reliable, automated segmentations, even on heterogeneously acquired multicenter WB-MRIs with severe pathologies. | ||
| 650 | 4 | |a Deep Learning | |
| 650 | 4 | |a Magnetic Resonance Imaging | |
| 650 | 4 | |a Multiple Myeloma | |
| 650 | 4 | |a Segmentation | |
| 700 | 1 | |a Kächele, Jessica |e VerfasserIn |0 (DE-588)1380711754 |0 (DE-627)194017094X |4 aut | |
| 700 | 1 | |a Bernhard, Juliane |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hajiyianni, Marina |e VerfasserIn |0 (DE-588)1337479535 |0 (DE-627)1897203470 |4 aut | |
| 700 | 1 | |a Weinhold, Niels |e VerfasserIn |0 (DE-588)141225688 |0 (DE-627)626149576 |0 (DE-576)322607388 |4 aut | |
| 700 | 1 | |a Sauer, Sandra |d 1975- |e VerfasserIn |0 (DE-588)1060031140 |0 (DE-627)799171778 |0 (DE-576)416132855 |4 aut | |
| 700 | 1 | |a Grözinger, Martin |d 1986- |e VerfasserIn |0 (DE-588)1201131006 |0 (DE-627)1684418054 |4 aut | |
| 700 | 1 | |a Raab, Marc-Steffen |d 1973- |e VerfasserIn |0 (DE-588)124052460 |0 (DE-627)706520998 |0 (DE-576)293998027 |4 aut | |
| 700 | 1 | |a Mai, Elias K. |d 1985- |e VerfasserIn |0 (DE-588)1049182545 |0 (DE-627)781300274 |0 (DE-576)403130999 |4 aut | |
| 700 | 1 | |a Weber, Tim |d 1977- |e VerfasserIn |0 (DE-588)133392694 |0 (DE-627)544045017 |0 (DE-576)299816613 |4 aut | |
| 700 | 1 | |a Goldschmidt, Hartmut |d 1956- |e VerfasserIn |0 (DE-588)102258023X |0 (DE-627)717003809 |0 (DE-576)365637386 |4 aut | |
| 700 | 1 | |a Schlemmer, Heinz-Peter |d 1961- |e VerfasserIn |0 (DE-588)1025559967 |0 (DE-627)722927142 |0 (DE-576)17334805X |4 aut | |
| 700 | 1 | |a Maier-Hein, Klaus H. |d 1980- |e VerfasserIn |0 (DE-588)1100551875 |0 (DE-627)85946461X |0 (DE-576)333771222 |4 aut | |
| 700 | 1 | |a Delorme, Stefan |e VerfasserIn |0 (DE-588)105842808X |0 (DE-627)796879761 |0 (DE-576)179470140 |4 aut | |
| 700 | 1 | |a Neher, Peter |d 1984- |e VerfasserIn |0 (DE-588)1052246052 |0 (DE-627)788077287 |0 (DE-576)408004746 |4 aut | |
| 700 | 1 | |a Wennmann, Markus |d 1992- |e VerfasserIn |0 (DE-588)1188436317 |0 (DE-627)1667380931 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Academic radiology |d Philadelphia, PA [u.a.] : Elsevier, 1994 |g 32(2025), 5, Seite 2824-2835 |h Online-Ressource |w (DE-627)331018667 |w (DE-600)2050425-1 |w (DE-576)271497602 |x 1878-4046 |7 nnas |a Advanced automated model for robust bone marrow segmentation in whole-body MRI |
| 773 | 1 | 8 | |g volume:32 |g year:2025 |g number:5 |g pages:2824-2835 |g extent:12 |a Advanced automated model for robust bone marrow segmentation in whole-body MRI |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.acra.2024.12.060 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1076633224010481 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20251104 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1188436317 |a Wennmann, Markus |m 1188436317:Wennmann, Markus |d 50000 |e 50000PW1188436317 |k 0/50000/ |p 16 |y j | ||
| 998 | |g 1052246052 |a Neher, Peter |m 1052246052:Neher, Peter |d 910000 |d 911400 |e 910000PN1052246052 |e 911400PN1052246052 |k 0/910000/ |k 1/910000/911400/ |p 15 | ||
| 998 | |g 105842808X |a Delorme, Stefan |m 105842808X:Delorme, Stefan |d 50000 |e 50000PD105842808X |k 0/50000/ |p 14 | ||
| 998 | |g 1100551875 |a Maier-Hein, Klaus H. |m 1100551875:Maier-Hein, Klaus H. |d 910000 |d 911400 |e 910000PM1100551875 |e 911400PM1100551875 |k 0/910000/ |k 1/910000/911400/ |p 13 | ||
| 998 | |g 1025559967 |a Schlemmer, Heinz-Peter |m 1025559967:Schlemmer, Heinz-Peter |p 12 | ||
| 998 | |g 102258023X |a Goldschmidt, Hartmut |m 102258023X:Goldschmidt, Hartmut |d 910000 |d 910100 |e 910000PG102258023X |e 910100PG102258023X |k 0/910000/ |k 1/910000/910100/ |p 11 | ||
| 998 | |g 133392694 |a Weber, Tim |m 133392694:Weber, Tim |d 50000 |e 50000PW133392694 |k 0/50000/ |p 10 | ||
| 998 | |g 1049182545 |a Mai, Elias K. |m 1049182545:Mai, Elias K. |d 910000 |d 910100 |d 50000 |e 910000PM1049182545 |e 910100PM1049182545 |e 50000PM1049182545 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 9 | ||
| 998 | |g 124052460 |a Raab, Marc-Steffen |m 124052460:Raab, Marc-Steffen |d 910000 |d 910100 |e 910000PR124052460 |e 910100PR124052460 |k 0/910000/ |k 1/910000/910100/ |p 8 | ||
| 998 | |g 1201131006 |a Grözinger, Martin |m 1201131006:Grözinger, Martin |d 50000 |e 50000PG1201131006 |k 0/50000/ |p 7 | ||
| 998 | |g 1060031140 |a Sauer, Sandra |m 1060031140:Sauer, Sandra |d 910000 |d 910100 |e 910000PS1060031140 |e 910100PS1060031140 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 141225688 |a Weinhold, Niels |m 141225688:Weinhold, Niels |d 910000 |d 910100 |d 50000 |e 910000PW141225688 |e 910100PW141225688 |e 50000PW141225688 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 5 | ||
| 998 | |g 1337479535 |a Hajiyianni, Marina |m 1337479535:Hajiyianni, Marina |d 910000 |d 910100 |e 910000PH1337479535 |e 910100PH1337479535 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1380711754 |a Kächele, Jessica |m 1380711754:Kächele, Jessica |d 50000 |e 50000PK1380711754 |k 0/50000/ |p 2 | ||
| 999 | |a KXP-PPN194016835X |e 4796106235 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1016/j.acra.2024.12.060"],"eki":["194016835X"]},"name":{"displayForm":["Fabian Bauer, Jessica Kächele, Juliane Bernhard, Marina Hajiyianni, Niels Weinhold, Sandra Sauer, Martin Grözinger, Marc-Steffen Raab, Elias K. Mai, Tim F. Weber, Hartmut Goldschmidt, Heinz-Peter Schlemmer, Klaus Maier-Hein, Stefan Delorme, Peter Neher, Markus Wennmann"]},"note":["Online verfügbar: 22. Januar 2025, Artikelversion: 19. April 2025","Gesehen am 04.11.2025"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"title":[{"title_sort":"Advanced automated model for robust bone marrow segmentation in whole-body MRI","title":"Advanced automated model for robust bone marrow segmentation in whole-body MRI"}],"person":[{"display":"Bauer, Fabian","role":"aut","given":"Fabian","family":"Bauer"},{"given":"Jessica","role":"aut","family":"Kächele","display":"Kächele, Jessica"},{"role":"aut","given":"Juliane","family":"Bernhard","display":"Bernhard, Juliane"},{"display":"Hajiyianni, Marina","role":"aut","given":"Marina","family":"Hajiyianni"},{"family":"Weinhold","given":"Niels","role":"aut","display":"Weinhold, Niels"},{"family":"Sauer","role":"aut","given":"Sandra","display":"Sauer, Sandra"},{"family":"Grözinger","role":"aut","given":"Martin","display":"Grözinger, Martin"},{"role":"aut","given":"Marc-Steffen","family":"Raab","display":"Raab, Marc-Steffen"},{"display":"Mai, Elias K.","given":"Elias K.","role":"aut","family":"Mai"},{"role":"aut","given":"Tim","family":"Weber","display":"Weber, Tim"},{"display":"Goldschmidt, Hartmut","family":"Goldschmidt","role":"aut","given":"Hartmut"},{"display":"Schlemmer, Heinz-Peter","role":"aut","given":"Heinz-Peter","family":"Schlemmer"},{"family":"Maier-Hein","role":"aut","given":"Klaus H.","display":"Maier-Hein, Klaus H."},{"family":"Delorme","given":"Stefan","role":"aut","display":"Delorme, Stefan"},{"family":"Neher","given":"Peter","role":"aut","display":"Neher, Peter"},{"display":"Wennmann, Markus","role":"aut","given":"Markus","family":"Wennmann"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"recId":"331018667","disp":"Advanced automated model for robust bone marrow segmentation in whole-body MRIAcademic radiology","origin":[{"publisher":"Elsevier ; Assoc. of University Radiologists","dateIssuedKey":"1994","publisherPlace":"Philadelphia, PA [u.a.] ; Oak Brook, Ill.","dateIssuedDisp":"1994-"}],"pubHistory":["1.1994 -"],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 18.04.17"],"id":{"zdb":["2050425-1"],"issn":["1878-4046"],"eki":["331018667"]},"title":[{"subtitle":"official journal of the Association of University Radiologists, the Society of Chairs of Academic Radiology Departments, the Association of Program Directors in Radiology, the American Alliance of Academic Chief Residents in Radiology, the Alliance of Medical Student Educators in Radiology, the Radiology Research Alliance, the Radiology Alliance for Health Services Research, and the Medical Image Computing and Computer-Assisted Intervention Society","title_sort":"Academic radiology","title":"Academic radiology"}],"part":{"volume":"32","year":"2025","extent":"12","text":"32(2025), 5, Seite 2824-2835","issue":"5","pages":"2824-2835"}}],"origin":[{"dateIssuedDisp":"May 2025","dateIssuedKey":"2025"}],"physDesc":[{"noteIll":"Illustrationen","extent":"12 S."}],"recId":"194016835X"} | ||
| SRT | |a BAUERFABIAADVANCEDAU2025 | ||