Clinical impact of MRI-guided intracavitary-interstitial brachytherapy in the curative management of advanced-stage cervical cancer
This study investigates the clinical efficacy of MRI-based adaptive brachytherapy (IGABT) using combined intracavitary and interstitial techniques in the curative treatment of patients with advanced cervical cancer (LACC). A retrospective analysis was conducted on 149 LACC patients treated at a sing...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2025
|
| In: |
Current oncology
Year: 2025, Jahrgang: 32, Heft: 3, Pages: 1-18 |
| ISSN: | 1718-7729 |
| DOI: | 10.3390/curroncol32030136 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/curroncol32030136 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1718-7729/32/3/136 
|
| Verfasserangaben: | Antje Wark, Laura Hüfner, Eva Meixner, Jan Oelmann, Laila König, Simon Höne, Katja Lindel, Jürgen Debus and Nathalie Arians |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1940307376 | ||
| 003 | DE-627 | ||
| 005 | 20251105101323.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251105s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/curroncol32030136 |2 doi | |
| 035 | |a (DE-627)1940307376 | ||
| 035 | |a (DE-599)KXP1940307376 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wark, Antje |d 1992- |e VerfasserIn |0 (DE-588)1207281433 |0 (DE-627)1693473801 |4 aut | |
| 245 | 1 | 0 | |a Clinical impact of MRI-guided intracavitary-interstitial brachytherapy in the curative management of advanced-stage cervical cancer |c Antje Wark, Laura Hüfner, Eva Meixner, Jan Oelmann, Laila König, Simon Höne, Katja Lindel, Jürgen Debus and Nathalie Arians |
| 264 | 1 | |c 2025 | |
| 300 | |b Diagramme | ||
| 300 | |a 18 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 26. Februar 2025 | ||
| 500 | |a Gesehen am 05.11.2025 | ||
| 520 | |a This study investigates the clinical efficacy of MRI-based adaptive brachytherapy (IGABT) using combined intracavitary and interstitial techniques in the curative treatment of patients with advanced cervical cancer (LACC). A retrospective analysis was conducted on 149 LACC patients treated at a single center. The therapeutic protocol included intensity-modulated external beam radiotherapy (IMRT) and IGABT. Dosimetric parameters were evaluated for relevance for local control (LC), progression-free survival (PFS), and overall survival (OS) using Kaplan-Meier estimation, Cox regression, and log-rank test. Patients predominantly presented with stage III/IV tumors (81%, FIGO 2018). The median high-risk clinical target volume (hrCTV) was 34 cm3, with a median D90% dose of 88.9 GyEQD2. At 24 months, OS, PFS, and LC rates were 86%, 57%, and 81%, respectively. FIGO stage, tumor volume, and histology were significant predictors of PFS. Higher total hrCTV doses were strongly correlated with improved LC and PFS, emphasizing the importance of precise dosimetric optimization in IGABT and confirming the critical role of IGABT in achieving very good LC rates for LACC. The reported LC rates are comparable to landmark studies, such as INTERLACE and KEYNOTE-A18. This study validates the effectiveness of MRI-guided IGABT in enhancing local tumor control in advanced-stage cervical cancer while providing insights into the prognostic implications of dosimetric parameters such as hrCTV and point A. Future research should address the persistent challenge of distant metastases by exploring the integration of novel systemic treatment options. | ||
| 650 | 4 | |a advanced cervical cancer | |
| 650 | 4 | |a image-guided adaptive brachytherapy | |
| 650 | 4 | |a MRI-guidance | |
| 700 | 1 | |a Hüfner, Laura |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meixner, Eva |e VerfasserIn |0 (DE-588)1222706334 |0 (DE-627)174193141X |4 aut | |
| 700 | 1 | |a Oelmann, Jan |e VerfasserIn |4 aut | |
| 700 | 1 | |a König, Laila |d 1986- |e VerfasserIn |0 (DE-588)1053640579 |0 (DE-627)790403315 |0 (DE-576)409584282 |4 aut | |
| 700 | 1 | |a Höne, Simon |e VerfasserIn |0 (DE-588)1140810049 |0 (DE-627)898708095 |0 (DE-576)494067411 |4 aut | |
| 700 | 1 | |a Lindel, Katja |d 1972- |e VerfasserIn |0 (DE-588)121342689 |0 (DE-627)705399176 |0 (DE-576)292658044 |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
| 700 | 1 | |a Arians, Nathalie |d 1986- |e VerfasserIn |0 (DE-588)1035620782 |0 (DE-627)74879199X |0 (DE-576)383388600 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current oncology |d Toronto, Ontario : Multimed, 2005 |g 32 (2025, 3), 136, Seite [1]-18 |h Online-Ressource |w (DE-627)524623112 |w (DE-600)2270777-3 |w (DE-576)347278280 |x 1718-7729 |7 nnas |a Clinical impact of MRI-guided intracavitary-interstitial brachytherapy in the curative management of advanced-stage cervical cancer |
| 773 | 1 | 8 | |g volume:32 |g year:2025 |g number:3 |g elocationid:136 |g pages:1-18 |g extent:18 |a Clinical impact of MRI-guided intracavitary-interstitial brachytherapy in the curative management of advanced-stage cervical cancer |
| 856 | 4 | 0 | |u https://doi.org/10.3390/curroncol32030136 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/1718-7729/32/3/136 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20251105 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1035620782 |a Arians, Nathalie |m 1035620782:Arians, Nathalie |d 910000 |d 911400 |d 50000 |e 910000PA1035620782 |e 911400PA1035620782 |e 50000PA1035620782 |k 0/910000/ |k 1/910000/911400/ |k 0/50000/ |p 9 |y j | ||
| 998 | |g 1022671421 |a Debus, Jürgen |m 1022671421:Debus, Jürgen |d 910000 |d 911400 |e 910000PD1022671421 |e 911400PD1022671421 |k 0/910000/ |k 1/910000/911400/ |p 8 | ||
| 998 | |g 121342689 |a Lindel, Katja |m 121342689:Lindel, Katja |d 50000 |e 50000PL121342689 |k 0/50000/ |p 7 | ||
| 998 | |g 1140810049 |a Höne, Simon |m 1140810049:Höne, Simon |d 50000 |e 50000PH1140810049 |k 0/50000/ |p 6 | ||
| 998 | |g 1053640579 |a König, Laila |m 1053640579:König, Laila |d 910000 |d 911400 |d 50000 |e 910000PK1053640579 |e 911400PK1053640579 |e 50000PK1053640579 |k 0/910000/ |k 1/910000/911400/ |k 0/50000/ |p 5 | ||
| 998 | |g 1222706334 |a Meixner, Eva |m 1222706334:Meixner, Eva |d 910000 |d 911400 |d 50000 |e 910000PM1222706334 |e 911400PM1222706334 |e 50000PM1222706334 |k 0/910000/ |k 1/910000/911400/ |k 0/50000/ |p 3 | ||
| 998 | |g 1207281433 |a Wark, Antje |m 1207281433:Wark, Antje |d 50000 |e 50000PW1207281433 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1940307376 |e 4796923179 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Antje Wark, Laura Hüfner, Eva Meixner, Jan Oelmann, Laila König, Simon Höne, Katja Lindel, Jürgen Debus and Nathalie Arians"]},"note":["Online veröffentlicht: 26. Februar 2025","Gesehen am 05.11.2025"],"recId":"1940307376","origin":[{"dateIssuedDisp":"2025","dateIssuedKey":"2025"}],"language":["eng"],"id":{"eki":["1940307376"],"doi":["10.3390/curroncol32030136"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Clinical impact of MRI-guided intracavitary-interstitial brachytherapy in the curative management of advanced-stage cervical cancer","title_sort":"Clinical impact of MRI-guided intracavitary-interstitial brachytherapy in the curative management of advanced-stage cervical cancer"}],"person":[{"family":"Wark","display":"Wark, Antje","given":"Antje","role":"aut"},{"role":"aut","given":"Laura","display":"Hüfner, Laura","family":"Hüfner"},{"role":"aut","family":"Meixner","display":"Meixner, Eva","given":"Eva"},{"family":"Oelmann","display":"Oelmann, Jan","given":"Jan","role":"aut"},{"display":"König, Laila","family":"König","given":"Laila","role":"aut"},{"family":"Höne","display":"Höne, Simon","given":"Simon","role":"aut"},{"family":"Lindel","display":"Lindel, Katja","given":"Katja","role":"aut"},{"role":"aut","given":"Jürgen","family":"Debus","display":"Debus, Jürgen"},{"given":"Nathalie","family":"Arians","display":"Arians, Nathalie","role":"aut"}],"physDesc":[{"noteIll":"Diagramme","extent":"18 S."}],"relHost":[{"note":["Gesehen am 21.11.2025","Volltext auch als Teil einer Datenbank verfügbar"],"pubHistory":["Nachgewiesen 12.2005 -"],"recId":"524623112","disp":"Clinical impact of MRI-guided intracavitary-interstitial brachytherapy in the curative management of advanced-stage cervical cancerCurrent oncology","physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Current oncology","title_sort":"Current oncology"}],"part":{"issue":"3","year":"2025","extent":"18","pages":"1-18","text":"32 (2025, 3), 136, Seite [1]-18","volume":"32"},"origin":[{"publisherPlace":"Toronto, Ontario","dateIssuedDisp":"2005-","dateIssuedKey":"2005","publisher":"Multimed"}],"language":["eng"],"id":{"zdb":["2270777-3"],"issn":["1718-7729"],"eki":["524623112"]},"type":{"media":"Online-Ressource","bibl":"periodical"}}]} | ||
| SRT | |a WARKANTJEHCLINICALIM2025 | ||