Immune checkpoint inhibitors-associated vasculitis: a heterogeneous condition with possible severe disease course
Objective To describe presentation, treatment and outcome of immune checkpoint inhibitor (ICI) associated-vasculitis in cancer patients in a multicentre study.Methods Thanks to the ImmunoCancer International Registry (ICIR), a multidisciplinary network focused on the research of the immune related a...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 2025
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| In: |
Rheumatology
Year: 2025, Jahrgang: 64, Heft: 6, Pages: 3685-3690 |
| ISSN: | 1462-0332 |
| DOI: | 10.1093/rheumatology/keae711 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/rheumatology/keae711 Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/rheumatology/article/64/6/3685/7931521 
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| Verfasserangaben: | Noemie Chanson, Alexandre Galvagni, Manuel Ramos-Casals, Juan Ignacio Ruiz, Karijn P. M. Suijkerbuijk, Karolina Gente, Philippe Kerschen, Jean Denis Karam, Rakiba Belkhir, Rodereau Outh, Fabienne Closs-Prophette, Jose Salvador Garcia Morillo, Angel Robles-Marhuenda, Jean-Marie Michot, Anne Laure Voisin, Sabine Messayke, Arianne Laparra, Caroline Robert, Maria Suarez-Almazor, Xavier Mariette, Olivier Lambotte, for the ICIR |
MARC
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| 245 | 1 | 0 | |a Immune checkpoint inhibitors-associated vasculitis |b a heterogeneous condition with possible severe disease course |c Noemie Chanson, Alexandre Galvagni, Manuel Ramos-Casals, Juan Ignacio Ruiz, Karijn P. M. Suijkerbuijk, Karolina Gente, Philippe Kerschen, Jean Denis Karam, Rakiba Belkhir, Rodereau Outh, Fabienne Closs-Prophette, Jose Salvador Garcia Morillo, Angel Robles-Marhuenda, Jean-Marie Michot, Anne Laure Voisin, Sabine Messayke, Arianne Laparra, Caroline Robert, Maria Suarez-Almazor, Xavier Mariette, Olivier Lambotte, for the ICIR |
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| 520 | |a Objective To describe presentation, treatment and outcome of immune checkpoint inhibitor (ICI) associated-vasculitis in cancer patients in a multicentre study.Methods Thanks to the ImmunoCancer International Registry (ICIR), a multidisciplinary network focused on the research of the immune related adverse events related to cancer immunotherapies, patients presenting with a clinical and/or radiological suspicion of vasculitis and histological evidence of vasculitis after being exposed to ICIs were retrospectively identified.Results Twenty-eight cases were identified in the ICIR registry. The median interval between starting ICI treatment and vasculitis diagnosis was 4 months. Small vessel vasculitis was predominant (n = 21), followed by large vessel (n = 4) and medium vessel (n = 3). The small vessel vasculitis included 10 unclassified vasculitis either with limited cutaneous involvement (n = 6) or systemic involvement (n = 4), five IgA vasculitis, three cryoglobulinemic vasculitis, and three ANCA+ vasculitis. At presentation or during the evolution, renal and neurologic manifestations were evidenced in seven cases each (25%). Renal biopsies documented immune glomerulopathies in six cases. Only seven patients (25%) fulfilled the 2022 ACR/EULAR classification criteria (four giant cell arteritis, two EGPA and one GPA). Most patients (90%) required systemic corticosteroid and an additional drug was given in 10 patients (36%). Vasculitis outcome was good: 22 patients had vasculitis complete response, no patient died due to vasculitis. Nine patients (32%) were rechallenged with immunotherapy with only one relapse.Conclusion ICI-associated vasculitis are rare, heterogeneous, but can be severe requiring urgent multidisciplinary management with aggressive treatment. | ||
| 650 | 4 | |a aortitis | |
| 650 | 4 | |a cancer immunotherapy | |
| 650 | 4 | |a glomerulonephritis | |
| 650 | 4 | |a immune checkpoint inhibitor | |
| 650 | 4 | |a immune-related adverse events | |
| 650 | 4 | |a large vessels vasculitis | |
| 650 | 4 | |a purpura | |
| 650 | 4 | |a small vessels vasculitis | |
| 650 | 4 | |a vasculitis | |
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| 700 | 1 | |a Robert, Caroline |e VerfasserIn |0 (DE-588)1128449277 |0 (DE-627)882936972 |0 (DE-576)485924544 |4 aut | |
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