Mapping the coupling between tract reachability and cortical geometry of the human brain

The study of cortical geometry and connectivity is prevalent in human brain research. However, these two aspects of brain structure are usually examined separately, leaving the essential connections between the brain’s folding patterns and white matter connectivity unexplored. In this study, we aim...

Full description

Saved in:
Bibliographic Details
Main Authors: Li, Deying (Author) , Zalesky, Andrew (Author) , Wang, Yufan (Author) , Wang, Haiyan (Author) , Ma, Liang (Author) , Cheng, Luqi (Author) , Banaschewski, Tobias (Author) , Barker, Gareth J. (Author) , Bokde, Arun L. W. (Author) , Brühl, Rüdiger (Author) , Desrivières, Sylvane (Author) , Flor, Herta (Author) , Garavan, Hugh (Author) , Gowland, Penny (Author) , Grigis, Antoine (Author) , Heinz, Andreas (Author) , Lemaître, Hervé (Author) , Martinot, Jean-Luc (Author) , Martinot, Marie-Laure Paillère (Author) , Artiges, Eric (Author) , Nees, Frauke (Author) , Orfanos, Dimitri Papadopoulos (Author) , Poustka, Luise (Author) , Smolka, Michael (Author) , Vaidya, Nilakshi (Author) , Walter, Henrik (Author) , Whelan, Robert (Author) , Schumann, Gunter (Author) , Jia, Tianye (Author) , Chu, Congying (Author) , Fan, Lingzhong (Author)
Format: Article (Journal)
Language:English
Published: 12 August 2025
In: Nature Communications
Year: 2025, Volume: 16, Pages: 1-18
ISSN:2041-1723
DOI:10.1038/s41467-025-62812-9
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-62812-9
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-62812-9
Get full text
Author Notes:Deying Li, Andrew Zalesky, Yufan Wang, Haiyan Wang, Liang Ma, Luqi Cheng, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Rüdiger Brühl, Sylvane Desrivières, Herta Flor, Hugh Garavan, Penny Gowland, Antoine Grigis, Andreas Heinz, Hervé Lemaître, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Tianye Jia, Congying Chu, Lingzhong Fan & IMAGEN Consortium

MARC

LEADER 00000naa a2200000 c 4500
001 1940473365
003 DE-627
005 20251106094146.0
007 cr uuu---uuuuu
008 251106s2025 xx |||||o 00| ||eng c
024 7 |a 10.1038/s41467-025-62812-9  |2 doi 
035 |a (DE-627)1940473365 
035 |a (DE-599)KXP1940473365 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Li, Deying  |e VerfasserIn  |0 (DE-588)1380909295  |0 (DE-627)1940474302  |4 aut 
245 1 0 |a Mapping the coupling between tract reachability and cortical geometry of the human brain  |c Deying Li, Andrew Zalesky, Yufan Wang, Haiyan Wang, Liang Ma, Luqi Cheng, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Rüdiger Brühl, Sylvane Desrivières, Herta Flor, Hugh Garavan, Penny Gowland, Antoine Grigis, Andreas Heinz, Hervé Lemaître, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Tianye Jia, Congying Chu, Lingzhong Fan & IMAGEN Consortium 
264 1 |c 12 August 2025 
300 |b Illustrationen, Diagramme 
300 |a 18 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 06.11.2025 
500 |a Mitglieder des IMAGEN Consortium: Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Rüdiger Brühl, Sylvane Desrivières, Herta Flor, Hugh Garavan, Penny Gowland, Antoine Grigis, Andreas Heinz, Hervé Lemaître, Jean-Luc Martinot, Marie-Laure Paillère Martinot Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann & Tianye Jia 
520 |a The study of cortical geometry and connectivity is prevalent in human brain research. However, these two aspects of brain structure are usually examined separately, leaving the essential connections between the brain’s folding patterns and white matter connectivity unexplored. In this study, we aim to elucidate the fundamental links between cortical geometry and white matter tract connectivity. We develop the concept of tract-geometry coupling (TGC) by optimizing the alignment between tract connectivity to the cortex and multiscale cortical geometry. We confirm in two independent datasets that cortical geometry reliably characterizes tract reachability, and that TGC demonstrates high test-retest reliability and individual-specificity. Interestingly, low-frequency TGC is more heritable and behaviorally informative. Finally, we find that TGC can reproduce task-evoked cortical activation patterns and exhibits non-uniform maturation during youth. Collectively, our study provides an approach to mapping cortical geometry-connectivity coupling, highlighting how these two aspects jointly shape the connected brain. 
650 4 |a Neuroscience 
650 4 |a Systems biology 
700 1 |a Zalesky, Andrew  |e VerfasserIn  |4 aut 
700 1 |a Wang, Yufan  |e VerfasserIn  |4 aut 
700 1 |a Wang, Haiyan  |e VerfasserIn  |4 aut 
700 1 |a Ma, Liang  |e VerfasserIn  |4 aut 
700 1 |a Cheng, Luqi  |e VerfasserIn  |4 aut 
700 1 |a Banaschewski, Tobias  |d 1961-  |e VerfasserIn  |0 (DE-588)115856110  |0 (DE-627)507227301  |0 (DE-576)178364703  |4 aut 
700 1 |a Barker, Gareth J.  |e VerfasserIn  |4 aut 
700 1 |a Bokde, Arun L. W.  |e VerfasserIn  |4 aut 
700 1 |a Brühl, Rüdiger  |e VerfasserIn  |4 aut 
700 1 |a Desrivières, Sylvane  |e VerfasserIn  |4 aut 
700 1 |a Flor, Herta  |d 1954-  |e VerfasserIn  |0 (DE-588)110841816  |0 (DE-627)636273695  |0 (DE-576)160967732  |4 aut 
700 1 |a Garavan, Hugh  |e VerfasserIn  |4 aut 
700 1 |a Gowland, Penny  |e VerfasserIn  |4 aut 
700 1 |a Grigis, Antoine  |e VerfasserIn  |4 aut 
700 1 |a Heinz, Andreas  |e VerfasserIn  |4 aut 
700 1 |a Lemaître, Hervé  |e VerfasserIn  |4 aut 
700 1 |a Martinot, Jean-Luc  |e VerfasserIn  |4 aut 
700 1 |a Martinot, Marie-Laure Paillère  |e VerfasserIn  |4 aut 
700 1 |a Artiges, Eric  |e VerfasserIn  |4 aut 
700 1 |a Nees, Frauke  |e VerfasserIn  |0 (DE-588)140286527  |0 (DE-627)703627244  |0 (DE-576)325389764  |4 aut 
700 1 |a Orfanos, Dimitri Papadopoulos  |e VerfasserIn  |4 aut 
700 1 |a Poustka, Luise  |e VerfasserIn  |0 (DE-588)1032378239  |0 (DE-627)738388688  |0 (DE-576)380005190  |4 aut 
700 1 |a Smolka, Michael  |e VerfasserIn  |0 (DE-588)1073229319  |0 (DE-627)828684685  |0 (DE-576)43475286X  |4 aut 
700 1 |a Vaidya, Nilakshi  |e VerfasserIn  |4 aut 
700 1 |a Walter, Henrik  |e VerfasserIn  |4 aut 
700 1 |a Whelan, Robert  |e VerfasserIn  |4 aut 
700 1 |a Schumann, Gunter  |e VerfasserIn  |4 aut 
700 1 |a Jia, Tianye  |e VerfasserIn  |4 aut 
700 1 |a Chu, Congying  |e VerfasserIn  |4 aut 
700 1 |a Fan, Lingzhong  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Nature Communications  |d [London] : Springer Nature, 2010  |g 16(2025), Artikel-ID 7489, Seite 1-18  |h Online-Ressource  |w (DE-627)626457688  |w (DE-600)2553671-0  |w (DE-576)331555905  |x 2041-1723  |7 nnas  |a Mapping the coupling between tract reachability and cortical geometry of the human brain 
773 1 8 |g volume:16  |g year:2025  |g elocationid:7489  |g pages:1-18  |g extent:18  |a Mapping the coupling between tract reachability and cortical geometry of the human brain 
856 4 0 |u https://doi.org/10.1038/s41467-025-62812-9  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.nature.com/articles/s41467-025-62812-9  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20251106 
993 |a Article 
994 |a 2025 
998 |g 1032378239  |a Poustka, Luise  |m 1032378239:Poustka, Luise  |d 910000  |d 910600  |e 910000PP1032378239  |e 910600PP1032378239  |k 0/910000/  |k 1/910000/910600/  |p 23 
998 |g 110841816  |a Flor, Herta  |m 110841816:Flor, Herta  |d 60000  |e 60000PF110841816  |k 0/60000/  |p 12 
998 |g 115856110  |a Banaschewski, Tobias  |m 115856110:Banaschewski, Tobias  |d 60000  |e 60000PB115856110  |k 0/60000/  |p 7 
999 |a KXP-PPN1940473365  |e 4797530421 
BIB |a Y 
SER |a journal 
JSO |a {"recId":"1940473365","person":[{"given":"Deying","display":"Li, Deying","family":"Li","role":"aut"},{"display":"Zalesky, Andrew","given":"Andrew","family":"Zalesky","role":"aut"},{"display":"Wang, Yufan","given":"Yufan","role":"aut","family":"Wang"},{"display":"Wang, Haiyan","given":"Haiyan","family":"Wang","role":"aut"},{"given":"Liang","display":"Ma, Liang","family":"Ma","role":"aut"},{"role":"aut","family":"Cheng","given":"Luqi","display":"Cheng, Luqi"},{"given":"Tobias","display":"Banaschewski, Tobias","role":"aut","family":"Banaschewski"},{"role":"aut","family":"Barker","display":"Barker, Gareth J.","given":"Gareth J."},{"family":"Bokde","role":"aut","given":"Arun L. W.","display":"Bokde, Arun L. W."},{"display":"Brühl, Rüdiger","given":"Rüdiger","role":"aut","family":"Brühl"},{"role":"aut","family":"Desrivières","given":"Sylvane","display":"Desrivières, Sylvane"},{"family":"Flor","role":"aut","display":"Flor, Herta","given":"Herta"},{"role":"aut","family":"Garavan","given":"Hugh","display":"Garavan, Hugh"},{"given":"Penny","display":"Gowland, Penny","family":"Gowland","role":"aut"},{"given":"Antoine","display":"Grigis, Antoine","family":"Grigis","role":"aut"},{"role":"aut","family":"Heinz","display":"Heinz, Andreas","given":"Andreas"},{"role":"aut","family":"Lemaître","given":"Hervé","display":"Lemaître, Hervé"},{"family":"Martinot","role":"aut","given":"Jean-Luc","display":"Martinot, Jean-Luc"},{"display":"Martinot, Marie-Laure Paillère","given":"Marie-Laure Paillère","role":"aut","family":"Martinot"},{"family":"Artiges","role":"aut","given":"Eric","display":"Artiges, Eric"},{"family":"Nees","role":"aut","display":"Nees, Frauke","given":"Frauke"},{"given":"Dimitri Papadopoulos","display":"Orfanos, Dimitri Papadopoulos","role":"aut","family":"Orfanos"},{"display":"Poustka, Luise","given":"Luise","role":"aut","family":"Poustka"},{"family":"Smolka","role":"aut","display":"Smolka, Michael","given":"Michael"},{"family":"Vaidya","role":"aut","given":"Nilakshi","display":"Vaidya, Nilakshi"},{"given":"Henrik","display":"Walter, Henrik","role":"aut","family":"Walter"},{"role":"aut","family":"Whelan","given":"Robert","display":"Whelan, Robert"},{"family":"Schumann","role":"aut","given":"Gunter","display":"Schumann, Gunter"},{"role":"aut","family":"Jia","given":"Tianye","display":"Jia, Tianye"},{"display":"Chu, Congying","given":"Congying","family":"Chu","role":"aut"},{"display":"Fan, Lingzhong","given":"Lingzhong","role":"aut","family":"Fan"}],"note":["Gesehen am 06.11.2025","Mitglieder des IMAGEN Consortium: Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Rüdiger Brühl, Sylvane Desrivières, Herta Flor, Hugh Garavan, Penny Gowland, Antoine Grigis, Andreas Heinz, Hervé Lemaître, Jean-Luc Martinot, Marie-Laure Paillère Martinot Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann & Tianye Jia"],"language":["eng"],"name":{"displayForm":["Deying Li, Andrew Zalesky, Yufan Wang, Haiyan Wang, Liang Ma, Luqi Cheng, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Rüdiger Brühl, Sylvane Desrivières, Herta Flor, Hugh Garavan, Penny Gowland, Antoine Grigis, Andreas Heinz, Hervé Lemaître, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Tianye Jia, Congying Chu, Lingzhong Fan & IMAGEN Consortium"]},"relHost":[{"recId":"626457688","id":{"zdb":["2553671-0"],"eki":["626457688"],"issn":["2041-1723"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Nature Communications","title_sort":"Nature Communications"}],"origin":[{"publisherPlace":"[London] ; [London]","dateIssuedDisp":"[2010]-","publisher":"Springer Nature ; Nature Publishing Group UK"}],"part":{"text":"16(2025), Artikel-ID 7489, Seite 1-18","pages":"1-18","extent":"18","volume":"16","year":"2025"},"language":["eng"],"pubHistory":["2010-"],"note":["Gesehen am 13.06.24"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Mapping the coupling between tract reachability and cortical geometry of the human brainNature Communications"}],"origin":[{"dateIssuedDisp":"12 August 2025","dateIssuedKey":"2025"}],"title":[{"title":"Mapping the coupling between tract reachability and cortical geometry of the human brain","title_sort":"Mapping the coupling between tract reachability and cortical geometry of the human brain"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"18 S.","noteIll":"Illustrationen, Diagramme"}],"id":{"eki":["1940473365"],"doi":["10.1038/s41467-025-62812-9"]}} 
SRT |a LIDEYINGZAMAPPINGTHE1220