The case for homebrew AI in diagnostic pathology
Artificial intelligence (AI) methods for digital pathology have tremendous potential to improve cancer diagnostics, biomarkers, and ultimately patient care. These AI methods, if marketed and sold, require authorisation or clearance as in vitro diagnostic (IVD) devices by regulatory bodies like the F...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 2025
|
| In: |
The journal of pathology
Year: 2025, Volume: 266, Issue: 4-5, Pages: 390-394 |
| ISSN: | 1096-9896 |
| DOI: | 10.1002/path.6438 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/path.6438 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/path.6438 
|
| Author Notes: | Julien Calderaro, Helen Morement, Frédérique Penault-Llorca, Stephen Gilbert and Jakob Nikolas Kather |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1940474027 | ||
| 003 | DE-627 | ||
| 005 | 20251106093727.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251106s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/path.6438 |2 doi | |
| 035 | |a (DE-627)1940474027 | ||
| 035 | |a (DE-599)KXP1940474027 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Caldéraro, Julien |e VerfasserIn |0 (DE-588)1284310868 |0 (DE-627)1840004827 |4 aut | |
| 245 | 1 | 4 | |a The case for homebrew AI in diagnostic pathology |c Julien Calderaro, Helen Morement, Frédérique Penault-Llorca, Stephen Gilbert and Jakob Nikolas Kather |
| 264 | 1 | |c August 2025 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Zuerst veröffentlicht: 04. Juli 2025 | ||
| 500 | |a Gesehen am 06.11.2025 | ||
| 520 | |a Artificial intelligence (AI) methods for digital pathology have tremendous potential to improve cancer diagnostics, biomarkers, and ultimately patient care. These AI methods, if marketed and sold, require authorisation or clearance as in vitro diagnostic (IVD) devices by regulatory bodies like the Food and Drug Administration (FDA) in the USA or Notified Bodies in the European Union (EU). Many AI tools for digital pathology are unlikely to be commercially viable and taken up by commercial entities ready to navigate these complex and costly processes. However, a longstanding quality framework already exists that allows for lab-developed tests, colloquially known as ‘homebrew’ tests, that are locally validated and performed under the responsibility and oversight of the pathologist. Here we argue for advancing homebrew AI systems within this existing framework to enhance patients' access to supportive digital diagnostic tools. We outline how homebrew AI models are currently permitted under regulatory provisions in the USA and the European Union, how a new US FDA rule may effectively regulate them out of existence, and propose steps to facilitate the safe and effective integration of homebrew AI models in pathology practice. © 2025 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. | ||
| 650 | 4 | |a artificial intelligence | |
| 650 | 4 | |a deep learning | |
| 650 | 4 | |a homebrew | |
| 650 | 4 | |a laboratory-derived test | |
| 650 | 4 | |a pathology | |
| 650 | 4 | |a whole-slide image | |
| 700 | 1 | |a Morement, Helen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Penault-Llorca, Frédérique |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gilbert, Stephen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kather, Jakob Nikolas |d 1989- |e VerfasserIn |0 (DE-588)1064064914 |0 (DE-627)812897587 |0 (DE-576)423589091 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of pathology |d Bognor Regis [u.a.] : Wiley, 1892 |g 266(2025), 4-5 vom: Aug., Seite 390-394 |h Online-Ressource |w (DE-627)269536957 |w (DE-600)1475280-3 |w (DE-576)078590132 |x 1096-9896 |7 nnas |a The case for homebrew AI in diagnostic pathology |
| 773 | 1 | 8 | |g volume:266 |g year:2025 |g number:4-5 |g month:08 |g pages:390-394 |g extent:5 |a The case for homebrew AI in diagnostic pathology |
| 856 | 4 | 0 | |u https://doi.org/10.1002/path.6438 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/path.6438 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20251106 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1064064914 |a Kather, Jakob Nikolas |m 1064064914:Kather, Jakob Nikolas |d 910000 |d 910100 |e 910000PK1064064914 |e 910100PK1064064914 |k 0/910000/ |k 1/910000/910100/ |p 5 |y j | ||
| 999 | |a KXP-PPN1940474027 |e 4797531703 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title":"The case for homebrew AI in diagnostic pathology","title_sort":"case for homebrew AI in diagnostic pathology"}],"note":["Zuerst veröffentlicht: 04. Juli 2025","Gesehen am 06.11.2025"],"origin":[{"dateIssuedDisp":"August 2025","dateIssuedKey":"2025"}],"id":{"eki":["1940474027"],"doi":["10.1002/path.6438"]},"physDesc":[{"extent":"5 S."}],"name":{"displayForm":["Julien Calderaro, Helen Morement, Frédérique Penault-Llorca, Stephen Gilbert and Jakob Nikolas Kather"]},"relHost":[{"recId":"269536957","physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1096-9896"],"zdb":["1475280-3"],"doi":["10.1002/(ISSN)1096-9896"],"eki":["269536957"]},"origin":[{"dateIssuedDisp":"1892-","dateIssuedKey":"1892","publisher":"Wiley","publisherPlace":"Bognor Regis [u.a.]"}],"note":["Gesehen am 28.02.08"],"pubHistory":["1.1892 -"],"title":[{"subtitle":"an official journal of the Pathological Society of Great Britain and Ireland","title_sort":"journal of pathology","title":"The journal of pathology"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"The case for homebrew AI in diagnostic pathologyThe journal of pathology","language":["eng"],"part":{"year":"2025","pages":"390-394","issue":"4-5","text":"266(2025), 4-5 vom: Aug., Seite 390-394","extent":"5","volume":"266"},"corporate":[{"display":"Pathological Society of Great Britain and Ireland","role":"isb"}]}],"recId":"1940474027","person":[{"display":"Caldéraro, Julien","family":"Caldéraro","role":"aut","given":"Julien"},{"display":"Morement, Helen","family":"Morement","role":"aut","given":"Helen"},{"display":"Penault-Llorca, Frédérique","family":"Penault-Llorca","role":"aut","given":"Frédérique"},{"display":"Gilbert, Stephen","family":"Gilbert","role":"aut","given":"Stephen"},{"display":"Kather, Jakob Nikolas","family":"Kather","role":"aut","given":"Jakob Nikolas"}],"language":["eng"]} | ||
| SRT | |a CALDERAROJCASEFORHOM2025 | ||