Buchumschlag

Nitric oxide synthase in cardiac nerve fibers and neurons of rat and guinea pig heart.

Participation of nitric oxide (NO) in the autonomic innervation of rat and guinea pig hearts was investigated by applying the NADPH diaphorase technique and immunohistochemistry with NO synthase antiserum. We present evidence that NO synthase is localized in cardiac ganglion cells and nerve fibers i...

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Hauptverfasser: Klimaschewski, Lars Peter (VerfasserIn) , Kummer, Wolfgang (VerfasserIn) , Mayer, Bernd (VerfasserIn) , Couraud, Jean Yves (VerfasserIn) , Preissler, Ulrike (VerfasserIn) , Philippin, Bärbel (VerfasserIn) , Heym, Christine (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: December 1, 1992
In: Circulation research
Year: 1992, Jahrgang: 71, Heft: 6, Pages: 1533-1537
ISSN:1524-4571
DOI:10.1161/01.RES.71.6.1533
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1161/01.RES.71.6.1533
Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/01.RES.71.6.1533
Volltext
Verfasserangaben:Lars Klimaschewski, Wolfgang Kummer, Bernd Mayer, Jean Yves Couraud, Ulrike Preissler, Bärbel Philippin, and Christine Heym
Beschreibung
Zusammenfassung:Participation of nitric oxide (NO) in the autonomic innervation of rat and guinea pig hearts was investigated by applying the NADPH diaphorase technique and immunohistochemistry with NO synthase antiserum. We present evidence that NO synthase is localized in cardiac ganglion cells and nerve fibers innervating the sinuatrial and atrioventricular nodes, the myocardium, local neurons, coronary arteries, and pulmonary vessels, suggesting an involvement of NO in neurogenic heart rate regulation, myocardial cell function, neuronal transmission in cardiac ganglia, and coronary as well as pulmonary vasodilation.
Beschreibung:Gesehen am 10.11.2025
Beschreibung:Online Resource
ISSN:1524-4571
DOI:10.1161/01.RES.71.6.1533

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