Atlas of gray matter volume differences across psychiatric conditions: a systematic review with a novel meta-analysis that considers co-occurring disorders : archival report
Background - Regional gray matter volume (GMV) differences between individuals with mental disorders and comparison participants may be confounded by co-occurring disorders. To disentangle disorder-specific GMV correlates, we conducted a large-scale multidisorder meta-analysis using a novel approach...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 1, 2025
|
| In: |
Biological psychiatry
Year: 2025, Volume: 98, Issue: 1, Pages: 76-90 |
| ISSN: | 1873-2402 |
| DOI: | 10.1016/j.biopsych.2024.10.020 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.biopsych.2024.10.020 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0006322324017293 
|
| Author Notes: | Lydia Fortea, Maria Ortuño, Michele De Prisco, Vincenzo Oliva, Anton Albajes-Eizagirre, Adriana Fortea, Santiago Madero, Aleix Solanes, Enric Vilajosana, Yuanwei Yao, Lorenzo Del Fabro, Eduard Solé, Norma Verdolini, Alvar Farré-Colomés, Maria Serra-Blasco, Maria Picó-Pérez, Steve Lukito, Toby Wise, Christina Carlisi, Danilo Arnone, Matthew J. Kempton, Alexander Omar Hauson, Scott Wollman, Carles Soriano-Mas, Katya Rubia, Luke Norman, Paolo Fusar-Poli, David Mataix-Cols, Marc Valentí, Esther Via, Narcis Cardoner, Marco Solmi, Jintao Zhang, Pinglei Pan, Jae Il Shin, Miquel A. Fullana, Eduard Vieta, and Joaquim Radua |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1940813344 | ||
| 003 | DE-627 | ||
| 005 | 20251111111537.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251111s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.biopsych.2024.10.020 |2 doi | |
| 035 | |a (DE-627)1940813344 | ||
| 035 | |a (DE-599)KXP1940813344 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Fortea, Lydia |e VerfasserIn |0 (DE-588)1381295355 |0 (DE-627)1940852625 |4 aut | |
| 245 | 1 | 0 | |a Atlas of gray matter volume differences across psychiatric conditions |b a systematic review with a novel meta-analysis that considers co-occurring disorders : archival report |c Lydia Fortea, Maria Ortuño, Michele De Prisco, Vincenzo Oliva, Anton Albajes-Eizagirre, Adriana Fortea, Santiago Madero, Aleix Solanes, Enric Vilajosana, Yuanwei Yao, Lorenzo Del Fabro, Eduard Solé, Norma Verdolini, Alvar Farré-Colomés, Maria Serra-Blasco, Maria Picó-Pérez, Steve Lukito, Toby Wise, Christina Carlisi, Danilo Arnone, Matthew J. Kempton, Alexander Omar Hauson, Scott Wollman, Carles Soriano-Mas, Katya Rubia, Luke Norman, Paolo Fusar-Poli, David Mataix-Cols, Marc Valentí, Esther Via, Narcis Cardoner, Marco Solmi, Jintao Zhang, Pinglei Pan, Jae Il Shin, Miquel A. Fullana, Eduard Vieta, and Joaquim Radua |
| 264 | 1 | |c July 1, 2025 | |
| 300 | |b Illustrationen, Diagramme | ||
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 2. November 2024, Artikelversion: 11. Juni 2025 | ||
| 500 | |a Gesehen am 11.11.2025 | ||
| 520 | |a Background - Regional gray matter volume (GMV) differences between individuals with mental disorders and comparison participants may be confounded by co-occurring disorders. To disentangle disorder-specific GMV correlates, we conducted a large-scale multidisorder meta-analysis using a novel approach that explicitly models co-occurring disorders. - Methods - We systematically reviewed voxel-based morphometry studies indexed in PubMed and Scopus up to January 2023 that compared adults with major mental disorders (anorexia nervosa, schizophrenia spectrum, anxiety, bipolar, major depressive, obsessive-compulsive, and posttraumatic stress disorders plus attention-deficit/hyperactivity, autism spectrum, and borderline personality disorders) with comparison participants. Two authors independently extracted data and assessed quality using the Newcastle-Ottawa Scale. We derived GMV correlates for each disorder using: 1) a multidisorder meta-analysis that accounted for all co-occurring mental disorders simultaneously and 2) separate standard meta-analyses for each disorder in which co-occurring disorders were ignored. We assessed the alterations’ extent, intensity (effect size), and specificity (interdisorder correlations and transdiagnostic alterations) for both approaches. - Results - We included 433 studies (499 datasets) involving 19,718 patients and 16,441 comparison participants (51% female, ages 20-67 years). We provide GMV correlate maps for each disorder using both approaches. The novel approach, which accounted for co-occurring disorders, produced GMV correlates that were more focal and disorder specific (less correlated across disorders and fewer transdiagnostic abnormalities). - Conclusions - This work offers the most comprehensive atlas of GMV correlates across major mental disorders. Modeling co-occurring disorders yielded more specific correlates, supporting this approach’s validity. The atlas NIfTI maps are available online. | ||
| 650 | 4 | |a Anxiety disorders | |
| 650 | 4 | |a Comorbidity | |
| 650 | 4 | |a Gray matter volume | |
| 650 | 4 | |a Major depressive disorder | |
| 650 | 4 | |a Meta-analysis | |
| 650 | 4 | |a Psychiatric conditions | |
| 700 | 1 | |a Ortuño, Maria |e VerfasserIn |4 aut | |
| 700 | 1 | |a De Prisco, Michele |e VerfasserIn |4 aut | |
| 700 | 1 | |a Oliva, Vincenzo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Albajes-Eizagirre, Anton |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fortea, Adriana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Madero, Santiago |e VerfasserIn |4 aut | |
| 700 | 1 | |a Solanes, Aleix |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vilajosana, Enric |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yao, Yuanwei |e VerfasserIn |4 aut | |
| 700 | 1 | |a Del Fabro, Lorenzo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Solé, Eduard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Verdolini, Norma |e VerfasserIn |4 aut | |
| 700 | 1 | |a Farré i Colomés, Àlvar |e VerfasserIn |0 (DE-588)1321257864 |0 (DE-627)188136433X |4 aut | |
| 700 | 1 | |a Serra-Blasco, Maria |e VerfasserIn |4 aut | |
| 700 | 1 | |a Picó-Pérez, Maria |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lukito, Steve |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wise, Toby |e VerfasserIn |4 aut | |
| 700 | 1 | |a Carlisi, Christina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Arnone, Danilo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kempton, Matthew J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hauson, Alexander Omar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wollman, Scott |e VerfasserIn |4 aut | |
| 700 | 1 | |a Soriano-Mas, Carles |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rubia, Katya |e VerfasserIn |4 aut | |
| 700 | 1 | |a Norman, Luke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fusar-Poli, Paolo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mataix-Cols, David |e VerfasserIn |4 aut | |
| 700 | 1 | |a Valentí, Marc |e VerfasserIn |4 aut | |
| 700 | 1 | |a Via, Esther |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cardoner, Narcis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Solmi, Marco |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhang, Jintao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pan, Pinglei |e VerfasserIn |4 aut | |
| 700 | 1 | |a Shin, Jae Il |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fullana, Miquel A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vieta, Eduard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Radua, Joaquim |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biological psychiatry |d Amsterdam [u.a.] : Elsevier Science, 1985 |g 98(2025), 1 vom: Juli, Seite 76-90 |h Online-Ressource |w (DE-627)306654296 |w (DE-600)1499907-9 |w (DE-576)115780807 |x 1873-2402 |7 nnas |a Atlas of gray matter volume differences across psychiatric conditions a systematic review with a novel meta-analysis that considers co-occurring disorders : archival report |
| 773 | 1 | 8 | |g volume:98 |g year:2025 |g number:1 |g month:07 |g pages:76-90 |g extent:15 |a Atlas of gray matter volume differences across psychiatric conditions a systematic review with a novel meta-analysis that considers co-occurring disorders : archival report |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.biopsych.2024.10.020 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0006322324017293 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20251111 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1321257864 |a Farré i Colomés, Àlvar |m 1321257864:Farré i Colomés, Àlvar |d 60000 |e 60000PF1321257864 |k 0/60000/ |p 14 | ||
| 999 | |a KXP-PPN1940813344 |e 480205341X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Online verfügbar: 2. November 2024, Artikelversion: 11. Juni 2025","Gesehen am 11.11.2025"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1940813344","language":["eng"],"person":[{"given":"Lydia","family":"Fortea","role":"aut","display":"Fortea, Lydia","roleDisplay":"VerfasserIn"},{"family":"Ortuño","given":"Maria","roleDisplay":"VerfasserIn","display":"Ortuño, Maria","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"De Prisco, Michele","given":"Michele","family":"De Prisco"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Oliva, Vincenzo","given":"Vincenzo","family":"Oliva"},{"family":"Albajes-Eizagirre","given":"Anton","roleDisplay":"VerfasserIn","display":"Albajes-Eizagirre, Anton","role":"aut"},{"family":"Fortea","given":"Adriana","display":"Fortea, Adriana","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Santiago","family":"Madero","role":"aut","roleDisplay":"VerfasserIn","display":"Madero, Santiago"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Solanes, Aleix","given":"Aleix","family":"Solanes"},{"display":"Vilajosana, Enric","roleDisplay":"VerfasserIn","role":"aut","family":"Vilajosana","given":"Enric"},{"family":"Yao","given":"Yuanwei","roleDisplay":"VerfasserIn","display":"Yao, Yuanwei","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Del Fabro, Lorenzo","role":"aut","family":"Del Fabro","given":"Lorenzo"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Solé, Eduard","given":"Eduard","family":"Solé"},{"display":"Verdolini, Norma","roleDisplay":"VerfasserIn","role":"aut","family":"Verdolini","given":"Norma"},{"display":"Farré i Colomés, Àlvar","roleDisplay":"VerfasserIn","role":"aut","family":"Farré i Colomés","given":"Àlvar"},{"family":"Serra-Blasco","given":"Maria","roleDisplay":"VerfasserIn","display":"Serra-Blasco, Maria","role":"aut"},{"display":"Picó-Pérez, Maria","roleDisplay":"VerfasserIn","role":"aut","family":"Picó-Pérez","given":"Maria"},{"family":"Lukito","given":"Steve","display":"Lukito, Steve","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Wise","given":"Toby","roleDisplay":"VerfasserIn","display":"Wise, Toby","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Carlisi, Christina","role":"aut","family":"Carlisi","given":"Christina"},{"family":"Arnone","given":"Danilo","display":"Arnone, Danilo","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Kempton, Matthew J.","given":"Matthew J.","family":"Kempton"},{"given":"Alexander Omar","family":"Hauson","role":"aut","display":"Hauson, Alexander Omar","roleDisplay":"VerfasserIn"},{"family":"Wollman","given":"Scott","roleDisplay":"VerfasserIn","display":"Wollman, Scott","role":"aut"},{"given":"Carles","family":"Soriano-Mas","role":"aut","roleDisplay":"VerfasserIn","display":"Soriano-Mas, Carles"},{"roleDisplay":"VerfasserIn","display":"Rubia, Katya","role":"aut","family":"Rubia","given":"Katya"},{"display":"Norman, Luke","roleDisplay":"VerfasserIn","role":"aut","family":"Norman","given":"Luke"},{"family":"Fusar-Poli","given":"Paolo","display":"Fusar-Poli, Paolo","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Mataix-Cols, David","roleDisplay":"VerfasserIn","role":"aut","family":"Mataix-Cols","given":"David"},{"family":"Valentí","given":"Marc","display":"Valentí, Marc","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Esther","family":"Via","role":"aut","roleDisplay":"VerfasserIn","display":"Via, Esther"},{"display":"Cardoner, Narcis","roleDisplay":"VerfasserIn","role":"aut","family":"Cardoner","given":"Narcis"},{"family":"Solmi","given":"Marco","display":"Solmi, Marco","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Zhang, Jintao","roleDisplay":"VerfasserIn","role":"aut","family":"Zhang","given":"Jintao"},{"family":"Pan","given":"Pinglei","roleDisplay":"VerfasserIn","display":"Pan, Pinglei","role":"aut"},{"role":"aut","display":"Shin, Jae Il","roleDisplay":"VerfasserIn","given":"Jae Il","family":"Shin"},{"given":"Miquel A.","family":"Fullana","role":"aut","roleDisplay":"VerfasserIn","display":"Fullana, Miquel A."},{"given":"Eduard","family":"Vieta","role":"aut","roleDisplay":"VerfasserIn","display":"Vieta, Eduard"},{"given":"Joaquim","family":"Radua","role":"aut","roleDisplay":"VerfasserIn","display":"Radua, Joaquim"}],"title":[{"title_sort":"Atlas of gray matter volume differences across psychiatric conditions","subtitle":"a systematic review with a novel meta-analysis that considers co-occurring disorders : archival report","title":"Atlas of gray matter volume differences across psychiatric conditions"}],"physDesc":[{"noteIll":"Illustrationen, Diagramme","extent":"15 S."}],"relHost":[{"title":[{"title_sort":"Biological psychiatry","subtitle":"a journal of psychiatric neuroscience ; a publication of the Society of Biological Psychiatry","title":"Biological psychiatry"}],"pubHistory":["Nachgewiesen 20.1985 -"],"part":{"pages":"76-90","issue":"1","year":"2025","extent":"15","text":"98(2025), 1 vom: Juli, Seite 76-90","volume":"98"},"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Atlas of gray matter volume differences across psychiatric conditions a systematic review with a novel meta-analysis that considers co-occurring disorders : archival reportBiological psychiatry","note":["Gesehen am 08.01.20","Ungezählte Beil.: Supplement"],"recId":"306654296","language":["eng"],"origin":[{"dateIssuedKey":"1985","publisher":"Elsevier Science","dateIssuedDisp":"1985-","publisherPlace":"Amsterdam [u.a.]"}],"id":{"zdb":["1499907-9"],"eki":["306654296"],"issn":["1873-2402"]},"physDesc":[{"extent":"Online-Ressource"}]}],"name":{"displayForm":["Lydia Fortea, Maria Ortuño, Michele De Prisco, Vincenzo Oliva, Anton Albajes-Eizagirre, Adriana Fortea, Santiago Madero, Aleix Solanes, Enric Vilajosana, Yuanwei Yao, Lorenzo Del Fabro, Eduard Solé, Norma Verdolini, Alvar Farré-Colomés, Maria Serra-Blasco, Maria Picó-Pérez, Steve Lukito, Toby Wise, Christina Carlisi, Danilo Arnone, Matthew J. Kempton, Alexander Omar Hauson, Scott Wollman, Carles Soriano-Mas, Katya Rubia, Luke Norman, Paolo Fusar-Poli, David Mataix-Cols, Marc Valentí, Esther Via, Narcis Cardoner, Marco Solmi, Jintao Zhang, Pinglei Pan, Jae Il Shin, Miquel A. Fullana, Eduard Vieta, and Joaquim Radua"]},"origin":[{"dateIssuedDisp":"July 1, 2025","dateIssuedKey":"2025"}],"id":{"doi":["10.1016/j.biopsych.2024.10.020"],"eki":["1940813344"]}} | ||
| SRT | |a FORTEALYDIATLASOFGRA1202 | ||