Impact of hypoxic versus oxic conditions on local tumor control after proton irradiation in a rat prostate carcinoma
Background and purpose - Hypoxia in tumors significantly contributes to radiation resistance, often leading to poor treatment outcomes. In vitro studies demonstrated that proton irradiation not only exhibits an increased relative biological effectiveness (RBE), but also a lower oxygen enhancement ra...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 2025
|
| In: |
Clinical and translational radiation oncology
Year: 2025, Jahrgang: 53, Pages: 1-7 |
| ISSN: | 2405-6308 |
| DOI: | 10.1016/j.ctro.2025.100957 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ctro.2025.100957 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2405630825000473 
|
| Verfasserangaben: | Michaela Schmitt, Christin Glowa, Ina Kurth, Peter Peschke, Stephan Brons, Christian P. Karger |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1940861667 | ||
| 003 | DE-627 | ||
| 005 | 20251120193726.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251111s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ctro.2025.100957 |2 doi | |
| 035 | |a (DE-627)1940861667 | ||
| 035 | |a (DE-599)KXP1940861667 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 30 |2 sdnb | ||
| 100 | 1 | |a Schmitt, Michaela |d 1997- |e VerfasserIn |0 (DE-588)1368510981 |0 (DE-627)1928078397 |4 aut | |
| 245 | 1 | 0 | |a Impact of hypoxic versus oxic conditions on local tumor control after proton irradiation in a rat prostate carcinoma |c Michaela Schmitt, Christin Glowa, Ina Kurth, Peter Peschke, Stephan Brons, Christian P. Karger |
| 264 | 1 | |c July 2025 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 12. April 2025, Artikelversion: 17. April 2025 | ||
| 500 | |a Gesehen am 11.11.2025 | ||
| 520 | |a Background and purpose - Hypoxia in tumors significantly contributes to radiation resistance, often leading to poor treatment outcomes. In vitro studies demonstrated that proton irradiation not only exhibits an increased relative biological effectiveness (RBE), but also a lower oxygen enhancement ratio (OER). This study explored the impact of hypoxic and oxic conditions on local tumor control after proton irradiation in a rat prostate carcinoma. - Material and methods - Subcutaneously transplanted Dunning R3327-HI rat prostate carcinomas were irradiated with varying single doses of protons under oxic or hypoxic conditions. Hypoxia was induced by clamping the tumor-supplying vessels. The biological endpoint was local tumor control assessed 300 days after irradiation. Dose-response curves were determined and based on the doses required for 50 % tumor control probability (TCD50), the RBE and OER were calculated. - Results - The TCD50 value was significantly higher under hypoxic than under oxic conditions (73.4 ± 1.9 Gy vs. 50.5 ± 1.6 Gy), resulting in an OER of 1.45 ± 0.06 for proton irradiation. Compared to photon irradiation, the RBE for protons was of 1.23 ± 0.07 under oxic and 1.30 ± 0.04 under hypoxic conditions. - Conclusion - Proton irradiations showed a 5 % reduction in OER compared to the previously measured photon value of 1.53 ± 0.08, suggesting a slightly higher effectiveness of protons in hypoxic tumors as compared to photons. | ||
| 650 | 4 | |a Dose-response curves | |
| 650 | 4 | |a Hypoxia | |
| 650 | 4 | |a Oxygen enhancement ratio | |
| 650 | 4 | |a Proton radiotherapy | |
| 650 | 4 | |a Relative biological effectiveness | |
| 700 | 1 | |a Glowa, Christin |e VerfasserIn |0 (DE-588)1047941457 |0 (DE-627)779617231 |0 (DE-576)401773469 |4 aut | |
| 700 | 1 | |a Kurth, Ina |d 1979- |e VerfasserIn |0 (DE-588)1018535802 |0 (DE-627)690629044 |0 (DE-576)354284207 |4 aut | |
| 700 | 1 | |a Peschke, Peter |e VerfasserIn |0 (DE-588)114228638X |0 (DE-627)1001681452 |0 (DE-576)494783443 |4 aut | |
| 700 | 1 | |a Brons, Stephan |e VerfasserIn |0 (DE-588)1072782375 |0 (DE-627)828233594 |0 (DE-576)434240478 |4 aut | |
| 700 | 1 | |a Karger, Christian |e VerfasserIn |0 (DE-588)1077113641 |0 (DE-627)836027280 |0 (DE-576)170866459 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical and translational radiation oncology |d Amsterdam : Elsevier, 2016 |g 53(2025) vom: Juli, Artikel-ID 100957, Seite 1-7 |h Online-Ressource |w (DE-627)880788097 |w (DE-600)2885426-3 |w (DE-576)483742570 |x 2405-6308 |7 nnas |a Impact of hypoxic versus oxic conditions on local tumor control after proton irradiation in a rat prostate carcinoma |
| 773 | 1 | 8 | |g volume:53 |g year:2025 |g month:07 |g elocationid:100957 |g pages:1-7 |g extent:7 |a Impact of hypoxic versus oxic conditions on local tumor control after proton irradiation in a rat prostate carcinoma |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ctro.2025.100957 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S2405630825000473 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20251111 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1077113641 |a Karger, Christian |m 1077113641:Karger, Christian |d 50000 |e 50000PK1077113641 |k 0/50000/ |p 6 |y j | ||
| 998 | |g 1018535802 |a Kurth, Ina |m 1018535802:Kurth, Ina |d 50000 |e 50000PK1018535802 |k 0/50000/ |p 3 | ||
| 998 | |g 1047941457 |a Glowa, Christin |m 1047941457:Glowa, Christin |d 60000 |d 60200 |d 60210 |e 60000PG1047941457 |e 60200PG1047941457 |e 60210PG1047941457 |k 0/60000/ |k 1/60000/60200/ |k 2/60000/60200/60210/ |p 2 | ||
| 998 | |g 1368510981 |a Schmitt, Michaela |m 1368510981:Schmitt, Michaela |d 140000 |e 140000PS1368510981 |k 0/140000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1940861667 |e 4802127138 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1940861667","id":{"doi":["10.1016/j.ctro.2025.100957"],"eki":["1940861667"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"July 2025"}],"name":{"displayForm":["Michaela Schmitt, Christin Glowa, Ina Kurth, Peter Peschke, Stephan Brons, Christian P. Karger"]},"note":["Online veröffentlicht: 12. April 2025, Artikelversion: 17. April 2025","Gesehen am 11.11.2025"],"language":["eng"],"person":[{"display":"Schmitt, Michaela","family":"Schmitt","role":"aut","given":"Michaela"},{"role":"aut","family":"Glowa","display":"Glowa, Christin","given":"Christin"},{"role":"aut","family":"Kurth","display":"Kurth, Ina","given":"Ina"},{"display":"Peschke, Peter","role":"aut","family":"Peschke","given":"Peter"},{"display":"Brons, Stephan","family":"Brons","role":"aut","given":"Stephan"},{"family":"Karger","role":"aut","display":"Karger, Christian","given":"Christian"}],"relHost":[{"note":["Gesehen am 26.05.2020"],"pubHistory":["Volume 1 (December 2016)-"],"language":["eng"],"id":{"issn":["2405-6308"],"eki":["880788097"],"zdb":["2885426-3"]},"recId":"880788097","type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Impact of hypoxic versus oxic conditions on local tumor control after proton irradiation in a rat prostate carcinomaClinical and translational radiation oncology","origin":[{"publisherPlace":"Amsterdam","dateIssuedDisp":"[2016]-","publisher":"Elsevier"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Clinical and translational radiation oncology","title_sort":"Clinical and translational radiation oncology"}],"part":{"volume":"53","year":"2025","text":"53(2025) vom: Juli, Artikel-ID 100957, Seite 1-7","pages":"1-7","extent":"7"}}],"physDesc":[{"extent":"7 S."}],"title":[{"title_sort":"Impact of hypoxic versus oxic conditions on local tumor control after proton irradiation in a rat prostate carcinoma","title":"Impact of hypoxic versus oxic conditions on local tumor control after proton irradiation in a rat prostate carcinoma"}]} | ||
| SRT | |a SCHMITTMICIMPACTOFHY2025 | ||