Comparing inflammatory biomarkers in cardiovascular disease: insights from the LURIC study
Inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), and interleukin-6 (IL-6), have been associated with an increased risk of future cardiovascular events. While they provide valuable prognostic information, these associations do not necessarily impl...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 July 2025
|
| In: |
International journal of molecular sciences
Year: 2025, Jahrgang: 26, Heft: 15, Pages: 1-15 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms26157335 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms26157335 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/26/15/7335 
|
| Verfasserangaben: | Angela P. Moissl, Graciela E. Delgado, Hubert Scharnagl, Rüdiger Siekmeier, Bernhard K. Krämer, Daniel Duerschmied, Winfried März and Marcus E. Kleber |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 194095584X | ||
| 003 | DE-627 | ||
| 005 | 20251112100345.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251112s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ijms26157335 |2 doi | |
| 035 | |a (DE-627)194095584X | ||
| 035 | |a (DE-599)KXP194095584X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Moissl-Blanke, Angela P. |d 1984- |e VerfasserIn |0 (DE-588)1192773756 |0 (DE-627)1671247248 |4 aut | |
| 245 | 1 | 0 | |a Comparing inflammatory biomarkers in cardiovascular disease |b insights from the LURIC study |c Angela P. Moissl, Graciela E. Delgado, Hubert Scharnagl, Rüdiger Siekmeier, Bernhard K. Krämer, Daniel Duerschmied, Winfried März and Marcus E. Kleber |
| 246 | 1 | |i Titel des übergeordneten Special issue |a The Serum Amyloid A (SAA) family : (patho)physiological functions in (non)mammalian systems | |
| 264 | 1 | |c 29 July 2025 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.11.2025 | ||
| 520 | |a Inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), and interleukin-6 (IL-6), have been associated with an increased risk of future cardiovascular events. While they provide valuable prognostic information, these associations do not necessarily imply a direct causal role. The combined prognostic utility of these markers, however, remains insufficiently studied. We analysed 3300 well-characterised participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study, all of whom underwent coronary angiography. Participants were stratified based on their serum concentrations of hsCRP, SAA, and IL-6. Associations between biomarker combinations and mortality were assessed using multivariate Cox regression and ROC analysis. Individuals with elevated hsCRP and SAA or IL-6 showed higher prevalence rates of coronary artery disease, heart failure, and adverse metabolic traits. These “both high” groups had lower estimated glomerular filtration rate, higher NT-proBNP, and increased HbA1c. Combined elevations of hsCRP and SAA were significantly associated with higher all-cause and cardiovascular mortality in partially adjusted models. However, these associations weakened after adjusting for IL-6. IL-6 alone demonstrated the highest predictive power (AUC: 0.638) and improved risk discrimination when included in multi-marker models. The co-elevation of hsCRP, SAA, and IL-6 identifies a high-risk phenotype characterised by greater cardiometabolic burden and increased mortality. IL-6 may reflect upstream inflammatory activity and could serve as a therapeutic target. Multi-marker inflammatory profiling holds promise for refining cardiovascular risk prediction and advancing personalised prevention strategies. | ||
| 650 | 4 | |a biomarkers | |
| 650 | 4 | |a cardiovascular risk | |
| 650 | 4 | |a high-sensitive C-reactive protein (hsCRP) | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a interleukin-6 | |
| 650 | 4 | |a mortality | |
| 650 | 4 | |a risk stratification | |
| 650 | 4 | |a serum amyloid A | |
| 700 | 1 | |a Delgado Gonzales de Kleber, Graciela |d 1960- |e VerfasserIn |0 (DE-588)1070236403 |0 (DE-627)823400379 |0 (DE-576)429882386 |4 aut | |
| 700 | 1 | |a Scharnagl, Hubert |e VerfasserIn |0 (DE-588)1100175954 |0 (DE-627)859149919 |0 (DE-576)18647525X |4 aut | |
| 700 | 1 | |a Siekmeier, Rüdiger |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krämer, Bernhard |d 1957- |e VerfasserIn |0 (DE-588)14017589X |0 (DE-627)70358927X |0 (DE-576)314926852 |4 aut | |
| 700 | 1 | |a Dürschmied, Daniel |d 1976- |e VerfasserIn |0 (DE-588)129152196 |0 (DE-627)390022462 |0 (DE-576)187844623 |4 aut | |
| 700 | 1 | |a März, Winfried |d 1958- |e VerfasserIn |0 (DE-588)1027603599 |0 (DE-627)729463605 |0 (DE-576)373454635 |4 aut | |
| 700 | 1 | |a Kleber, Marcus E. |d 1974- |e VerfasserIn |0 (DE-588)1030135177 |0 (DE-627)734830440 |0 (DE-576)377941379 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of molecular sciences |d Basel : Molecular Diversity Preservation International, 2000 |g 26(2025), 15, Artikel-ID 7335, Seite 1-15 |h Online-Ressource |w (DE-627)316340715 |w (DE-600)2019364-6 |w (DE-576)281194653 |x 1422-0067 |7 nnas |a Comparing inflammatory biomarkers in cardiovascular disease insights from the LURIC study |
| 773 | 1 | 8 | |g volume:26 |g year:2025 |g number:15 |g elocationid:7335 |g pages:1-15 |g extent:15 |a Comparing inflammatory biomarkers in cardiovascular disease insights from the LURIC study |
| 856 | 4 | 0 | |u https://doi.org/10.3390/ijms26157335 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/1422-0067/26/15/7335 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20251112 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1030135177 |a Kleber, Marcus E. |m 1030135177:Kleber, Marcus E. |d 60000 |d 61400 |e 60000PK1030135177 |e 61400PK1030135177 |k 0/60000/ |k 1/60000/61400/ |p 8 |y j | ||
| 998 | |g 1027603599 |a März, Winfried |m 1027603599:März, Winfried |d 910000 |d 910100 |d 60000 |d 61400 |e 910000PM1027603599 |e 910100PM1027603599 |e 60000PM1027603599 |e 61400PM1027603599 |k 0/910000/ |k 1/910000/910100/ |k 0/60000/ |k 1/60000/61400/ |p 7 | ||
| 998 | |g 129152196 |a Dürschmied, Daniel |m 129152196:Dürschmied, Daniel |d 60000 |d 61000 |e 60000PD129152196 |e 61000PD129152196 |k 0/60000/ |k 1/60000/61000/ |p 6 | ||
| 998 | |g 14017589X |a Krämer, Bernhard |m 14017589X:Krämer, Bernhard |d 60000 |d 61400 |e 60000PK14017589X |e 61400PK14017589X |k 0/60000/ |k 1/60000/61400/ |p 5 | ||
| 998 | |g 1070236403 |a Delgado Gonzales de Kleber, Graciela |m 1070236403:Delgado Gonzales de Kleber, Graciela |p 2 | ||
| 998 | |g 1192773756 |a Moissl-Blanke, Angela P. |m 1192773756:Moissl-Blanke, Angela P. |d 60000 |d 61400 |e 60000PM1192773756 |e 61400PM1192773756 |k 0/60000/ |k 1/60000/61400/ |p 1 |x j | ||
| 999 | |a KXP-PPN194095584X |e 4803424365 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"titleAlt":[{"title":"The Serum Amyloid A (SAA) family : (patho)physiological functions in (non)mammalian systems"}],"person":[{"display":"Moissl-Blanke, Angela P.","family":"Moissl-Blanke","given":"Angela P.","role":"aut"},{"display":"Delgado Gonzales de Kleber, Graciela","family":"Delgado Gonzales de Kleber","role":"aut","given":"Graciela"},{"role":"aut","given":"Hubert","display":"Scharnagl, Hubert","family":"Scharnagl"},{"display":"Siekmeier, Rüdiger","family":"Siekmeier","given":"Rüdiger","role":"aut"},{"given":"Bernhard","role":"aut","display":"Krämer, Bernhard","family":"Krämer"},{"given":"Daniel","role":"aut","family":"Dürschmied","display":"Dürschmied, Daniel"},{"given":"Winfried","role":"aut","family":"März","display":"März, Winfried"},{"family":"Kleber","display":"Kleber, Marcus E.","given":"Marcus E.","role":"aut"}],"relHost":[{"recId":"316340715","physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["316340715"],"zdb":["2019364-6"],"issn":["1422-0067","1661-6596"]},"title":[{"title_sort":"International journal of molecular sciences","title":"International journal of molecular sciences"}],"pubHistory":["1.2000 -"],"note":["Gesehen am 17.09.20"],"origin":[{"publisherPlace":"Basel","publisher":"Molecular Diversity Preservation International","dateIssuedKey":"2000","dateIssuedDisp":"2000-"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Comparing inflammatory biomarkers in cardiovascular disease insights from the LURIC studyInternational journal of molecular sciences","language":["eng"],"part":{"extent":"15","volume":"26","year":"2025","pages":"1-15","issue":"15","text":"26(2025), 15, Artikel-ID 7335, Seite 1-15"},"titleAlt":[{"title":"IJMS"}]}],"recId":"194095584X","physDesc":[{"extent":"15 S."}],"name":{"displayForm":["Angela P. Moissl, Graciela E. Delgado, Hubert Scharnagl, Rüdiger Siekmeier, Bernhard K. Krämer, Daniel Duerschmied, Winfried März and Marcus E. Kleber"]},"id":{"eki":["194095584X"],"doi":["10.3390/ijms26157335"]},"title":[{"title_sort":"Comparing inflammatory biomarkers in cardiovascular disease","subtitle":"insights from the LURIC study","title":"Comparing inflammatory biomarkers in cardiovascular disease"}],"origin":[{"dateIssuedDisp":"29 July 2025","dateIssuedKey":"2025"}],"note":["Gesehen am 12.11.2025"],"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a MOISSLBLANCOMPARINGI2920 | ||