A genome wide search for non-additive allele effects identifies PSKH2 as involved in the variability of Factor V activity

Background Factor V (FV) is a key molecular player in the coagulation cascade. FV plasma levels have been associated with several human diseases, including thrombosis, bleeding and diabetic complications. So far, two genes have been robustly found through genome wide association analyses to contribu...

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Autores principales:	Gendre, Blandine (Autor) , Martinez-Perez, Angel (Autor) , Kleber, Marcus E. (Autor) , Vlieg, Astrid van Hylckama (Autor) , Boland, Anne (Autor) , Olaso, Robert (Autor) , Germain, Marine (Autor) , Munsch, Gaëlle (Autor) , Moissl-Blanke, Angela P. (Autor) , Suchon, Pierre (Autor) , Souto, Juan Carlos (Autor) , Soria, José Manuel (Autor) , Deleuze, Jean-François (Autor) , März, Winfried (Autor) , Rosendaal, Frits R. (Autor) , Sabater-Lleal, Maria (Autor) , Morange, Pierre-Emmanuel (Autor) , Trégouët, David-Alexandre (Autor)
Formato:	Article (Journal) Chapter/Article
Lenguaje:	inglés
Publicado:	February 09, 2024
In:	bioRxiv beta Year: 2024, Pages: 1-23
DOI:	10.1101/2024.02.08.579474
Acceso en línea:	Verlag, kostenfrei, Volltext: https://doi.org/10.1101/2024.02.08.579474 Verlag, kostenfrei, Volltext: https://www.biorxiv.org/content/10.1101/2024.02.08.579474v1
Notas de Autor:	Blandine Gendre, Angel Martinez-Perez, Marcus E. Kleber, Astrid van Hylckama Vlieg, Anne Boland, Robert Olaso, Marine Germain, Gaëlle Munsch, Angela Patricia Moissl, Pierre Suchon, Juan Carlos Souto, José Manuel Soria, CHARGE Hemostasis working Group, Jean-François Deleuze, Winfried März, Frits R. Rosendaal, Maria Sabater-Lleal, Pierre-Emmanuel Morange, David-Alexandre Trégouët

Genome‐wide search for nonadditive allele effects identifies PSKH2 as involved in the variability of factor V activity por Gendre, Blandine (Autor) , Martinez‐Perez, Angel (Autor) , Kleber, Marcus E. (Autor) , van Hylckama Vlieg, Astrid (Autor) , Boland, Anne (Autor) , Olaso, Robert (Autor) , Germain, Marine (Autor) , Munsch, Gaëlle (Autor) , Moissl-Blanke, Angela P. (Autor) , Suchon, Pierre (Autor) , Souto, Juan Carlos (Autor) , Soria, José Manuel (Autor) , Deleuze, Jean‐François (Autor) , März, Winfried (Autor) , Rosendaal, Frits R. (Autor) , Sabater‐Lleal, Maria (Autor) , Morange, Pierre‐Emmanuel (Autor) , Trégouët, David‐Alexandre (Autor) ,

en: Journal of the American Heart Association, 13 (2024), 21, Artikel-ID e034943, Seite 1-9

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A genome wide search for non-additive allele effects identifies PSKH2 as involved in the variability of Factor V activity

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