Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics
Imaging transcriptomics has become a power tool for linking imaging-derived phenotypes (IDPs) to genomic mechanisms. Yet, its potential for guiding CNS drug discovery remains underexplored. Here, utilizing spatially-dense representations of the human brain transcriptome, we present an analytical fra...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
22 July 2025
|
| In: |
Nature Communications
Year: 2025, Jahrgang: 16, Pages: 1-14 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-025-61927-3 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-61927-3 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-61927-3 
|
| Verfasserangaben: | Christine Ecker, Charlotte M. Pretzsch, Johanna Leyhausen, Lisa M. Berg, Caroline Gurr, Hanna Seelemeyer, Grainne McAlonan, Nicolaas A. Puts, Eva Loth, Flavio Dell’Aqua, Luke Mason, Tony Charman, Bethany Oakley, Thomas Bourgeron, Christian Beckmann, Jan K. Buitelaar, Celso Arango, Tobias Banaschewski, Andreas G. Chiocchetti, Christine M. Freitag, Elke Hattingen, Dilja Krueger-Burg, Michael J. Schmeisser, Jonathan Repple, Andreas Reif & Declan G. Murphy |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1941078176 | ||
| 003 | DE-627 | ||
| 005 | 20251113091625.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251113s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-025-61927-3 |2 doi | |
| 035 | |a (DE-627)1941078176 | ||
| 035 | |a (DE-599)KXP1941078176 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 11 |2 sdnb | ||
| 100 | 1 | |a Ecker, Christine |e VerfasserIn |0 (DE-588)1381477542 |0 (DE-627)1941078877 |4 aut | |
| 245 | 1 | 0 | |a Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics |c Christine Ecker, Charlotte M. Pretzsch, Johanna Leyhausen, Lisa M. Berg, Caroline Gurr, Hanna Seelemeyer, Grainne McAlonan, Nicolaas A. Puts, Eva Loth, Flavio Dell’Aqua, Luke Mason, Tony Charman, Bethany Oakley, Thomas Bourgeron, Christian Beckmann, Jan K. Buitelaar, Celso Arango, Tobias Banaschewski, Andreas G. Chiocchetti, Christine M. Freitag, Elke Hattingen, Dilja Krueger-Burg, Michael J. Schmeisser, Jonathan Repple, Andreas Reif & Declan G. Murphy |
| 264 | 1 | |c 22 July 2025 | |
| 300 | |b Illustrationen, Diagramme | ||
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 13.11.2025 | ||
| 520 | |a Imaging transcriptomics has become a power tool for linking imaging-derived phenotypes (IDPs) to genomic mechanisms. Yet, its potential for guiding CNS drug discovery remains underexplored. Here, utilizing spatially-dense representations of the human brain transcriptome, we present an analytical framework for the transcriptomic decoding of high-resolution surface-based neuroimaging patterns, and for linking IDPs to the transcriptomic landscape of complex neurotransmission systems in vivo. Leveraging publicly available Positron Emission Tomography (PET) data, we initially validated our approach against molecular targets with a high correspondence between gene expression and protein binding. Subsequently, we used the cortical gene expression profiles of candidate genes to dissect two discrete classes of GABAA-receptor subunits, each characterized by a distinct cortical expression pattern, and to link these to specific behavioural symptoms and traits. Our approach thus represents a future avenue for in vivo pharmacotranscriptomics that may guide the development of targeted pharmacotherapies and personalized interventions. | ||
| 650 | 4 | |a Biophysical models | |
| 650 | 4 | |a Brain | |
| 700 | 1 | |a Pretzsch, Charlotte M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Leyhausen, Johanna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Berg, Lisa M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gurr, Caroline |e VerfasserIn |4 aut | |
| 700 | 1 | |a Seelemeyer, Hanna |e VerfasserIn |4 aut | |
| 700 | 1 | |a McAlonan, Grainne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Puts, Nicolaas A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Loth, Eva |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dell’Aqua, Flavio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mason, Luke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Charman, Tony |e VerfasserIn |4 aut | |
| 700 | 1 | |a Oakley, Bethany |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bourgeron, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Beckmann, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Buitelaar, Jan K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Arango, Celso |e VerfasserIn |4 aut | |
| 700 | 1 | |a Banaschewski, Tobias |d 1961- |e VerfasserIn |0 (DE-588)115856110 |0 (DE-627)507227301 |0 (DE-576)178364703 |4 aut | |
| 700 | 1 | |a Chiocchetti, Andreas G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Freitag, Christine M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hattingen, Elke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krueger-Burg, Dilja |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmeisser, Michael J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Repple, Jonathan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Reif, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Murphy, Declan G. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature Communications |d [London] : Springer Nature, 2010 |g 16(2025), Artikel-ID 6727, Seite 1-14 |h Online-Ressource |w (DE-627)626457688 |w (DE-600)2553671-0 |w (DE-576)331555905 |x 2041-1723 |7 nnas |a Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics |
| 773 | 1 | 8 | |g volume:16 |g year:2025 |g elocationid:6727 |g pages:1-14 |g extent:14 |a Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41467-025-61927-3 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41467-025-61927-3 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20251113 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 115856110 |a Banaschewski, Tobias |m 115856110:Banaschewski, Tobias |d 60000 |e 60000PB115856110 |k 0/60000/ |p 18 | ||
| 999 | |a KXP-PPN1941078176 |e 4804326219 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics","title":"Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics"}],"note":["Gesehen am 13.11.2025"],"origin":[{"dateIssuedDisp":"22 July 2025","dateIssuedKey":"2025"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"relHost":[{"language":["eng"],"part":{"pages":"1-14","year":"2025","text":"16(2025), Artikel-ID 6727, Seite 1-14","extent":"14","volume":"16"},"title":[{"title":"Nature Communications","title_sort":"Nature Communications"}],"pubHistory":["2010-"],"note":["Gesehen am 13.06.24"],"origin":[{"publisherPlace":"[London] ; [London]","publisher":"Springer Nature ; Nature Publishing Group UK","dateIssuedDisp":"[2010]-"}],"disp":"Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomicsNature Communications","type":{"media":"Online-Ressource","bibl":"periodical"},"physDesc":[{"extent":"Online-Ressource"}],"recId":"626457688","id":{"eki":["626457688"],"zdb":["2553671-0"],"issn":["2041-1723"]}}],"recId":"1941078176","physDesc":[{"extent":"14 S.","noteIll":"Illustrationen, Diagramme"}],"name":{"displayForm":["Christine Ecker, Charlotte M. Pretzsch, Johanna Leyhausen, Lisa M. Berg, Caroline Gurr, Hanna Seelemeyer, Grainne McAlonan, Nicolaas A. Puts, Eva Loth, Flavio Dell’Aqua, Luke Mason, Tony Charman, Bethany Oakley, Thomas Bourgeron, Christian Beckmann, Jan K. Buitelaar, Celso Arango, Tobias Banaschewski, Andreas G. Chiocchetti, Christine M. Freitag, Elke Hattingen, Dilja Krueger-Burg, Michael J. Schmeisser, Jonathan Repple, Andreas Reif & Declan G. Murphy"]},"id":{"doi":["10.1038/s41467-025-61927-3"],"eki":["1941078176"]},"person":[{"family":"Ecker","display":"Ecker, Christine","role":"aut","given":"Christine"},{"family":"Pretzsch","display":"Pretzsch, Charlotte M.","role":"aut","given":"Charlotte M."},{"given":"Johanna","role":"aut","family":"Leyhausen","display":"Leyhausen, Johanna"},{"display":"Berg, Lisa M.","family":"Berg","given":"Lisa M.","role":"aut"},{"role":"aut","given":"Caroline","family":"Gurr","display":"Gurr, Caroline"},{"role":"aut","given":"Hanna","display":"Seelemeyer, Hanna","family":"Seelemeyer"},{"role":"aut","given":"Grainne","display":"McAlonan, Grainne","family":"McAlonan"},{"family":"Puts","display":"Puts, Nicolaas A.","role":"aut","given":"Nicolaas A."},{"role":"aut","given":"Eva","family":"Loth","display":"Loth, Eva"},{"role":"aut","given":"Flavio","display":"Dell’Aqua, Flavio","family":"Dell’Aqua"},{"family":"Mason","display":"Mason, Luke","given":"Luke","role":"aut"},{"family":"Charman","display":"Charman, Tony","given":"Tony","role":"aut"},{"role":"aut","given":"Bethany","display":"Oakley, Bethany","family":"Oakley"},{"family":"Bourgeron","display":"Bourgeron, Thomas","role":"aut","given":"Thomas"},{"display":"Beckmann, Christian","family":"Beckmann","given":"Christian","role":"aut"},{"display":"Buitelaar, Jan K.","family":"Buitelaar","given":"Jan K.","role":"aut"},{"role":"aut","given":"Celso","display":"Arango, Celso","family":"Arango"},{"role":"aut","given":"Tobias","family":"Banaschewski","display":"Banaschewski, Tobias"},{"display":"Chiocchetti, Andreas G.","family":"Chiocchetti","role":"aut","given":"Andreas G."},{"family":"Freitag","display":"Freitag, Christine M.","given":"Christine M.","role":"aut"},{"given":"Elke","role":"aut","family":"Hattingen","display":"Hattingen, Elke"},{"role":"aut","given":"Dilja","family":"Krueger-Burg","display":"Krueger-Burg, Dilja"},{"display":"Schmeisser, Michael J.","family":"Schmeisser","given":"Michael J.","role":"aut"},{"family":"Repple","display":"Repple, Jonathan","role":"aut","given":"Jonathan"},{"family":"Reif","display":"Reif, Andreas","given":"Andreas","role":"aut"},{"role":"aut","given":"Declan G.","display":"Murphy, Declan G.","family":"Murphy"}],"language":["eng"]} | ||
| SRT | |a ECKERCHRISTRANSCRIPT2220 | ||