Cardioplegic machine perfusion of hearts donated after circulatory death
We compared the effects of ex-vivo machine perfusion (EVMP) of hearts donated after circulatory death (DCD) with the single-shot solutions HTK-N and Del Nido cardioplegia (DNC) on left-ventricular (LV) contractility and myocardial microcirculation. In a DCD pig model, hearts were maintained by EVMP...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
08 September 2025
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| In: |
Journal of cardiovascular translational research
Year: 2025, Jahrgang: 18, Heft: 5, Pages: 1192-1203 |
| ISSN: | 1937-5395 |
| DOI: | 10.1007/s12265-025-10694-z |
| Online-Zugang: | Resolving-System, kostenfrei: https://doi.org/10.1007/s12265-025-10694-z Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s12265-025-10694-z 
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| Verfasserangaben: | Lars Saemann, Kristin Wächter, Anne Großkopf, Sabine Pohl, Adrian-Iustin Georgevici, Fabio Hoorn, Sevil Korkmaz-Icöz, Matthias Karck, Andreas Simm, Gábor Szabó |
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| 245 | 1 | 0 | |a Cardioplegic machine perfusion of hearts donated after circulatory death |c Lars Saemann, Kristin Wächter, Anne Großkopf, Sabine Pohl, Adrian-Iustin Georgevici, Fabio Hoorn, Sevil Korkmaz-Icöz, Matthias Karck, Andreas Simm, Gábor Szabó |
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| 520 | |a We compared the effects of ex-vivo machine perfusion (EVMP) of hearts donated after circulatory death (DCD) with the single-shot solutions HTK-N and Del Nido cardioplegia (DNC) on left-ventricular (LV) contractility and myocardial microcirculation. In a DCD pig model, hearts were maintained by EVMP with hypothermic, oxygenated HTK-N (DCD-HTK-N; N = 8) or DNC (DCD-DNC; N = 8) followed by reperfusion with blood, including assessment of contractility and microcirculation with Laser-Doppler-Flow (LDF). We performed transcriptomics using microarrays. In DCD-HTK-N, the ESP, dp/dtmax and dp/dtmin were significantly higher (p < 0.05) compared to DCD-DNC. Relative LDF was higher in DCD-HTK-N vs. DCD-DNC. Pathways related to inflammatory mediators, cAMP, ion channels, intracellular signaling, and cell death were regulated differently. In DCD-HTK-N, longevity-associated pathways were up-, and ageing-associated pathways were downregulated. EVMP of DCD hearts with HTK-N results in a superior LV function, microcirculation, and regulation of pathways with short- and long-term relevance compared to DNC. | ||
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| 650 | 4 | |a Donation after circulatory death | |
| 650 | 4 | |a Heart transplantation | |
| 650 | 4 | |a HTK-N | |
| 650 | 4 | |a Longevity | |
| 650 | 4 | |a Machine perfusion | |
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