Urinary peptide signature distinguishes autosomal recessive polycystic kidney disease from other causes of chronic kidney disease
The diagnosis of autosomal recessive polycystic kidney disease (ARPKD) can be hampered by its pronounced phenotypic variability and ARPKD-mimicking phenocopies. Here, for the first time we specifically studied the urinary peptidome of patients with ARPKD with the aim of distinguishing ARPKD from oth...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2025
|
| In: |
Clinical kidney journal
Year: 2025, Jahrgang: 18, Heft: 5, Pages: 1-9 |
| ISSN: | 2048-8513 |
| DOI: | 10.1093/ckj/sfaf093 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1093/ckj/sfaf093 Verlag, kostenfrei, Volltext: https://academic.oup.com/ckj/article/18/5/sfaf093/8113999?login=true 
|
| Verfasserangaben: | Kathrin Burgmaier, Bénédicte Buffin-Meyer, Julie Klein, Brian Becknell, Daryl McLeod, Jan Boeckhaus, Oliver Gross, Claudia Dafinger, Justyna Siwy, Stéphane Decramer, Franz Schaefer, Max C Liebau and Joost P Schanstra; on behalf of the ARegPKD Consortium |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1941283918 | ||
| 003 | DE-627 | ||
| 005 | 20251114115041.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251114s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/ckj/sfaf093 |2 doi | |
| 035 | |a (DE-627)1941283918 | ||
| 035 | |a (DE-599)KXP1941283918 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Burgmaier, Kathrin |e VerfasserIn |0 (DE-588)1190046393 |0 (DE-627)1668727986 |4 aut | |
| 245 | 1 | 0 | |a Urinary peptide signature distinguishes autosomal recessive polycystic kidney disease from other causes of chronic kidney disease |c Kathrin Burgmaier, Bénédicte Buffin-Meyer, Julie Klein, Brian Becknell, Daryl McLeod, Jan Boeckhaus, Oliver Gross, Claudia Dafinger, Justyna Siwy, Stéphane Decramer, Franz Schaefer, Max C Liebau and Joost P Schanstra; on behalf of the ARegPKD Consortium |
| 264 | 1 | |c May 2025 | |
| 300 | |b Diagramme | ||
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 15. April 2025, Artikelversion: 01. Mai 2025 | ||
| 500 | |a Gesehen am 14.11.2025 | ||
| 520 | |a The diagnosis of autosomal recessive polycystic kidney disease (ARPKD) can be hampered by its pronounced phenotypic variability and ARPKD-mimicking phenocopies. Here, for the first time we specifically studied the urinary peptidome of patients with ARPKD with the aim of distinguishing ARPKD from other causes of chronic kidney disease (CKD).Fifty-eight urine samples from patients with ARPKD, 662 urine samples from paediatric patients with CKD with various other CKD aetiologies and 45 samples from healthy children were included. The urinary peptidome was analysed by capillary electrophoresis/mass spectrometry.A 77-peptide signature specific for ARPKD was identified. Application of this signature in a matched random validation set of 19 samples of patients with ARPKD, 23 samples from patients with other CKD and 21 samples from healthy individuals led to a sensitivity of 84.2% [95% confidence interval (CI) 60.4-96.6], a specificity of 100% (95% CI 92.0-100%) and an area under the receiver operating characteristics curve (AUC) of 0.994 (95% CI 0.93-1.00). The 77-peptide signature displayed a specificity of 76.1% (95% CI 72.4-79.5) and an AUC of 0.88 (95% CI 0.85-0.90) in 591 samples from non-matched children with various CKD aetiologies. The signature was primarily (83%) composed of collagen fragments indicating structural damage. Of the remaining peptides, five originated from proteins known to bind to calcium potentially linking the current work to defaults in calcium signalling in polycystic disease.We determined a urinary peptide signature that identifies paediatric patients with ARPKD with high precision among a population of children with CKD. Knowledge of the identity of the underlying peptides offers a novel starting point for discussion of possible pathophysiological processes involved in ARPKD. | ||
| 700 | 1 | |a Buffin-Meyer, Bénédicte |e VerfasserIn |4 aut | |
| 700 | 1 | |a Klein, Julie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Becknell, Brian |e VerfasserIn |4 aut | |
| 700 | 1 | |a McLeod, Daryl |e VerfasserIn |4 aut | |
| 700 | 1 | |a Boeckhaus, Jan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gross, Oliver |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dafinger, Claudia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Siwy, Justyna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Decramer, Stéphane |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schaefer, Franz |d 1961- |e VerfasserIn |0 (DE-588)1023365383 |0 (DE-627)718365577 |0 (DE-576)366705598 |4 aut | |
| 700 | 1 | |a Liebau, Max C |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schanstra, Joost P |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical kidney journal |d Oxford : Oxford Univ. Press, 2012 |g 18(2025), 5 vom: Mai, Artikel-ID sfaf093, Seite 1-9 |h Online-Ressource |w (DE-627)689395191 |w (DE-600)2656786-6 |w (DE-576)363260714 |x 2048-8513 |7 nnas |a Urinary peptide signature distinguishes autosomal recessive polycystic kidney disease from other causes of chronic kidney disease |
| 773 | 1 | 8 | |g volume:18 |g year:2025 |g number:5 |g month:05 |g elocationid:sfaf093 |g pages:1-9 |g extent:9 |a Urinary peptide signature distinguishes autosomal recessive polycystic kidney disease from other causes of chronic kidney disease |
| 856 | 4 | 0 | |u https://doi.org/10.1093/ckj/sfaf093 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://academic.oup.com/ckj/article/18/5/sfaf093/8113999?login=true |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20251114 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1023365383 |a Schaefer, Franz |m 1023365383:Schaefer, Franz |d 910000 |d 910500 |d 50000 |e 910000PS1023365383 |e 910500PS1023365383 |e 50000PS1023365383 |k 0/910000/ |k 1/910000/910500/ |k 0/50000/ |p 11 | ||
| 999 | |a KXP-PPN1941283918 |e 4806075795 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Urinary peptide signature distinguishes autosomal recessive polycystic kidney disease from other causes of chronic kidney disease","title":"Urinary peptide signature distinguishes autosomal recessive polycystic kidney disease from other causes of chronic kidney disease"}],"physDesc":[{"noteIll":"Diagramme","extent":"9 S."}],"relHost":[{"language":["eng"],"titleAlt":[{"title":"Clin Kidney J"},{"title":"CKJ"}],"pubHistory":["5.2012 -"],"note":["Gesehen am 27.05.2020"],"origin":[{"publisher":"Oxford Univ. Press","dateIssuedDisp":"2012-","dateIssuedKey":"2012","publisherPlace":"Oxford"}],"disp":"Urinary peptide signature distinguishes autosomal recessive polycystic kidney disease from other causes of chronic kidney diseaseClinical kidney journal","type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"689395191","id":{"issn":["2048-8513"],"eki":["689395191"],"zdb":["2656786-6"]},"title":[{"title":"Clinical kidney journal","subtitle":"CKJ","title_sort":"Clinical kidney journal"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"18","text":"18(2025), 5 vom: Mai, Artikel-ID sfaf093, Seite 1-9","issue":"5","year":"2025","pages":"1-9","extent":"9"}}],"name":{"displayForm":["Kathrin Burgmaier, Bénédicte Buffin-Meyer, Julie Klein, Brian Becknell, Daryl McLeod, Jan Boeckhaus, Oliver Gross, Claudia Dafinger, Justyna Siwy, Stéphane Decramer, Franz Schaefer, Max C Liebau and Joost P Schanstra; on behalf of the ARegPKD Consortium"]},"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"May 2025"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1093/ckj/sfaf093"],"eki":["1941283918"]},"recId":"1941283918","person":[{"role":"aut","family":"Burgmaier","display":"Burgmaier, Kathrin","given":"Kathrin"},{"display":"Buffin-Meyer, Bénédicte","role":"aut","family":"Buffin-Meyer","given":"Bénédicte"},{"given":"Julie","display":"Klein, Julie","role":"aut","family":"Klein"},{"given":"Brian","display":"Becknell, Brian","family":"Becknell","role":"aut"},{"given":"Daryl","role":"aut","family":"McLeod","display":"McLeod, Daryl"},{"given":"Jan","family":"Boeckhaus","role":"aut","display":"Boeckhaus, Jan"},{"given":"Oliver","family":"Gross","role":"aut","display":"Gross, Oliver"},{"display":"Dafinger, Claudia","family":"Dafinger","role":"aut","given":"Claudia"},{"display":"Siwy, Justyna","role":"aut","family":"Siwy","given":"Justyna"},{"role":"aut","family":"Decramer","display":"Decramer, Stéphane","given":"Stéphane"},{"display":"Schaefer, Franz","role":"aut","family":"Schaefer","given":"Franz"},{"given":"Max C","role":"aut","family":"Liebau","display":"Liebau, Max C"},{"given":"Joost P","family":"Schanstra","role":"aut","display":"Schanstra, Joost P"}],"language":["eng"],"note":["Online verfügbar: 15. April 2025, Artikelversion: 01. Mai 2025","Gesehen am 14.11.2025"]} | ||
| SRT | |a BURGMAIERKURINARYPEP2025 | ||