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A tactile discrimination task to study neuronal dynamics in freely-moving mice

Sensory discrimination tasks are valuable tools to study neuronal mechanisms of perception and learning, yet most rodent paradigms rely on head fixation. Here, we present a whisker-dependent go/no-go discrimination task for freely moving mice, compatible with high-resolution electrophysiology and ca...

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Main Authors: Heimburg, Filippo (Author) , Saluti, Nadin Mari (Author) , Timm, Josephine (Author) , Adlakha, Avi (Author) , Bortolozzo-Gleich, Maria Helena (Author) , Martín-Cortecero, Jesús (Author) , Castelanelli, Melina (Author) , Klumpp, Matthias (Author) , Embray, Lee (Author) , Both, Martin (Author) , Kuner, Thomas (Author) , Groh, Alexander (Author)
Format: Article (Journal)
Language:English
Published: 11 July 2025
In: Nature Communications
Year: 2025, Volume: 16, Pages: 1-20
ISSN:2041-1723
DOI:10.1038/s41467-025-61792-0
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-61792-0
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-61792-0
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Author Notes:Filippo Heimburg, Nadin Mari Saluti, Josephine Timm, Avi Adlakha, Maria Helena Bortolozzo-Gleich, Jesús Martín-Cortecero, Melina Castelanelli, Matthias Klumpp, Lee Embray, Martin Both, Thomas Kuner & Alexander Groh
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Summary:Sensory discrimination tasks are valuable tools to study neuronal mechanisms of perception and learning, yet most rodent paradigms rely on head fixation. Here, we present a whisker-dependent go/no-go discrimination task for freely moving mice, compatible with high-resolution electrophysiology and calcium imaging. Adult male mice rapidly learned to discriminate aperture widths while foraging on a linear platform, enabling investigations of tactile thresholds, rule reversals, and behavioral flexibility. Neural recordings revealed distributed tactile coding across the thalamocortical system, with units tuned to both sensory and motor features, including whisking, head angle, and spatial position. Aperture selectivity emerged in the barrel cortex during learning, and cortical lesions impaired performance, highlighting cortical involvement in learning and task execution. The setup is modular, automated, and supports simultaneous recordings and imaging aligned to naturalistic behavior. This platform provides a powerful tool to dissect sensory processing and learning in ethologically relevant conditions.
Item Description:Gesehen am 17.11.2025
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-025-61792-0

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