Reirradiation of recurrent glioblastoma: results from a single-center retrospective cohort study
Purpose - The management of recurrent glioblastoma (rGBM) remains a clinical challenge, with only limited therapeutic options available to date. Reirradiation may offer a progression-free survival (PFS) benefit in selected cases, but data are scarce. - Methods - Consecutive patients from the last 10...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 2025
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| In: |
Clinical and translational radiation oncology
Year: 2025, Jahrgang: 55, Pages: 1-8 |
| ISSN: | 2405-6308 |
| DOI: | 10.1016/j.ctro.2025.101029 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ctro.2025.101029 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2405630825001211 
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| Verfasserangaben: | Cas S. Dejonckheere, Thomas Zeyen, Cathrina Duffy, Yannik C. Layer, Anna-Laura Potthoff, Barbara D. Wichtmann, Lea L. Friker, Davide Scafa, Christina Leitzen, Younèss Nour, Fabian Kugel, Niklas Schäfer, Alexander Radbruch, Hartmut Vatter, Anca-Ligia Grosu, Ulrich Herrlinger, Matthias Schneider, Frank A. Giordano, Gustavo R. Sarria, Eleni Gkika, Julian P. Layer |
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| 245 | 1 | 0 | |a Reirradiation of recurrent glioblastoma |b results from a single-center retrospective cohort study |c Cas S. Dejonckheere, Thomas Zeyen, Cathrina Duffy, Yannik C. Layer, Anna-Laura Potthoff, Barbara D. Wichtmann, Lea L. Friker, Davide Scafa, Christina Leitzen, Younèss Nour, Fabian Kugel, Niklas Schäfer, Alexander Radbruch, Hartmut Vatter, Anca-Ligia Grosu, Ulrich Herrlinger, Matthias Schneider, Frank A. Giordano, Gustavo R. Sarria, Eleni Gkika, Julian P. Layer |
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| 500 | |a Online verfügbar: 8. August 2025, Artikelversion: 9. August 2025 | ||
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| 520 | |a Purpose - The management of recurrent glioblastoma (rGBM) remains a clinical challenge, with only limited therapeutic options available to date. Reirradiation may offer a progression-free survival (PFS) benefit in selected cases, but data are scarce. - Methods - Consecutive patients from the last 10 years with GBM (CNS WHO grade 4, IDH-wildtype) who underwent at least one additional course of cranial radiotherapy for suspected or histopathologically confirmed rGBM at a tertiary neuro-oncological center were retrospectively analyzed. The primary endpoint was PFS, secondary endpoints included reirradiation-related adverse event rates, with a particular focus on radiation necrosis (RN). - Results - Fifty-nine patients were included with a median follow-up (range) of 8.7 (0.5-48.0) months after reirradiation. The median time to first recurrence was 15 (4-89) months, with the majority occurring in-field (59.7 %). The EQD2⍺/β=10 ranged from 31.3-80.2 Gy with a median prescription dose of 42 Gy. Reirradiation was combined with systemic therapy in 81.4 % of patients. No grade 3-5 acute reirradiation-related adverse events were observed. RN was diagnosed in 16.9 % of patients (80 % grade 2 and 20 % grade 3), with a notably low rate in those receiving anti-VEGF therapy parallel to reirradiation. RN risk was independent of reirradiation volume or dose (p = 0.15 and 0.43, respectively). The disease control rate following reirradiation was 83.6 % and the median PFS was 5.9 (0.5-48.0) months. Concomitant chemotherapy or anti-VEGF therapy was significantly associated with improved outcomes (p = 0.049), whereas smaller reirradiation volumes demonstrated a non-significant trend towards longer PFS (p = 0.23). - Conclusion - In this retrospective analysis, reirradiation for rGBM was feasible and safe, conferring a potential PFS benefit in selected patients. Bevacizumab emerged as a particularly promising combination partner, contributing to both RN prevention and enhanced efficacy. | ||
| 650 | 4 | |a Glioblastoma | |
| 650 | 4 | |a Radiation necrosis | |
| 650 | 4 | |a Recurrence | |
| 650 | 4 | |a Reirradiation | |
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| 700 | 1 | |a Vatter, Hartmut |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grosu, Anca-Ligia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Herrlinger, Ulrich |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schneider, Matthias |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Sarria, Gustavo R. |e VerfasserIn |4 aut | |
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