Associations of ANGPTL proteins and complexes with progression of coronary artery calcification and coronary events
Background and aims - Angiopoietin-like protein 8 (ANGPTL8) forms complexes with ANGPTL3 and ANGPTL4 to regulate lipoprotein lipase (LPL) activity, and decreased LPL activity is an established cardiovascular risk factor. Serum levels of ANGPTL4/8 and C-terminal domain-containing ANGPTL4 (CD-ANGPTL4)...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2025
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| In: |
Atherosclerosis
Year: 2025, Jahrgang: 409, Pages: 1-9 |
| ISSN: | 1879-1484 |
| DOI: | 10.1016/j.atherosclerosis.2025.120485 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.atherosclerosis.2025.120485 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0021915025013838 
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| Verfasserangaben: | Günther Silbernagel, Halle Higbie, Tanja Meininger, Deven Lemen, Hongxia Li, Yan Q. Chen, Yi Wen, Eugene Y. Zhen, Yue-Wei Qian, Polina Korovianskaia, Hans J. Trampisch, Hubert Scharnagl, Winfried März, Andreas Stang, Raimund Erbel, Robert J. Konrad, Börge Schmidt |
MARC
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| 245 | 1 | 0 | |a Associations of ANGPTL proteins and complexes with progression of coronary artery calcification and coronary events |c Günther Silbernagel, Halle Higbie, Tanja Meininger, Deven Lemen, Hongxia Li, Yan Q. Chen, Yi Wen, Eugene Y. Zhen, Yue-Wei Qian, Polina Korovianskaia, Hans J. Trampisch, Hubert Scharnagl, Winfried März, Andreas Stang, Raimund Erbel, Robert J. Konrad, Börge Schmidt |
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| 500 | |a Online verfügbar: 13. August 2025, Artikelversion: 16. August 2025 | ||
| 500 | |a Gesehen am 18.11.2025 | ||
| 520 | |a Background and aims - Angiopoietin-like protein 8 (ANGPTL8) forms complexes with ANGPTL3 and ANGPTL4 to regulate lipoprotein lipase (LPL) activity, and decreased LPL activity is an established cardiovascular risk factor. Serum levels of ANGPTL4/8 and C-terminal domain-containing ANGPTL4 (CD-ANGPTL4) are positively associated with cardiovascular death, however, the underlying mechanisms remain incompletely understood. The present study investigated relationships of ANGPTL3, ANGPTL3/8, CD-ANGPTL4, and ANGPTL4/8 with coronary artery calcification (CAC) progression (using Agatston scores) and incident coronary events. - Methods - ANGPTL3, ANGPTL3/8, CD-ANGPTL4, and ANGPTL4/8, were measured using dedicated immunoassays in participants of the Heinz Nixdorf Recall (HNR) study, an unselected, population-based cohort of subjects free from cardiovascular disease at baseline. CAC measurements were performed at baseline and after 5 years in 2887 participants, and there was follow-up for coronary events (median duration 18.8 years). - Results - Median Agatston scores increased over 5 years from 6.70 (t0) to 24.75 (t1), and 315 participants experienced a coronary event. Concentrations of ANGPTL3 and ANGPTL3/8 were not associated with Agatston score progression. ANGPTL3 was associated with incident coronary events, whereas ANGPTL3/8 was not. In contrast, CD-ANGPTL4 and ANGPTL4/8 were positively associated with both Agatston score progression and incident coronary events. - Conclusions - Associations of ANGPTL3 and ANGPTL3/8 with coronary atherosclerosis progression and incident coronary events were inconsistent, while CD-ANGPTL4 and ANGPTL4/8 were associated with both coronary atherosclerosis progression and incident coronary events. Associations of ANGPTL4/8 and CD-ANGPTL4 with cardiovascular events may reflect progression of coronary atherosclerosis conferred by diabetes, inflammation, or the potential intrinsic effects of CD-ANGPTL4 and ANGPTL4/8. | ||
| 650 | 4 | |a ANGPTL4/8 | |
| 650 | 4 | |a CD-ANGPTL4 | |
| 650 | 4 | |a Coronary artery calcification (CAC) | |
| 650 | 4 | |a Coronary event | |
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| 700 | 1 | |a Li, Hongxia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chen, Yan Q. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wen, Yi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhen, Eugene Y. |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Korovianskaia, Polina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Trampisch, Hans J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Scharnagl, Hubert |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Stang, Andreas |e VerfasserIn |4 aut | |
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