Cover Image

Identification and external validation of a problem cannabis risk network

Background - Cannabis use is common, particularly during emerging adulthood when brain development is ongoing, and its use is associated with harmful outcomes for a subset of people. An improved understanding of the neural mechanisms underlying risk for problem-level use is critical to facilitate th...

Full description

Saved in:
Bibliographic Details
Main Authors: Lichenstein, Sarah D. (Author) , Kiluk, Brian D. (Author) , Potenza, Marc N. (Author) , Garavan, Hugh (Author) , Chaarani, Bader (Author) , Banaschewski, Tobias (Author) , Bokde, Arun L. W. (Author) , Desrivières, Sylvane (Author) , Flor, Herta (Author) , Grigis, Antoine (Author) , Gowland, Penny (Author) , Heinz, Andreas (Author) , Brühl, Rüdiger (Author) , Martinot, Jean-Luc (Author) , Paillère Martinot, Marie-Laure (Author) , Artiges, Eric (Author) , Nees, Frauke (Author) , Orfanos, Dimitri Papadopoulos (Author) , Poustka, Luise (Author) , Hohmann, Sarah (Author) , Holz, Nathalie E. (Author) , Baeuchl, Christian (Author) , Smolka, Michael (Author) , Vaidya, Nilakshi (Author) , Walter, Henrik (Author) , Whelan, Robert (Author) , Schumann, Gunter (Author) , Pearlson, Godfrey (Author) , Yip, Sarah W. (Author)
Format: Article (Journal)
Language:English
Published: 15 October 2025
In: Biological psychiatry
Year: 2025, Volume: 98, Issue: 8, Pages: 586-596
ISSN:1873-2402
DOI:10.1016/j.biopsych.2025.01.022
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.biopsych.2025.01.022
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0006322325000654
Get full text
Author Notes:Sarah D. Lichenstein, Brian D. Kiluk, Marc N. Potenza, Hugh Garavan, Bader Chaarani, Tobias Banaschewski, Arun L.W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Nathalie Holz, Christian Baeuchl, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Godfrey Pearlson, and Sarah W. Yip

MARC

LEADER 00000caa a2200000 c 4500
001 1941473091
003 DE-627
005 20251119171516.0
007 cr uuu---uuuuu
008 251118s2025 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.biopsych.2025.01.022  |2 doi 
035 |a (DE-627)1941473091 
035 |a (DE-599)KXP1941473091 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 11  |2 sdnb 
100 1 |a Lichenstein, Sarah D.  |e VerfasserIn  |0 (DE-588)1381904041  |0 (DE-627)1941473970  |4 aut 
245 1 0 |a Identification and external validation of a problem cannabis risk network  |c Sarah D. Lichenstein, Brian D. Kiluk, Marc N. Potenza, Hugh Garavan, Bader Chaarani, Tobias Banaschewski, Arun L.W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Nathalie Holz, Christian Baeuchl, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Godfrey Pearlson, and Sarah W. Yip 
264 1 |c 15 October 2025 
300 |b Diagramme 
300 |a 11 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Online verfügbar: 3. Februar 2025, Artikelversion: 17. September 2025 
500 |a Gesehen am 18.11.2025 
520 |a Background - Cannabis use is common, particularly during emerging adulthood when brain development is ongoing, and its use is associated with harmful outcomes for a subset of people. An improved understanding of the neural mechanisms underlying risk for problem-level use is critical to facilitate the development of more effective prevention and treatment approaches. - Methods - In the current study, we applied a whole-brain, data-driven, machine learning approach to identify neural features predictive of problem-level cannabis use in a nonclinical sample of college students (n = 191, 58% female) based on reward task functional connectivity data. We further examined whether the identified network would generalize to predict cannabis use in an independent sample of European adolescents/emerging adults (n = 1320, 53% female), whether it would predict clinical characteristics among adults seeking treatment for cannabis use disorder (n = 33, 9% female), and whether it was specific for predicting cannabis versus alcohol use outcomes across datasets. - Results - Results demonstrated identification of a problem cannabis risk network, which generalized to predict cannabis use in an independent sample of adolescents and was linked to increased addiction severity and poorer treatment outcome in a third sample of treatment-seeking adults. Furthermore, the identified network was specific for predicting cannabis versus alcohol use outcomes across all 3 datasets. - Conclusions - Findings provide insight into neural mechanisms of risk for problem-level cannabis use among adolescents/emerging adults. Future work is needed to assess whether targeting this network can improve prevention and treatment outcomes. 
650 4 |a Emerging adulthood 
650 4 |a External replication 
650 4 |a Functional connectivity 
650 4 |a Marijuana 
650 4 |a Neuromarker 
650 4 |a Predictive modeling 
700 1 |a Kiluk, Brian D.  |e VerfasserIn  |4 aut 
700 1 |a Potenza, Marc N.  |e VerfasserIn  |4 aut 
700 1 |a Garavan, Hugh  |e VerfasserIn  |4 aut 
700 1 |a Chaarani, Bader  |e VerfasserIn  |4 aut 
700 1 |a Banaschewski, Tobias  |d 1961-  |e VerfasserIn  |0 (DE-588)115856110  |0 (DE-627)507227301  |0 (DE-576)178364703  |4 aut 
700 1 |a Bokde, Arun L. W.  |e VerfasserIn  |4 aut 
700 1 |a Desrivières, Sylvane  |e VerfasserIn  |4 aut 
700 1 |a Flor, Herta  |d 1954-  |e VerfasserIn  |0 (DE-588)110841816  |0 (DE-627)636273695  |0 (DE-576)160967732  |4 aut 
700 1 |a Grigis, Antoine  |e VerfasserIn  |4 aut 
700 1 |a Gowland, Penny  |e VerfasserIn  |4 aut 
700 1 |a Heinz, Andreas  |e VerfasserIn  |4 aut 
700 1 |a Brühl, Rüdiger  |e VerfasserIn  |4 aut 
700 1 |a Martinot, Jean-Luc  |e VerfasserIn  |4 aut 
700 1 |a Paillère Martinot, Marie-Laure  |e VerfasserIn  |4 aut 
700 1 |a Artiges, Eric  |e VerfasserIn  |4 aut 
700 1 |a Nees, Frauke  |e VerfasserIn  |0 (DE-588)140286527  |0 (DE-627)703627244  |0 (DE-576)325389764  |4 aut 
700 1 |a Orfanos, Dimitri Papadopoulos  |e VerfasserIn  |4 aut 
700 1 |a Poustka, Luise  |e VerfasserIn  |0 (DE-588)1032378239  |0 (DE-627)738388688  |0 (DE-576)380005190  |4 aut 
700 1 |a Hohmann, Sarah  |d 1978-  |e VerfasserIn  |0 (DE-588)131743473  |0 (DE-627)513596542  |0 (DE-576)298711486  |4 aut 
700 1 |a Holz, Nathalie E.  |d 1985-  |e VerfasserIn  |0 (DE-588)1093240776  |0 (DE-627)853204470  |0 (DE-576)462656926  |4 aut 
700 1 |a Baeuchl, Christian  |e VerfasserIn  |4 aut 
700 1 |a Smolka, Michael  |e VerfasserIn  |0 (DE-588)1073229319  |0 (DE-627)828684685  |0 (DE-576)43475286X  |4 aut 
700 1 |a Vaidya, Nilakshi  |e VerfasserIn  |4 aut 
700 1 |a Walter, Henrik  |e VerfasserIn  |4 aut 
700 1 |a Whelan, Robert  |e VerfasserIn  |4 aut 
700 1 |a Schumann, Gunter  |e VerfasserIn  |4 aut 
700 1 |a Pearlson, Godfrey  |e VerfasserIn  |4 aut 
700 1 |a Yip, Sarah W.  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Biological psychiatry  |d Amsterdam [u.a.] : Elsevier Science, 1985  |g 98(2025), 8 vom: Okt., Seite 586-596  |h Online-Ressource  |w (DE-627)306654296  |w (DE-600)1499907-9  |w (DE-576)115780807  |x 1873-2402  |7 nnas  |a Identification and external validation of a problem cannabis risk network 
773 1 8 |g volume:98  |g year:2025  |g number:8  |g month:10  |g pages:586-596  |g extent:11  |a Identification and external validation of a problem cannabis risk network 
856 4 0 |u https://doi.org/10.1016/j.biopsych.2025.01.022  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0006322325000654  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20251118 
993 |a Article 
994 |a 2025 
998 |g 1093240776  |a Holz, Nathalie E.  |m 1093240776:Holz, Nathalie E.  |d 60000  |e 60000PH1093240776  |k 0/60000/  |p 21 
998 |g 131743473  |a Hohmann, Sarah  |m 131743473:Hohmann, Sarah  |d 60000  |e 60000PH131743473  |k 0/60000/  |p 20 
998 |g 1032378239  |a Poustka, Luise  |m 1032378239:Poustka, Luise  |d 910000  |d 910600  |e 910000PP1032378239  |e 910600PP1032378239  |k 0/910000/  |k 1/910000/910600/  |p 19 
998 |g 110841816  |a Flor, Herta  |m 110841816:Flor, Herta  |d 60000  |e 60000PF110841816  |k 0/60000/  |p 9 
998 |g 115856110  |a Banaschewski, Tobias  |m 115856110:Banaschewski, Tobias  |d 60000  |e 60000PB115856110  |k 0/60000/  |p 6 
999 |a KXP-PPN1941473091  |e 4808169606 
BIB |a Y 
SER |a journal 
JSO |a {"person":[{"family":"Lichenstein","display":"Lichenstein, Sarah D.","given":"Sarah D.","role":"aut"},{"family":"Kiluk","display":"Kiluk, Brian D.","given":"Brian D.","role":"aut"},{"family":"Potenza","display":"Potenza, Marc N.","role":"aut","given":"Marc N."},{"family":"Garavan","display":"Garavan, Hugh","role":"aut","given":"Hugh"},{"display":"Chaarani, Bader","family":"Chaarani","given":"Bader","role":"aut"},{"given":"Tobias","role":"aut","family":"Banaschewski","display":"Banaschewski, Tobias"},{"display":"Bokde, Arun L. W.","family":"Bokde","given":"Arun L. W.","role":"aut"},{"role":"aut","given":"Sylvane","family":"Desrivières","display":"Desrivières, Sylvane"},{"family":"Flor","display":"Flor, Herta","role":"aut","given":"Herta"},{"role":"aut","given":"Antoine","display":"Grigis, Antoine","family":"Grigis"},{"given":"Penny","role":"aut","display":"Gowland, Penny","family":"Gowland"},{"role":"aut","given":"Andreas","display":"Heinz, Andreas","family":"Heinz"},{"role":"aut","given":"Rüdiger","family":"Brühl","display":"Brühl, Rüdiger"},{"given":"Jean-Luc","role":"aut","family":"Martinot","display":"Martinot, Jean-Luc"},{"family":"Paillère Martinot","display":"Paillère Martinot, Marie-Laure","role":"aut","given":"Marie-Laure"},{"family":"Artiges","display":"Artiges, Eric","given":"Eric","role":"aut"},{"family":"Nees","display":"Nees, Frauke","given":"Frauke","role":"aut"},{"display":"Orfanos, Dimitri Papadopoulos","family":"Orfanos","role":"aut","given":"Dimitri Papadopoulos"},{"role":"aut","given":"Luise","display":"Poustka, Luise","family":"Poustka"},{"display":"Hohmann, Sarah","family":"Hohmann","role":"aut","given":"Sarah"},{"display":"Holz, Nathalie E.","family":"Holz","role":"aut","given":"Nathalie E."},{"role":"aut","given":"Christian","family":"Baeuchl","display":"Baeuchl, Christian"},{"given":"Michael","role":"aut","family":"Smolka","display":"Smolka, Michael"},{"role":"aut","given":"Nilakshi","family":"Vaidya","display":"Vaidya, Nilakshi"},{"display":"Walter, Henrik","family":"Walter","given":"Henrik","role":"aut"},{"display":"Whelan, Robert","family":"Whelan","given":"Robert","role":"aut"},{"role":"aut","given":"Gunter","family":"Schumann","display":"Schumann, Gunter"},{"given":"Godfrey","role":"aut","family":"Pearlson","display":"Pearlson, Godfrey"},{"given":"Sarah W.","role":"aut","display":"Yip, Sarah W.","family":"Yip"}],"language":["eng"],"title":[{"title":"Identification and external validation of a problem cannabis risk network","title_sort":"Identification and external validation of a problem cannabis risk network"}],"note":["Online verfügbar: 3. Februar 2025, Artikelversion: 17. September 2025","Gesehen am 18.11.2025"],"origin":[{"dateIssuedDisp":"15 October 2025","dateIssuedKey":"2025"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1941473091","relHost":[{"part":{"extent":"11","volume":"98","pages":"586-596","year":"2025","issue":"8","text":"98(2025), 8 vom: Okt., Seite 586-596"},"language":["eng"],"id":{"zdb":["1499907-9"],"issn":["1873-2402"],"eki":["306654296"]},"recId":"306654296","physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Identification and external validation of a problem cannabis risk networkBiological psychiatry","origin":[{"dateIssuedDisp":"1985-","dateIssuedKey":"1985","publisher":"Elsevier Science","publisherPlace":"Amsterdam [u.a.]"}],"pubHistory":["Nachgewiesen 20.1985 -"],"note":["Gesehen am 08.01.20","Ungezählte Beil.: Supplement"],"title":[{"subtitle":"a journal of psychiatric neuroscience ; a publication of the Society of Biological Psychiatry","title_sort":"Biological psychiatry","title":"Biological psychiatry"}]}],"physDesc":[{"extent":"11 S.","noteIll":"Diagramme"}],"name":{"displayForm":["Sarah D. Lichenstein, Brian D. Kiluk, Marc N. Potenza, Hugh Garavan, Bader Chaarani, Tobias Banaschewski, Arun L.W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Nathalie Holz, Christian Baeuchl, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Godfrey Pearlson, and Sarah W. Yip"]},"id":{"eki":["1941473091"],"doi":["10.1016/j.biopsych.2025.01.022"]}} 
SRT |a LICHENSTEIIDENTIFICA1520 

Similar Items