Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus?: a challenging hypothesis
The hypothesis is forwarded that sporadic late-onset Alzheimer disease is caused by non-insulin dependent diabetes mellitus which is confined to the brain. This hypothesis is based on the findings of Frölich and coworkers (this volume) who clearly demonstrate a perturbation of the neuronal insulin/...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 1998
|
| In: |
Journal of neural transmission
Year: 1998, Jahrgang: 105, Heft: 4, Pages: 415-422 |
| ISSN: | 1435-1463 |
| DOI: | 10.1007/s007020050067 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s007020050067
|
| Verfasserangaben: | S. Hoyer |
| Zusammenfassung: | The hypothesis is forwarded that sporadic late-onset Alzheimer disease is caused by non-insulin dependent diabetes mellitus which is confined to the brain. This hypothesis is based on the findings of Frölich and coworkers (this volume) who clearly demonstrate a perturbation of the neuronal insulin/insulin receptor signal transduction pathway which is considered to be the pathobiochemical basis for the drastic reduction in glucose/energy metabolism in Alzheimer brain. As a consequence of this abnormality, advanced glycation end products are formed. Münch et al. (this volume) evaluate the impacts of the latter related to oxidative stress and the formation of β-amyloid and neurofibrillary tangles. |
|---|---|
| Beschreibung: | Gesehen am 20.11.2025 |
| Beschreibung: | Online Resource |
| ISSN: | 1435-1463 |
| DOI: | 10.1007/s007020050067 |