A single-cell multi-omics atlas of rice
Cell functions across eukaryotes are driven by specific gene expression programs, which are dependent on chromatin structure1-3. Here we report a single-cell multi-omics atlas of rice, one of the world’s major crops. By simultaneously profiling chromatin accessibility and RNA expression in 116,564 c...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
09 July 2025
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| In: |
Nature
Year: 2025, Jahrgang: 644, Heft: 8077, Pages: 722-730, [1-23] |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/s41586-025-09251-0 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41586-025-09251-0 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41586-025-09251-0 
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| Verfasserangaben: | Xiangyu Wang, Huanwei Huang, Sanjie Jiang, Jingmin Kang, Dongwei Li, Kailai Wang, Shang Xie, Cheng Tong, Chaofan Liu, Guihua Hu, Haoqian Li, Cong Li, Liwen Yang, Yike Ding, Shang-Tong Li, Faming Wang, Jan U. Lohmann, Zhe Liang & Xiaofeng Gu |
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| 245 | 1 | 2 | |a A single-cell multi-omics atlas of rice |c Xiangyu Wang, Huanwei Huang, Sanjie Jiang, Jingmin Kang, Dongwei Li, Kailai Wang, Shang Xie, Cheng Tong, Chaofan Liu, Guihua Hu, Haoqian Li, Cong Li, Liwen Yang, Yike Ding, Shang-Tong Li, Faming Wang, Jan U. Lohmann, Zhe Liang & Xiaofeng Gu |
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| 520 | |a Cell functions across eukaryotes are driven by specific gene expression programs, which are dependent on chromatin structure1-3. Here we report a single-cell multi-omics atlas of rice, one of the world’s major crops. By simultaneously profiling chromatin accessibility and RNA expression in 116,564 cells from eight organs, we identified cell-type-specific gene regulatory networks and described novel cell states, such as a ‘transitional state’ in floral meristems. On the basis of our network analyses, we uncovered the function of the cell-type-specific regulatory hubs RSR1, F3H and LTPL120 during rice development. Our analysis revealed correlations between cell type and agronomic traits, as well as conserved and divergent cell-type functions during evolution. In summary, this study not only offers a unique single-cell multi-omics resource for a major crop but also advances our understanding of cell-type functions and the underlying molecular programs in rice. | ||
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| 700 | 1 | |a Gu, Xiaofeng |e VerfasserIn |4 aut | |
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