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Longitudinal analysis of humoral and cellular immunity in SARS-CoV-2 exposed families

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Identification of previous SARS-CoV-2 infection typically relies on serology, yet T-cells play a key role in the adaptive immune response against SARS-CoV-2. Here, we investigated in parallel the SARS-CoV-2-specific as well as endemic human coronavirus-specific humoral and cross-reactive cellular re...

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Main Authors: Dulovic, Alex (Author) , Rabsteyn, Armin (Author) , Remppis, Jonathan (Author) , Gentzcke, Irene K. E. (Author) , Mueller, Julia (Author) , Tuecks, Nadja (Author) , Becker, Matthias (Author) , Junker, Daniel (Author) , Kaiser, Philipp D. (Author) , Traenkle, Bjoern (Author) , Rothbauer, Ulrich (Author) , Walz, Juliane S. (Author) , Peter, Andreas (Author) , Hörber, Sebastian (Author) , Ganzenmueller, Tina (Author) , Iftner, Thomas (Author) , Stich, Maximilian (Author) , Tönshoff, Burkhard (Author) , Henneke, Philipp (Author) , Elling, Roland (Author) , Debatin, Klaus-Michael (Author) , Janda, Ales (Author) , Schneiderhan-Marra, Nicole (Author) , Franz, Axel R. (Author) , Lang, Peter (Author) , Renk, Hanna (Author)
Format: Article (Journal)
Language:English
Published: 18 July 2025
In: Scientific reports
Year: 2025, Volume: 15, Pages: 1-13
ISSN:2045-2322
DOI:10.1038/s41598-025-07739-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-025-07739-3
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-025-07739-3
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Author Notes:Alex Dulovic, Armin Rabsteyn, Jonathan Remppis, Irene K.E. Gentzcke, Julia Mueller, Nadja Tuecks, Matthias Becker, Daniel Junker, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Juliane S. Walz, Andreas Peter, Sebastian Hörber, Tina Ganzenmueller, Thomas Iftner, Maximilian Stich, Burkhard Tönshoff, Philipp Henneke, Roland Elling, Klaus-Michael Debatin, Ales Janda, Nicole Schneiderhan-Marra, Axel R. Franz, Peter Lang & Hanna Renk
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Stellungnahme des "Expertenkreises Aerosole": Aerosole und SARS-CoV-2: Entstehung, Infektiosität, Ausbreitung und Minderung luftgetragener, virenhaltiger Teilchen in der Atemluft... by Brockmann, Stefan (Author) , Dittler, Achim (Author) , Grün, Gunnar (Author) , Haibel, Michael (Author) , Iftner, Thomas (Author) , Kräusslich, Hans-Georg (Author) , Mizaikoff, Boris (Author) , Niessner, Jennifer (Author) , Richter, B. (Author) , Spahn, Claudia (Author) , Stergiaropoulos, Konstantinos (Author) , Baum, Heike von (Author) ,


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Transmission of severe acute respiratory syndrome coronavirus 2 in households with children, Southwest Germany, May–August 2020 by Stich, Maximilian (Author) , Elling, Roland (Author) , Renk, Hanna (Author) , Janda, Ales̆ (Author) , Garbade, Sven (Author) , Müller, Barbara (Author) , Kräusslich, Hans-Georg (Author) , Fabricius, Dorit (Author) , Zernickel, Maria (Author) , Meissner, Peter (Author) , Huzly, Daniela (Author) , Grulich-Henn, Jürgen (Author) , Haddad, Anneke (Author) , Görne, Tessa (Author) , Spielberger, Benedikt Daniel (Author) , Fritsch, Linus (Author) , Nieters, Alexandra (Author) , Hengel, Hartmut (Author) , Dietz, Andrea N. (Author) , Stamminger, Thomas (Author) , Ganzenmüller, Tina (Author) , Ruetalo Buschinger, Natalia (Author) , Peter, Andreas (Author) , Remppis, Jonathan (Author) , Iftner, Thomas (Author) , Jeltsch, Kathrin (Author) , Waterboer, Tim (Author) , Franz, Axel Rainer (Author) , Hoffmann, Georg F. (Author) , Engel, Corinna (Author) , Debatin, Klaus-Michael (Author) , Tönshoff, Burkhard (Author) , Henneke, Philipp (Author) ,


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Long-term IL-2 therapy after transplantation of T cell depleted stem cells from alternative donors in children by Schlegel, Patrick (Author) , Teltschik, Heiko-Manuel (Author) , Pfeiffer, Matthias (Author) , Handgretinger, Rupert (Author) , Schumm, Michael (Author) , Koscielniak, Ewa (Author) , Feuchtinger, Tobias (Author) , Klingebiel, Thomas (Author) , Bader, Peter (Author) , Schlegel, Paul-Gerhardt (Author) , Greil, Johann (Author) , Lang, Peter (Author) ,


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