Treatment of systemic mastocytosis with interferon-γ: failure after appearance of anti-IFN-γ antibodies
Abstract. We report a case of a patient with systemic mastocytosis who was treated with interferon-γ. Because of severe diarrhoea, nausea and weight loss due to mast cell infiltration of the gastric mucosa the patient received 150μg d-1 interferon-γ subcutan-eously for 10 months. During therapy, the...
Gespeichert in:
| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 1995
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| In: |
European journal of clinical investigation
Year: 1995, Jahrgang: 25, Heft: 8, Pages: 615-618 |
| ISSN: | 1365-2362 |
| DOI: | 10.1111/j.1365-2362.1995.tb01754.x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1365-2362.1995.tb01754.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2362.1995.tb01754.x 
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| Verfasserangaben: | C. Fiehn, O. Prümmer, H. Gallati, B. Heilig, W. Hunstein |
MARC
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| 245 | 1 | 0 | |a Treatment of systemic mastocytosis with interferon-γ |b failure after appearance of anti-IFN-γ antibodies |c C. Fiehn, O. Prümmer, H. Gallati, B. Heilig, W. Hunstein |
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| 520 | |a Abstract. We report a case of a patient with systemic mastocytosis who was treated with interferon-γ. Because of severe diarrhoea, nausea and weight loss due to mast cell infiltration of the gastric mucosa the patient received 150μg d-1 interferon-γ subcutan-eously for 10 months. During therapy, the plasma concentrations of IL-3, IL-4 and GM-CSF, which seem to play a role in mast cell growth and differentiation were monitored. The patient had good symptomatic relief and the initially very high eosinophil counts in the pripheral blood showed a partial reduction. However, after 4 months of therapy the patient relapsed. In serum obtained after the relapse, but not in stored serum from the beginning of the therapy, neutralizing antibodies against interferon-γ were found. Therefore an initial response to the therapy and a secondary failure mediated by treatment-induced antibodies against recombinant interferon-γ might be suggested. Interferon-γ may be a well tolerated therapeutic option in systemic mastocytosis. However, treatment-induced neutralizing antibodies against recombinant interferon-γ should be considered if secondary treatment failure occurs. | ||
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| 650 | 4 | |a interferon-γ therapy | |
| 650 | 4 | |a systemic mastocytosis | |
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