Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease
Glucose metabolism in the brain has an important influence on many normal cellular processes. It contributes to the synthesis of acetylcholine, glutamate, aspartate, γ-aminobutyric acid, glycine, and ATP production (the driving force behind almost all cellular and molecular activity). Neuronal gluco...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 1996
|
| In: |
Acta neurologica Scandinavica
Year: 1996, Jahrgang: 94, Heft: S165, Pages: 18-24 |
| ISSN: | 1600-0404 |
| DOI: | 10.1111/j.1600-0404.1996.tb05868.x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1600-0404.1996.tb05868.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0404.1996.tb05868.x 
|
| Verfasserangaben: | S. Hoyer |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1942662106 | ||
| 003 | DE-627 | ||
| 005 | 20251127075423.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251127s1996 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/j.1600-0404.1996.tb05868.x |2 doi | |
| 035 | |a (DE-627)1942662106 | ||
| 035 | |a (DE-599)KXP1942662106 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hoyer, Siegfried |d 1933-2014 |e VerfasserIn |0 (DE-588)133236773 |0 (DE-627)539307343 |0 (DE-576)299715469 |4 aut | |
| 245 | 1 | 0 | |a Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease |c S. Hoyer |
| 264 | 1 | |c April 1996 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.11.2025 | ||
| 520 | |a Glucose metabolism in the brain has an important influence on many normal cellular processes. It contributes to the synthesis of acetylcholine, glutamate, aspartate, γ-aminobutyric acid, glycine, and ATP production (the driving force behind almost all cellular and molecular activity). Neuronal glucose metabolism is controlled antagonistically by insulin and cortisol. Desensitization of the neuronal insulin receptor causes abnormalities in oxidative energy metabolism. During normal aging, the cerebral energy pool is slightly diminished, but its level increases after stressful events. In age-related sporadic late-onset dementia of the Alzheimer type (SDAT), glucose metabolism and formation of cellular energy are severely reduced. Desensitization of the neuronal insulin receptor seems to be an early event in the pathogenesis or even etiology of SDAT causing disturbances in oxidative glucose metabolism and energy failure in insulin-sensitive brain structures. These abnormalities appear to induce a cascade of disturbances that leads to abnormal APP processing and amyloid formation, membrane damage, and neuronal death. | ||
| 650 | 4 | |a Alzheimer's disease | |
| 650 | 4 | |a brain | |
| 650 | 4 | |a glucose | |
| 650 | 4 | |a glucose metabolism | |
| 650 | 4 | |a insulin | |
| 650 | 4 | |a insulin receptor | |
| 650 | 4 | |a sporadic late-onset dementia of Alzheimer type | |
| 773 | 0 | 8 | |i Enthalten in |t Acta neurologica Scandinavica |d [Hoboken, NJ] : Wiley, 1961 |g 94(1996), S165, Seite 18-24 |h Online-Ressource |w (DE-627)320415740 |w (DE-600)2001898-8 |w (DE-576)091175615 |x 1600-0404 |7 nnas |a Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease |
| 773 | 1 | 8 | |g volume:94 |g year:1996 |g number:S165 |g pages:18-24 |g extent:7 |a Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease |
| 856 | 4 | 0 | |u https://doi.org/10.1111/j.1600-0404.1996.tb05868.x |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0404.1996.tb05868.x |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20251127 | ||
| 993 | |a Article | ||
| 994 | |a 1996 | ||
| 998 | |g 133236773 |a Hoyer, Siegfried |m 133236773:Hoyer, Siegfried |d 910000 |d 912000 |e 910000PH133236773 |e 912000PH133236773 |k 0/910000/ |k 1/910000/912000/ |p 1 |x j |y j | ||
| 999 | |a KXP-PPN1942662106 |e 4814710860 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 27.11.2025"],"origin":[{"dateIssuedDisp":"April 1996","dateIssuedKey":"1996"}],"title":[{"title":"Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease","title_sort":"Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"person":[{"display":"Hoyer, Siegfried","family":"Hoyer","role":"aut","given":"Siegfried"}],"relHost":[{"id":{"eki":["320415740"],"issn":["1600-0404"],"zdb":["2001898-8"],"doi":["10.1111/(ISSN)1600-0404"]},"pubHistory":["37.1961 [?]-"],"recId":"320415740","physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"note":["Gesehen am 27.01.2025","Fortsetzung der Druck-Ausgabe"],"title":[{"title_sort":"Acta neurologica Scandinavica","title":"Acta neurologica Scandinavica"}],"origin":[{"publisher":"Wiley ; Munksgaard ; Blackwell Science ; Wiley-Blackwell ; Hindawi Limited","dateIssuedKey":"2024","publisherPlace":"[Hoboken, NJ] ; Copenhagen ; Oxford ; Oxford ; London","dateIssuedDisp":"2024-"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"issue":"S165","extent":"7","volume":"94","year":"1996","pages":"18-24","text":"94(1996), S165, Seite 18-24"},"disp":"Oxidative metabolism deficiencies in brains of patients with Alzheimer's diseaseActa neurologica Scandinavica"}],"id":{"eki":["1942662106"],"doi":["10.1111/j.1600-0404.1996.tb05868.x"]},"name":{"displayForm":["S. Hoyer"]},"physDesc":[{"extent":"7 S."}],"recId":"1942662106"} | ||
| SRT | |a HOYERSIEGFOXIDATIVEM1996 | ||