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Guidelines for next-generation sequencing in sarcoma diagnosis and treatment: a consensus review

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Sarcomas comprise a heterogeneous group of malignant neoplasms that include genomically simple (driven by recurrent genetic alterations) and genomically complex (characterized by extensive genomic rearrangements) subtypes. Regardless, sarcomas exhibit a remarkably low mutational burden. In this cont...

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Main Authors: Serrano, César (Author) , Bauer, Sebastian (Author) , Blay, Jean-Yves (Author) , Casali, Paolo G. (Author) , Cicala, Carlo M. (Author) , Dei Tos, Angelo P. (Author) , Digklia, Antonia (Author) , Gelderblom, Hans (Author) , Italiano, Antoine (Author) , Jones, Robin L. (Author) , Kasper, Bernd (Author) , Kyriazoglou, Anastasios (Author) , Le Loarer, Francois (Author) , Martín-Broto, Javier (Author) , Napolitano, Andrea (Author) , Rutkowski, Piotr (Author) , Stacchiotti, Silvia (Author) , Tap, William (Author) , Thomas, David (Author) , Thway, Khin (Author) , Valverde, Claudia (Author) , van der Graaf, Winette T. A. (Author) , Wardelmann, Eva (Author) , Bovée, Judith V. M. G. (Author)
Format: Article (Journal)
Language:English
Published: October 16, 2025
In: JAMA oncology

ISSN:2374-2445
DOI:10.1001/jamaoncol.2025.3608
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1001/jamaoncol.2025.3608
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Author Notes:César Serrano, MD, PhD, Sebastian Bauer, MD, Jean-Yves Blay, MD, PhD, Paolo G. Casali, MD, PhD, Carlo M. Cicala, MD, Angelo P. Dei Tos, MD, PhD, Antonia Digklia, MD, Hans Gelderblom, MD, Antoine Italiano, MD, PhD, Robin L. Jones, MD, Bernd Kasper, MD, Anastasios Kyriazoglou, MD, PhD, Francois Le Loarer, MD, Javier Martín-Broto, MD, PhD, Andrea Napolitano, MD, Piotr Rutkowski, MD, Silvia Stacchiotti, MD, William Tap, MD, David Thomas, MD, PhD, Khin Thway, MD, Claudia Valverde, MD, PhD, Winette T.A. van der Graaf, MD, Eva Wardelmann, MD, Judith V.M.G. Bovée, MD, PhD
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Guidelines for next-generation sequencing in sarcoma diagnosis and treatment: a consensus review by Serrano, César (Author) , Bauer, Sebastian (Author) , Blay, Jean-Yves (Author) , Casali, Paolo G. (Author) , Cicala, Carlo M. (Author) , Dei Tos, Angelo P. (Author) , Digklia, Antonia (Author) , Gelderblom, Hans (Author) , Italiano, Antoine (Author) , Jones, Robin L. (Author) , Kasper, Bernd (Author) , Kyriazoglou, Anastasios (Author) , Le Loarer, Francois (Author) , Martin-Broto, Javier (Author) , Napolitano, Andrea (Author) , Rutkowski, Piotr (Author) , Stacchiotti, Silvia (Author) , Tap, William D. (Author) , Thomas, David (Author) , Thway, Khin (Author) , Valverde, Claudia (Author) , van der Graaf, Winette T. A. (Author) , Wardelmann, Eva (Author) , Bovée, Judith V. M. G. (Author) ,


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