Sinonasal sarcomas management: an international consensus statement
Introduction Sinonasal sarcomas are exceedingly rare entities, constituting less than 7% of head and neck sarcomas. Their complex histology needs specialized treatment, which is often based on multimodal approaches including surgery, radiation therapy, and/or chemotherapy. This manuscript aims to ga...
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2025
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| In: |
International forum of allergy & rhinology
Year: 2025, Pages: 1-15 |
| ISSN: | 2042-6984 |
| DOI: | 10.1002/alr.70038 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/alr.70038 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/alr.70038 
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| Verfasserangaben: | Alessandro Vinciguerra, Francesca Caspani, Marco Valentini, Anna Maria Camarda, Salvatore Provenzano, Eric W. Wang, Cem Meço, Marco Ferrari, Pavol Surda, Semi Harrabi, Fernando Augusto Batista Campos, Javier Martin Broto, B. Ashleigh Guadagnolo, Pierina Navarria, Ali Hosni, Nadia Hindi, Antoine Italiano, Daniel M. Trifiletti, Bernd Kasper, Benjamin Verillaud, Alberto Schreiber, Paolo Castelnuovo, Piero Nicolai, Iacopo Dallan, Matias Chacon, Shirley Y. Su, Juliette Thariat, Claudia Valverde, Matt Lechner, Jean Yves Blay, Maria Rosaria Fiore, Jean Anderson Eloy, Mehdi Brahmi, James N. Palmer, Victor Castro Oliden, Daniela Greto, Iwona Lugowska, Angelo Paolo Dei Tos, Thibaut van Zele, Alkis J. Psaltis, Paolo Giovanni Casali, Armelle Dufresne, Claudia Sangalli, Christos Georgalas, Ester Orlandi, Peter-John Wormald, Philippe Herman, Ricardo Carrau, Ehab Y. Hanna, Lisa Licitra, Mario Turri-Zanoni, Paolo Battaglia |
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| 245 | 1 | 0 | |a Sinonasal sarcomas management |b an international consensus statement |c Alessandro Vinciguerra, Francesca Caspani, Marco Valentini, Anna Maria Camarda, Salvatore Provenzano, Eric W. Wang, Cem Meço, Marco Ferrari, Pavol Surda, Semi Harrabi, Fernando Augusto Batista Campos, Javier Martin Broto, B. Ashleigh Guadagnolo, Pierina Navarria, Ali Hosni, Nadia Hindi, Antoine Italiano, Daniel M. Trifiletti, Bernd Kasper, Benjamin Verillaud, Alberto Schreiber, Paolo Castelnuovo, Piero Nicolai, Iacopo Dallan, Matias Chacon, Shirley Y. Su, Juliette Thariat, Claudia Valverde, Matt Lechner, Jean Yves Blay, Maria Rosaria Fiore, Jean Anderson Eloy, Mehdi Brahmi, James N. Palmer, Victor Castro Oliden, Daniela Greto, Iwona Lugowska, Angelo Paolo Dei Tos, Thibaut van Zele, Alkis J. Psaltis, Paolo Giovanni Casali, Armelle Dufresne, Claudia Sangalli, Christos Georgalas, Ester Orlandi, Peter-John Wormald, Philippe Herman, Ricardo Carrau, Ehab Y. Hanna, Lisa Licitra, Mario Turri-Zanoni, Paolo Battaglia |
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| 500 | |a Erstmals veröffentlicht: 30. September 2025 | ||
| 500 | |a Gesehen am 27.11.2025 | ||
| 520 | |a Introduction Sinonasal sarcomas are exceedingly rare entities, constituting less than 7% of head and neck sarcomas. Their complex histology needs specialized treatment, which is often based on multimodal approaches including surgery, radiation therapy, and/or chemotherapy. This manuscript aims to gather expert opinions to establish common management principles for sinonasal sarcomas. Methods This international consensus followed a modified Delphi method in seven steps, including statements definition by the core group, expert panel recruitment, and a two-round survey. Sixty-two statements on sinonasal sarcoma management were developed. Experts from multiple continents participated, and results were anonymized and analyzed between March and May 2025. Results A total of 44 invited experts were recruited, 43.2% otorhinolaryngologists/head and neck surgeons, 31.8% medical oncologists, and 25% radiation oncologists. Participants varied in age and experience, representing Europe (70.5%), North America (18.2%), South America (6.8%), and Asia (4.5%). Among all histologies, biphenotypic sarcoma, chondrosarcoma, leiomyosarcoma, and myofibrosarcoma are principally treated with an upfront surgical management, differently from Ewing sarcoma and rhabdomyosarcoma in which chemotherapy, eventually associated with radiotherapy, is often chosen. In the remaining histologies (angiosarcoma, liposarcoma, malignant peripheral nerve sheath tumor [MPNST], osteosarcoma, and synovial sarcoma), a precise multimodal treatment is less standardized and needs to be discussed on a case-by-case basis. Conclusion Sinonasal sarcomas require a histology-driven approach to determine upfront treatment, whether surgical, medical, or multimodal. Despite this structured strategy, prognosis remains highly variable across subtypes. Multidisciplinary evaluation and individualized management in referral centers are crucial to address the biological diversity and anatomical complexity of these rare malignancies. | ||
| 650 | 4 | |a angiosarcoma | |
| 650 | 4 | |a biphenotypic sinonasal sarcoma | |
| 650 | 4 | |a chondrosarcoma | |
| 650 | 4 | |a Ewing sarcoma | |
| 650 | 4 | |a leiomyosarcoma | |
| 650 | 4 | |a malignant peripheral nerve sheath tumor | |
| 650 | 4 | |a osteosarcoma | |
| 650 | 4 | |a rhabdomyosarcoma | |
| 650 | 4 | |a sinonasal sarcomas | |
| 650 | 4 | |a synovial sarcoma | |
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| 700 | 1 | |a Ferrari, Marco |e VerfasserIn |4 aut | |
| 700 | 1 | |a Surda, Pavol |e VerfasserIn |4 aut | |
| 700 | 1 | |a Harrabi, Semi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Campos, Fernando Augusto Batista |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Fiore, Maria Rosaria |e VerfasserIn |4 aut | |
| 700 | 1 | |a Eloy, Jean Anderson |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brahmi, Mehdi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Palmer, James N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Oliden, Victor Castro |e VerfasserIn |4 aut | |
| 700 | 1 | |a Greto, Daniela |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lugowska, Iwona |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tos, Angelo Paolo Dei |e VerfasserIn |4 aut | |
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