Mesenchymal stem cells: a therapeutic approach in fertility restoration in premature ovarian insufficiency
Primary ovarian insufficiency (POI) represents the cessation of ovarian function before age 40 due to follicular depletion or dysfunction. Affecting 1% of women, POI causes infertility and systemic health complications. Current treatments focus on symptom management rather than restoring ovarian fun...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2025
|
| In: |
Stem cell reviews and reports
Year: 2025, Jahrgang: 21, Heft: 7, Pages: 2089-2102 |
| ISSN: | 2629-3277 |
| DOI: | 10.1007/s12015-025-10944-2 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s12015-025-10944-2 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s12015-025-10944-2 
|
| Verfasserangaben: | Nourhan Hassan, Donia Mohamed Hussein, Fady Ashraf Malak, Mazen Ashraf Abdelaziz, Michael Ibrahim Boushra, Walid Shaalan, Emad M. Elzayat |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1942697856 | ||
| 003 | DE-627 | ||
| 005 | 20251127115529.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251127s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s12015-025-10944-2 |2 doi | |
| 035 | |a (DE-627)1942697856 | ||
| 035 | |a (DE-599)KXP1942697856 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Hassan, Nourhan |d 1990- |e VerfasserIn |0 (DE-588)1291314725 |0 (DE-627)1847173519 |4 aut | |
| 245 | 1 | 0 | |a Mesenchymal stem cells |b a therapeutic approach in fertility restoration in premature ovarian insufficiency |c Nourhan Hassan, Donia Mohamed Hussein, Fady Ashraf Malak, Mazen Ashraf Abdelaziz, Michael Ibrahim Boushra, Walid Shaalan, Emad M. Elzayat |
| 264 | 1 | |c October 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 01. August 2025 | ||
| 500 | |a Gesehen am 27.11.2025 | ||
| 520 | |a Primary ovarian insufficiency (POI) represents the cessation of ovarian function before age 40 due to follicular depletion or dysfunction. Affecting 1% of women, POI causes infertility and systemic health complications. Current treatments focus on symptom management rather than restoring ovarian function. Mesenchymal stem cells (MSCs) offer promising regenerative potential through paracrine activity, immunomodulation, and tissue repair mechanisms. MSCs from various sources have demonstrated the ability to improve ovarian function, increase follicular survival, and restore hormone production in preclinical models. MSC-derived extracellular vesicles are emerging as cell-free alternatives with similar therapeutic effects. This review examines MSC mechanisms in ovarian restoration, evaluates current evidence, and discusses challenges in clinical translation for POI treatment. | ||
| 650 | 4 | |a Exosomes | |
| 650 | 4 | |a Extracellular vesicles | |
| 650 | 4 | |a Fertility restoration | |
| 650 | 4 | |a Mesenchymal stem cells | |
| 650 | 4 | |a Ovarian rejuvenation | |
| 650 | 4 | |a Premature ovarian dysfunction | |
| 650 | 4 | |a Regenerative medicine | |
| 700 | 1 | |a Hussein, Donia Mohamed |e VerfasserIn |4 aut | |
| 700 | 1 | |a Malak, Fady Ashraf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Abdelaziz, Mazen Ashraf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Boushra, Michael Ibrahim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Shaalan, Walid |d 1983- |e VerfasserIn |0 (DE-588)1219028452 |0 (DE-627)1734680148 |4 aut | |
| 700 | 1 | |a Elzayat, Emad M. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Stem cell reviews and reports |d New York, NY : Springer, 2009 |g 21(2025), 7, Seite 2089-2102 |h Online-Ressource |w (DE-627)600310051 |w (DE-600)2495579-6 |w (DE-576)33496783X |x 2629-3277 |7 nnas |a Mesenchymal stem cells a therapeutic approach in fertility restoration in premature ovarian insufficiency |
| 773 | 1 | 8 | |g volume:21 |g year:2025 |g number:7 |g pages:2089-2102 |g extent:14 |a Mesenchymal stem cells a therapeutic approach in fertility restoration in premature ovarian insufficiency |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s12015-025-10944-2 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007/s12015-025-10944-2 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20251127 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1219028452 |a Shaalan, Walid |m 1219028452:Shaalan, Walid |d 910000 |d 910400 |e 910000PS1219028452 |e 910400PS1219028452 |k 0/910000/ |k 1/910000/910400/ |p 6 | ||
| 999 | |a KXP-PPN1942697856 |e 4814791739 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1942697856","language":["eng"],"note":["Online verfügbar: 01. August 2025","Gesehen am 27.11.2025"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Mesenchymal stem cells","title":"Mesenchymal stem cells","subtitle":"a therapeutic approach in fertility restoration in premature ovarian insufficiency"}],"person":[{"display":"Hassan, Nourhan","roleDisplay":"VerfasserIn","role":"aut","family":"Hassan","given":"Nourhan"},{"family":"Hussein","given":"Donia Mohamed","display":"Hussein, Donia Mohamed","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Malak","given":"Fady Ashraf","display":"Malak, Fady Ashraf","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Mazen Ashraf","family":"Abdelaziz","role":"aut","display":"Abdelaziz, Mazen Ashraf","roleDisplay":"VerfasserIn"},{"given":"Michael Ibrahim","family":"Boushra","role":"aut","roleDisplay":"VerfasserIn","display":"Boushra, Michael Ibrahim"},{"family":"Shaalan","given":"Walid","roleDisplay":"VerfasserIn","display":"Shaalan, Walid","role":"aut"},{"role":"aut","display":"Elzayat, Emad M.","roleDisplay":"VerfasserIn","given":"Emad M.","family":"Elzayat"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["2629-3277"],"eki":["600310051"],"zdb":["2495579-6"]},"origin":[{"publisher":"Springer ; Humana Press","dateIssuedKey":"2009","dateIssuedDisp":"2009-","publisherPlace":"New York, NY ; New York, NY"}],"language":["eng"],"recId":"600310051","disp":"Mesenchymal stem cells a therapeutic approach in fertility restoration in premature ovarian insufficiencyStem cell reviews and reports","note":["Gesehen am 24.01.14"],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"extent":"14","text":"21(2025), 7, Seite 2089-2102","volume":"21","pages":"2089-2102","issue":"7","year":"2025"},"pubHistory":["5.2009 -"],"title":[{"title_sort":"Stem cell reviews and reports","title":"Stem cell reviews and reports"}]}],"physDesc":[{"noteIll":"Illustrationen","extent":"14 S."}],"id":{"eki":["1942697856"],"doi":["10.1007/s12015-025-10944-2"]},"origin":[{"dateIssuedDisp":"October 2025","dateIssuedKey":"2025"}],"name":{"displayForm":["Nourhan Hassan, Donia Mohamed Hussein, Fady Ashraf Malak, Mazen Ashraf Abdelaziz, Michael Ibrahim Boushra, Walid Shaalan, Emad M. Elzayat"]}} | ||
| SRT | |a HASSANNOURMESENCHYMA2025 | ||