Cover Image

Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load

It was recently demonstrated that IL-8 is produced by melanoma cell lines and acts as an essential autocrine growth factor. We studied the constitutive production of IL-8 by melanoma cell lines and the serum concentrations in patients with metastatic melanoma. All of 10 melanoma cell lines investiga...

Full description

Saved in:
Bibliographic Details
Main Authors: Scheibenbogen, Carmen (Author) , Möhler, Thomas (Author) , Haefele, Joachim (Author) , Hunstein, Werner (Author) , Keilholz, Ulrich (Author)
Format: Article (Journal)
Language:English
Published: June 1995
In: Melanoma research
Year: 1995, Volume: 5, Issue: 3, Pages: 179-182
ISSN:1473-5636
DOI:10.1097/00008390-199506000-00006
Online Access:Verlag: https://doi.org/10.1097/00008390-199506000-00006
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/melanomaresearch/abstract/1995/06000/serum_interleukin_8__il_8__is_elevated_in_patients.6.aspx
Get full text
Author Notes:C. Scheibenbogen, T. Möhler, J. Haefele, W. Hunstein, U. Keilholz

MARC

LEADER 00000naa a2200000 c 4500
001 1942698232
003 DE-627
005 20251127120208.0
007 cr uuu---uuuuu
008 251127s1995 xx |||||o 00| ||eng c
024 7 |a 10.1097/00008390-199506000-00006  |2 doi 
035 |a (DE-627)1942698232 
035 |a (DE-599)KXP1942698232 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Scheibenbogen, Carmen  |d 1962-  |e VerfasserIn  |0 (DE-588)1108128629  |0 (DE-627)863747442  |0 (DE-576)176760598  |4 aut 
245 1 0 |a Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load  |c C. Scheibenbogen, T. Möhler, J. Haefele, W. Hunstein, U. Keilholz 
264 1 |c June 1995 
300 |a 4 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 27.11.2025 
520 |a It was recently demonstrated that IL-8 is produced by melanoma cell lines and acts as an essential autocrine growth factor. We studied the constitutive production of IL-8 by melanoma cell lines and the serum concentrations in patients with metastatic melanoma. All of 10 melanoma cell lines investigated constitutively produced IL-8 (mean 315 ± 58 pg/10s cells per 24 h. IL-8 was detectable (mean 159 ± 13.1 pg/ml) in the serum of 21 out of 56 patients by an enzyme-linked immunosorbent assay (ELISA; detection limit < 100 pg/ml). There was a significant correlation with tumour load, whereas no correlation with metastatic sites was found. No increased IL-8 levels were seen in healthy controls or patients with metastatic renal cell carcinoma. These results suggest that IL-8 is constitutively produced by melanoma cells in vivo. 
700 1 |a Möhler, Thomas  |e VerfasserIn  |0 (DE-588)1014877261  |0 (DE-627)705298051  |0 (DE-576)34979572X  |4 aut 
700 1 |a Haefele, Joachim  |d 1968-  |e VerfasserIn  |0 (DE-588)118031104  |0 (DE-627)694611913  |0 (DE-576)29167710X  |4 aut 
700 1 |a Hunstein, Werner  |d 1928-2012  |e VerfasserIn  |0 (DE-588)1012782662  |0 (DE-627)699775833  |0 (DE-576)345935667  |4 aut 
700 1 |a Keilholz, Ulrich  |e VerfasserIn  |0 (DE-588)111152324X  |0 (DE-627)865593043  |0 (DE-576)161675387  |4 aut 
773 0 8 |i Enthalten in  |t Melanoma research  |d Hagerstown, Md. : Lippincott Williams & Wilkins, 1991  |g 5(1995), 3, Seite 179-182  |h Online-Ressource  |w (DE-627)324822308  |w (DE-600)2030780-9  |w (DE-576)09629065X  |x 1473-5636  |7 nnas  |a Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load 
773 1 8 |g volume:5  |g year:1995  |g number:3  |g pages:179-182  |g extent:4  |a Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load 
856 4 0 |u https://doi.org/10.1097/00008390-199506000-00006  |x Verlag 
856 4 0 |u https://journals.lww.com/melanomaresearch/abstract/1995/06000/serum_interleukin_8__il_8__is_elevated_in_patients.6.aspx  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20251127 
993 |a Article 
994 |a 1995 
998 |g 111152324X  |a Keilholz, Ulrich  |m 111152324X:Keilholz, Ulrich  |d 910000  |d 910100  |e 910000PK111152324X  |e 910100PK111152324X  |k 0/910000/  |k 1/910000/910100/  |p 5  |y j 
998 |g 1012782662  |a Hunstein, Werner  |m 1012782662:Hunstein, Werner  |d 910000  |d 910100  |e 910000PH1012782662  |e 910100PH1012782662  |k 0/910000/  |k 1/910000/910100/  |p 4 
998 |g 118031104  |a Haefele, Joachim  |m 118031104:Haefele, Joachim  |d 50000  |e 50000PH118031104  |k 0/50000/  |p 3 
998 |g 1014877261  |a Möhler, Thomas  |m 1014877261:Möhler, Thomas  |d 910000  |d 910100  |e 910000PM1014877261  |e 910100PM1014877261  |k 0/910000/  |k 1/910000/910100/  |p 2 
998 |g 1108128629  |a Scheibenbogen, Carmen  |m 1108128629:Scheibenbogen, Carmen  |d 910000  |d 910100  |e 910000PS1108128629  |e 910100PS1108128629  |k 0/910000/  |k 1/910000/910100/  |p 1  |x j 
999 |a KXP-PPN1942698232  |e 4814793219 
BIB |a Y 
SER |a journal 
JSO |a {"id":{"eki":["1942698232"],"doi":["10.1097/00008390-199506000-00006"]},"origin":[{"dateIssuedDisp":"June 1995","dateIssuedKey":"1995"}],"name":{"displayForm":["C. Scheibenbogen, T. Möhler, J. Haefele, W. Hunstein, U. Keilholz"]},"relHost":[{"title":[{"subtitle":"an international journal for rapid communication of basic and clinical research in melanoma","title":"Melanoma research","title_sort":"Melanoma research"}],"recId":"324822308","language":["eng"],"note":["Gesehen am 28.05.19"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour loadMelanoma research","part":{"year":"1995","issue":"3","pages":"179-182","volume":"5","text":"5(1995), 3, Seite 179-182","extent":"4"},"pubHistory":["1.1991 -"],"id":{"eki":["324822308"],"zdb":["2030780-9"],"issn":["1473-5636"]},"origin":[{"publisherPlace":"Hagerstown, Md. ; [Erscheinungsort nicht ermittelbar]","dateIssuedDisp":"1991-","dateIssuedKey":"1991","publisher":"Lippincott Williams & Wilkins ; Ovid"}],"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"4 S."}],"title":[{"title":"Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load","title_sort":"Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load"}],"person":[{"family":"Scheibenbogen","given":"Carmen","roleDisplay":"VerfasserIn","display":"Scheibenbogen, Carmen","role":"aut"},{"given":"Thomas","family":"Möhler","role":"aut","roleDisplay":"VerfasserIn","display":"Möhler, Thomas"},{"family":"Haefele","given":"Joachim","roleDisplay":"VerfasserIn","display":"Haefele, Joachim","role":"aut"},{"role":"aut","display":"Hunstein, Werner","roleDisplay":"VerfasserIn","given":"Werner","family":"Hunstein"},{"family":"Keilholz","given":"Ulrich","display":"Keilholz, Ulrich","roleDisplay":"VerfasserIn","role":"aut"}],"language":["eng"],"recId":"1942698232","note":["Gesehen am 27.11.2025"],"type":{"media":"Online-Ressource","bibl":"article-journal"}} 
SRT |a SCHEIBENBOSERUMINTER1995 

Similar Items