How to protect the proximal bronchial tree during stereotactic radiotherapy of ultracentral lung tumors: Lessons from MR-guided treatment
Purpose - To use imaging data from stereotactic MR-guided online adaptive radiotherapy (SMART) of ultracentral lung tumors (ULT) for development of a safe non-adaptive approach towards stereotactic body radiotherapy (SBRT) of ULT. - Patients and Methods - Analysis is based on 19 patients with ULT wh...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 2025
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| In: |
Clinical and translational radiation oncology
Year: 2025, Jahrgang: 51, Pages: 1-6 |
| ISSN: | 2405-6308 |
| DOI: | 10.1016/j.ctro.2024.100899 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ctro.2024.100899 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2405630824001769 
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| Verfasserangaben: | Sebastian Regnery, Efthimios Katsigiannopulos, Hin Lau, Philipp Hoegen-Saßmannshausen, Fabian Weykamp, Claudia Katharina Renkamp, Carolin Rippke, Fabian Schlüter, Sophia Albert, Jan Meis, Marietta Kirchner, Alexandra Balzer, Nicolaus Andratschke, Matthias Guckenberger, Jürgen Debus, Sebastian Klüter, Juliane Hörner-Rieber |
| Zusammenfassung: | Purpose - To use imaging data from stereotactic MR-guided online adaptive radiotherapy (SMART) of ultracentral lung tumors (ULT) for development of a safe non-adaptive approach towards stereotactic body radiotherapy (SBRT) of ULT. - Patients and Methods - Analysis is based on 19 patients with ULT who received SMART (10 × 5.0-5.5 Gy) on a 0.35 T MR-Linac (MRIdian®) in the prospective MAGELLAN trial. 4D-planning CT data of six patients served to quantify proximal bronchial tree (PBT) breathing motion. Daily fraction MRIs are used to calculate interfractional translations (mediolateral (ML), anterior-posterior (AP), superior-inferior (SI)) and their dosimetric consequences for the PBT. A planning risk volume (PRV) is calculated for an assumed non-adaptive SBRT in deep-inspiration breath hold (DIBH) with surface-guidance (AlignRT®). Finally, non-adaptive volumetric modulated arc (VMAT) SBRT is simulated with and without a PRV for N = 10 patients (10 × 5.5 Gy). - Results - The PBT shows relevant breathing motion, especially in superior-inferior direction (median ML: 2.5 mm, AP: 1.9 mm and SI: 9.2 mm). Furthermore, moderate interfractional translations are observed (mean absolute translation ML: 1.3 mm, AP: 1.3 mm, SI: 1.1 mm), with an estimated 2 mm PRV margin for interfractional changes alone. Simulated non-adaptive SBRT leads to PBT overdoses in 60 % of patients (median overdosed fractions VMAT: 2.5, predicted MR-linac plans 4). Both MR-guided online plan adaptation (SMART) and PRV-based non-adaptive VMAT prevent PBT overdoses, but SMART yields significantly higher planning target volume (PTV) coverage (SMART: median 96 % [IQR 95-96], VMAT: median 89 % [IQR 77-94], p = 0.014). - Conclusions - Both intrafractional breathing motion and interfractional translations may impact doses to the PBT during SBRT of ULT. SMART protects the PBT from overdoses while maintaining high PTV coverage. Non-adaptive SBRT appears safe with advanced breathing motion management and PRV, but yields inferior PTV coverage. |
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| Beschreibung: | Gesehen am 27.11.2025 Online veröffentlicht: 7. Dezember 2024 |
| Beschreibung: | Online Resource |
| ISSN: | 2405-6308 |
| DOI: | 10.1016/j.ctro.2024.100899 |