DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts
CD4+ regulatory T (Treg) cells in tissues play crucial immunoregulatory and regenerative roles. Despite their importance, the epigenetics and differentiation of human tissue Treg cells are incompletely understood. Here, we performed genome-wide DNA methylation analysis of human Treg cells from skin...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
16 July 2025
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| In: |
Nature immunology
Year: 2025, Volume: 26, Issue: 8, Pages: 1315-1328 |
| ISSN: | 1529-2916 |
| DOI: | 10.1038/s41590-025-02210-x |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41590-025-02210-x Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41590-025-02210-x 
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| Author Notes: | Niklas Beumer, Charles D. Imbusch, Tamara Kaufmann, Lisa Schmidleithner, Kathrin Gütter, Philipp Stüve, Harriet Marchel, Dieter Weichenhan, Marion Bähr, Brigitte Ruhland, Federico Marini, Lieke Sanderink, Uwe Ritter, Malte Simon, Kathrin Luise Braband, Morten Michael Voss, Sara Salome Helbich, Delia Mihaela Mihoc, Agnes Hotz-Wagenblatt, Hadrian Nassabi, Andreas Eigenberger, Lukas Prantl, Claudia Gebhard, Michael Rehli, Nicholas Strieder, Kartikeya Singh, Christian Schmidl, Christoph Plass, Jochen Huehn, Thomas Hehlgans, Julia K. Polansky, Benedikt Brors, Michael Delacher & Markus Feuerer |
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| 245 | 1 | 0 | |a DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts |c Niklas Beumer, Charles D. Imbusch, Tamara Kaufmann, Lisa Schmidleithner, Kathrin Gütter, Philipp Stüve, Harriet Marchel, Dieter Weichenhan, Marion Bähr, Brigitte Ruhland, Federico Marini, Lieke Sanderink, Uwe Ritter, Malte Simon, Kathrin Luise Braband, Morten Michael Voss, Sara Salome Helbich, Delia Mihaela Mihoc, Agnes Hotz-Wagenblatt, Hadrian Nassabi, Andreas Eigenberger, Lukas Prantl, Claudia Gebhard, Michael Rehli, Nicholas Strieder, Kartikeya Singh, Christian Schmidl, Christoph Plass, Jochen Huehn, Thomas Hehlgans, Julia K. Polansky, Benedikt Brors, Michael Delacher & Markus Feuerer |
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| 520 | |a CD4+ regulatory T (Treg) cells in tissues play crucial immunoregulatory and regenerative roles. Despite their importance, the epigenetics and differentiation of human tissue Treg cells are incompletely understood. Here, we performed genome-wide DNA methylation analysis of human Treg cells from skin and blood and integrated these data into a multiomic framework, including chromatin accessibility and gene expression. This analysis identified programs that governed the tissue adaptation of skin Treg cells. We found that subfamilies of transposable elements represented a major constituent of the hypomethylated landscape in tissue Treg cells. Based on T cell antigen receptor sequence and DNA hypomethylation homologies, our data indicate that blood CCR8+ Treg cells contain recirculating human skin Treg cells. Conversely, differences in chromatin accessibility and gene expression suggest a certain reversal of the tissue adaptation program during recirculation. Our findings provide insights into the biology of human tissue Treg cells, which may help harness these cells for therapeutic purposes. | ||
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