A novel complex of membrane proteins required for formation of a spherical nucleus
Two membrane proteins were identified through their genetic interaction with the nucleoporin Nup84p and shown to participate in nuclear envelope morphogenesis in yeast. One component is a known sporulation factor Spo7p, and the other, Nem1p, a novel protein whose C‐terminal domain is conserved durin...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 16, 1998
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| In: |
The EMBO journal
Year: 1998, Jahrgang: 17, Heft: 22, Pages: 6449-6464 |
| ISSN: | 1460-2075 |
| DOI: | 10.1093/emboj/17.22.6449 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/emboj/17.22.6449 Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.1093/emboj/17.22.6449 
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| Verfasserangaben: | Symeon Siniossoglou, Helena Santos‐Rosa, Juri Rappsilber, Mathias Mann, Ed Hurt |
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| 245 | 1 | 2 | |a A novel complex of membrane proteins required for formation of a spherical nucleus |c Symeon Siniossoglou, Helena Santos‐Rosa, Juri Rappsilber, Mathias Mann, Ed Hurt |
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| 520 | |a Two membrane proteins were identified through their genetic interaction with the nucleoporin Nup84p and shown to participate in nuclear envelope morphogenesis in yeast. One component is a known sporulation factor Spo7p, and the other, Nem1p, a novel protein whose C‐terminal domain is conserved during eukaryotic evolution. Spo7p and Nem1p localize to the nuclear/ER membrane and behave biochemically as integral membrane proteins. Nem1p binds to Spo7p via its conserved C‐terminal domain. Although cells without Spo7p or Nem1p are viable, they exhibit a drastically altered nuclear morphology with long, pore‐containing double nuclear membrane extensions. These protrusions emanate from a core nucleus which contains the DNA, and penetrate deeply into the cytoplasm. Interestingly, not only Spo7− and Nem1−, but also several nucleoporin mutants are defective in sporulation. Thus, Spo7p and Nem1p, which exhibit a strong genetic link to nucleoporins of the Nup84p complex, fulfil an essential role in formation of a spherical nucleus and meiotic division. | ||
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| 650 | 4 | |a nuclear envelope | |
| 650 | 4 | |a nuclear morphology | |
| 650 | 4 | |a nuclear pore complex | |
| 650 | 4 | |a sporulation | |
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