Spectral attenuation curves of photon-counting detector CT scans for the differentiation between mucinous and non-mucinous cyst fluids of pancreatic lesions: a proof-of-concept study
Abstract - - Background - Spectral imaging via photon-counting detector CT (PCD-CT) scanners allows the generation of spectral attenuation curves. Our study aimed to test the feasibility of spectral attenuation curve analysis for differentiating mucinous from...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
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01 July 2025
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| In: |
BMC medical imaging
Year: 2025, Jahrgang: 25, Pages: 1-12 |
| ISSN: | 1471-2342 |
| DOI: | 10.1186/s12880-025-01770-6 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12880-025-01770-6 Verlag, kostenfrei, Volltext: https://bmcmedimaging.biomedcentral.com/articles/10.1186/s12880-025-01770-6 
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| Verfasserangaben: | Ibolyka Dudás, Borbála Lovász, Márton Benke, Máté Kiss, Markus Juergens, Ákos Szücs, Pál N. Kaposi, Attila Szijártó, Pál Maurovich-Horvat and Bettina K. Budai |
MARC
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| 245 | 1 | 0 | |a Spectral attenuation curves of photon-counting detector CT scans for the differentiation between mucinous and non-mucinous cyst fluids of pancreatic lesions |b a proof-of-concept study |c Ibolyka Dudás, Borbála Lovász, Márton Benke, Máté Kiss, Markus Juergens, Ákos Szücs, Pál N. Kaposi, Attila Szijártó, Pál Maurovich-Horvat and Bettina K. Budai |
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| 520 | |a Abstract - - Background - Spectral imaging via photon-counting detector CT (PCD-CT) scanners allows the generation of spectral attenuation curves. Our study aimed to test the feasibility of spectral attenuation curve analysis for differentiating mucinous from non-mucinous cyst fluids of pancreatic cystic lesions (PCL). - - - Methods - - Our study included 74 patients with PCLs. The classic morphological features were evaluated by an expert radiologist. The spectral attenuation curves were generated from the pancreatic-phase scans. The average CT values were measured on the 70 keV (HU - 70keV - ) and 40 keV (HU - 40keV - ) virtual monoenergetic images (VMIs), and the differences were calculated (HU - Δ40−70keV - ). The cases were divided into training (53 mucinous vs. 19 non-mucinous PCLs) and test (10 mucinous vs. 10 non-mucinous PCLs) datasets. The receiver operating characteristic (ROC) curve analysis assessed the discrimination performance. The intra- and interobserver reproducibilities were evaluated by the intraclass correlation coefficient (ICC). - - - - Results - - On 70 keV VMIs, no significant differences were found between the average CT values of mucinous and non-mucinous PCLs, however, the difference was significant in HU - Δ40−70keV - values ( - p - < 0.0001). The diagnostic performance of HU - Δ40−70keV - in differentiating between mucinous vs. non-mucinous PCL had AUCs of 0.92 and 0.92 on the training and test datasets, respectively, with a good interobserver (ICC = 0.82) and excellent intraobserver reproducibility (ICC = 0.94). The conventional clinical-radiological model achieved AUCs of 0.85 and 0.86, and with the addition of HU - Δ40−70keV - values its performance increased significantly to 0.98 and 0.94 on the training and test datasets, respectively. - - - - Conclusions - Spectral attenuation curve assessment of cyst fluids could be a useful additional measurement to facilitate the noninvasive differential diagnosis of PCLs. | ||
| 700 | 1 | |a Lovász, Borbála |e VerfasserIn |4 aut | |
| 700 | 1 | |a Benke, Márton |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kiss, Máté |e VerfasserIn |4 aut | |
| 700 | 1 | |a Juergens, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Szücs, Ákos |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kaposi, Pál N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Szijártó, Attila |e VerfasserIn |4 aut | |
| 700 | 1 | |a Maurovich-Horvat, Pál |e VerfasserIn |4 aut | |
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