Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed mice
Metabolic dysfunction associated steatotic liver disease (MASLD) presents a growing global health problem. Disease progression is promoted not only by hepatic leukocyte accumulation but also by inflammatory signals from adipose tissue and an altered gut microbiome. To determine the contribution of i...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 July 2025
|
| In: |
Scientific reports
Year: 2025, Jahrgang: 15, Pages: 1-14 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-025-11555-0 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-025-11555-0 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-025-11555-0 
|
| Verfasserangaben: | Sreepradha Eswaran, Laura Gebert, Sarah Schraven, Nicole Treichel, Thomas Ritz, Sabine Hamm, Agnes Seeger, Fabian Kiessling, Thomas Clavel, Stephan Dreschers, Norbert Wagner & Angela Schippers |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1943026246 | ||
| 003 | DE-627 | ||
| 005 | 20260119095802.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251201s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41598-025-11555-0 |2 doi | |
| 035 | |a (DE-627)1943026246 | ||
| 035 | |a (DE-599)KXP1943026246 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Eswaran, Sreepradha |e VerfasserIn |0 (DE-588)1243206586 |0 (DE-627)1773861956 |4 aut | |
| 245 | 1 | 0 | |a Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed mice |c Sreepradha Eswaran, Laura Gebert, Sarah Schraven, Nicole Treichel, Thomas Ritz, Sabine Hamm, Agnes Seeger, Fabian Kiessling, Thomas Clavel, Stephan Dreschers, Norbert Wagner & Angela Schippers |
| 264 | 1 | |c 17 July 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.12.2025 | ||
| 520 | |a Metabolic dysfunction associated steatotic liver disease (MASLD) presents a growing global health problem. Disease progression is promoted not only by hepatic leukocyte accumulation but also by inflammatory signals from adipose tissue and an altered gut microbiome. To determine the contribution of intercellular adhesion molecule-1 (ICAM-1) to MASLD pathogenesis, male mice with an ICAM-1 mutation (Icam1tmBay) and wild type (WT) mice were compared in 12 and 24-week feeding experiments with a Western-style diet (WD) containing 40 kcal% fat, 20 kcal% fructose, and 2% cholesterol. WD-induced MASLD was accompanied by increased ICAM-1 expression in liver, epididymal white adipose tissue (EWAT), and intestine in WT mice. WD-fed Icam1tmBay mice exhibited increased circulating neutrophils, higher frequencies of inflammatory leukocytes in EWAT, and a worsened glucose tolerance when compared to WT mice. In contrast, the mutation resulted in reduced WD-induced liver disease activity and less accumulation of intrahepatic leukocytes. WD-feeding caused substantial changes in fecal microbiota with decreased microbial diversity that differed between the mouse strains. In conclusion, ICAM-1 positively regulates adipose tissue homeostasis and protects from insulin resistance but promotes liver damage in diet-induced obesity. This points to organ-specific roles for ICAM-1 and the potential of liver-specific targeting of ICAM-1 for treatment of MASLD. | ||
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Non-alcoholic fatty liver disease | |
| 650 | 4 | |a Non-alcoholic steatohepatitis | |
| 700 | 1 | |a Gebert, Laura |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schraven, Sarah |e VerfasserIn |4 aut | |
| 700 | 1 | |a Treichel, Nicole |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ritz, Thomas |e VerfasserIn |0 (DE-588)1239229739 |0 (DE-627)1767292236 |4 aut | |
| 700 | 1 | |a Hamm, Sabine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Seeger, Agnes |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kiessling, Fabian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Clavel, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dreschers, Stephan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wagner, Norbert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schippers, Angela |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scientific reports |d [London] : Springer Nature, 2011 |g 15(2025), Artikel-ID 25884, Seite 1-14 |h Online-Ressource |w (DE-627)663366712 |w (DE-600)2615211-3 |w (DE-576)346641179 |x 2045-2322 |7 nnas |a Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed mice |
| 773 | 1 | 8 | |g volume:15 |g year:2025 |g elocationid:25884 |g pages:1-14 |g extent:14 |a Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed mice |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41598-025-11555-0 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41598-025-11555-0 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20251201 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1239229739 |a Ritz, Thomas |m 1239229739:Ritz, Thomas |d 50000 |e 50000PR1239229739 |k 0/50000/ |p 5 | ||
| 999 | |a KXP-PPN1943026246 |e 481823463X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 01.12.2025"],"recId":"1943026246","type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed mice","title":"Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed mice"}],"person":[{"family":"Eswaran","display":"Eswaran, Sreepradha","given":"Sreepradha","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Gebert","given":"Laura","role":"aut","roleDisplay":"VerfasserIn","display":"Gebert, Laura"},{"family":"Schraven","role":"aut","roleDisplay":"VerfasserIn","given":"Sarah","display":"Schraven, Sarah"},{"given":"Nicole","roleDisplay":"VerfasserIn","role":"aut","display":"Treichel, Nicole","family":"Treichel"},{"family":"Ritz","role":"aut","roleDisplay":"VerfasserIn","given":"Thomas","display":"Ritz, Thomas"},{"family":"Hamm","role":"aut","roleDisplay":"VerfasserIn","given":"Sabine","display":"Hamm, Sabine"},{"display":"Seeger, Agnes","given":"Agnes","roleDisplay":"VerfasserIn","role":"aut","family":"Seeger"},{"display":"Kiessling, Fabian","roleDisplay":"VerfasserIn","role":"aut","given":"Fabian","family":"Kiessling"},{"family":"Clavel","given":"Thomas","role":"aut","roleDisplay":"VerfasserIn","display":"Clavel, Thomas"},{"family":"Dreschers","display":"Dreschers, Stephan","given":"Stephan","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Wagner","display":"Wagner, Norbert","given":"Norbert","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Schippers","roleDisplay":"VerfasserIn","role":"aut","given":"Angela","display":"Schippers, Angela"}],"language":["eng"],"id":{"eki":["1943026246"],"doi":["10.1038/s41598-025-11555-0"]},"name":{"displayForm":["Sreepradha Eswaran, Laura Gebert, Sarah Schraven, Nicole Treichel, Thomas Ritz, Sabine Hamm, Agnes Seeger, Fabian Kiessling, Thomas Clavel, Stephan Dreschers, Norbert Wagner & Angela Schippers"]},"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"17 July 2025"}],"physDesc":[{"noteIll":"Illustrationen","extent":"14 S."}],"relHost":[{"disp":"Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed miceScientific reports","language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"[London] ; London","dateIssuedKey":"2011","publisher":"Springer Nature ; Nature Publishing Group","dateIssuedDisp":"2011-"}],"title":[{"title_sort":"Scientific reports","title":"Scientific reports"}],"id":{"issn":["2045-2322"],"zdb":["2615211-3"],"eki":["663366712"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1, article number 1 (2011)-"],"note":["Gesehen am 12.07.24"],"recId":"663366712","part":{"pages":"1-14","year":"2025","extent":"14","text":"15(2025), Artikel-ID 25884, Seite 1-14","volume":"15"}}]} | ||
| SRT | |a ESWARANSREINTERCELLU1720 | ||