Cover Image

Genetic risk-dependent brain markers of resilience to childhood Trauma

Resilience to developing emotional disorders is critical for adolescent mental health, especially following childhood trauma. Yet, brain markers of resilience remain poorly understood. By analyzing brain responses to angry faces in a large-scale longitudinal adolescent cohort (IMAGEN), we identified...

Full description

Saved in:
Bibliographic Details
Main Authors: Lu, Han (Author) , Rolls, Edmund T. (Author) , Liu, Hanjia (Author) , Stein, Dan J. (Author) , Sahakian, Barbara J. (Author) , Elliott, Rebecca (Author) , Jia, Tianye (Author) , Xie, Chao (Author) , Xiang, Shitong (Author) , Wang, Nan (Author) , Banaschewski, Tobias (Author) , Bokde, Arun L. W. (Author) , Desrivières, Sylvane (Author) , Flor, Herta (Author) , Grigis, Antoine (Author) , Garavan, Hugh (Author) , Heinz, Andreas (Author) , Brühl, Rüdiger (Author) , Martinot, Jean-Luc (Author) , Martinot, Marie-Laure Paillère (Author) , Artiges, Eric (Author) , Nees, Frauke (Author) , Orfanos, Dimitri Papadopoulos (Author) , Lemaitre, Herve (Author) , Poustka, Luise (Author) , Hohmann, Sarah (Author) , Holz, Nathalie E. (Author) , Fröhner, Juliane H. (Author) , Smolka, Michael N. (Author) , Vaidya, Nilakshi (Author) , Walter, Henrik (Author) , Whelan, Robert (Author) , Schumann, Gunter (Author) , Feng, Jianfeng (Author) , Luo, Qiang (Author)
Format: Article (Journal)
Language:English
Published: 05 July 2025
In: Nature Communications
Year: 2025, Volume: 16, Pages: 1-15
ISSN:2041-1723
DOI:10.1038/s41467-025-61471-0
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-61471-0
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-61471-0
Get full text
Author Notes:Han Lu, Edmund T. Rolls, Hanjia Liu, Dan J. Stein, Barbara J. Sahakian, Rebecca Elliott, Tianye Jia, Chao Xie, Shitong Xiang, Nan Wang, Tobias Banaschewski, Arun L.W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Luise Poustka, Sarah Hohmann, Nathalie Holz, Juliane H. Fröhner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Jianfeng Feng, Qiang Luo & IMAGEN Consortium
Description
Summary:Resilience to developing emotional disorders is critical for adolescent mental health, especially following childhood trauma. Yet, brain markers of resilience remain poorly understood. By analyzing brain responses to angry faces in a large-scale longitudinal adolescent cohort (IMAGEN), we identified two functional networks located in the orbitofrontal and occipital regions. In girls with high genetic risks for depression, higher orbitofrontal-related network activation was associated with a reduced impact of childhood trauma on emotional symptoms at age 19, whereas in those with low genetic risks, lower occipital-related network activation had a similar association. These findings reveal genetic risk-dependent brain markers of resilience (GRBMR). Longitudinally, the orbitofrontal-related GRBMR predicted subsequent emotional disorders in late adolescence, which were generalizable to an independent prospective cohort (ABCD). These findings demonstrate that high polygenic depression risk relates to activations in the orbitofrontal network and to resilience, with implications for biomarkers and treatment.
Item Description:Gesehen am 02.12.2025
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-025-61471-0

Similar Items