Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking
▪ Abstract Eukaryotic cells evolved when their genetic information was packed into the cell nucleus. DNA replication and RNA biogenesis occur inside the nucleus while protein synthesis takes place in the cytoplasm. Bi-directional trafficking between these two compartments is mediated by a single sup...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
December 1997
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| In: |
Annual review of genetics
Year: 1997, Volume: 31, Pages: 277-313 |
| ISSN: | 1545-2948 |
| DOI: | 10.1146/annurev.genet.31.1.277 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1146/annurev.genet.31.1.277 Verlag, lizenzpflichtig, Volltext: https://www.annualreviews.org/content/journals/10.1146/annurev.genet.31.1.277 
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| Author Notes: | Emmanuelle Fabre and Ed Hurt |
| Summary: | ▪ Abstract Eukaryotic cells evolved when their genetic information was packed into the cell nucleus. DNA replication and RNA biogenesis occur inside the nucleus while protein synthesis takes place in the cytoplasm. Bi-directional trafficking between these two compartments is mediated by a single supramolecular assembly, the nuclear pore complex. Nucleocytoplasmic transport is signal mediated, energy dependent, and requires, besides nuclear pore proteins (nucleoporins), a number of soluble transport factors. We review here our current knowledge on the role of nucleoporins, and on the mechanism of nucleocytoplasmic transport, with emphasis on the yeast Saccharomyces cerevisiae. |
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| Item Description: | Gesehen am 02.12.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1545-2948 |
| DOI: | 10.1146/annurev.genet.31.1.277 |